Literature DB >> 35399448

Importance of Early Next-Generation Sequencing in Microsatellite Unstable Colon Cancer With a High Tumor Mutation Burden.

Sethi Ashish1, Moses Raj2.   

Abstract

Colon cancer is one of the leading causes of cancer-related deaths. Microsatellite instability (MSI) or deficient mismatch repair proteins with a high tumor mutation burden (TMB) colon cancer are less responsive to chemotherapy. Targeted therapies based on early next-generation sequencing (NGS) in metastatic colon cancer can help significantly in overall prognosis. Here, we report a case of colon cancer that illustrated significant TMB and MSI and responded poorly to treatment due to delay in NGS testing.
Copyright © 2022, Ashish et al.

Entities:  

Keywords:  brca gene mutation - predominantly brca2; colon cancer; keynote 177; metastatic colorectal cancer; microsatellite instability (msi); msi high; next-generation sequencing (ngs); olympia trial; polo trial; tumor mutation burden

Year:  2022        PMID： 35399448      PMCID： PMC8983027          DOI： 10.7759/cureus.22894

Source DB:  PubMed          Journal:  Cureus        ISSN： 2168-8184


  9 in total

1.  Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade.

Authors:  Dung T Le; Jennifer N Durham; Kellie N Smith; Hao Wang; Bjarne R Bartlett; Laveet K Aulakh; Steve Lu; Holly Kemberling; Cara Wilt; Brandon S Luber; Fay Wong; Nilofer S Azad; Agnieszka A Rucki; Dan Laheru; Ross Donehower; Atif Zaheer; George A Fisher; Todd S Crocenzi; James J Lee; Tim F Greten; Austin G Duffy; Kristen K Ciombor; Aleksandra D Eyring; Bao H Lam; Andrew Joe; S Peter Kang; Matthias Holdhoff; Ludmila Danilova; Leslie Cope; Christian Meyer; Shibin Zhou; Richard M Goldberg; Deborah K Armstrong; Katherine M Bever; Amanda N Fader; Janis Taube; Franck Housseau; David Spetzler; Nianqing Xiao; Drew M Pardoll; Nickolas Papadopoulos; Kenneth W Kinzler; James R Eshleman; Bert Vogelstein; Robert A Anders; Luis A Diaz
Journal:  Science       Date:  2017-06-08       Impact factor: 47.728

Review 2.  DNA mismatch repair in cancer.

Authors:  Marina Baretti; Dung T Le
Journal:  Pharmacol Ther       Date:  2018-04-15       Impact factor: 12.310

3.  Maintenance Olaparib for Germline BRCA-Mutated Metastatic Pancreatic Cancer.

Authors:  Talia Golan; Pascal Hammel; Michele Reni; Eric Van Cutsem; Teresa Macarulla; Michael J Hall; Joon-Oh Park; Daniel Hochhauser; Dirk Arnold; Do-Youn Oh; Anke Reinacher-Schick; Giampaolo Tortora; Hana Algül; Eileen M O'Reilly; David McGuinness; Karen Y Cui; Katia Schlienger; Gershon Y Locker; Hedy L Kindler
Journal:  N Engl J Med       Date:  2019-06-02       Impact factor: 91.245

Review 4.  The EMA assessment of pembrolizumab as monotherapy for the first-line treatment of adult patients with metastatic microsatellite instability-high or mismatch repair deficient colorectal cancer.

Authors:  A Trullas; J Delgado; A Genazzani; J Mueller-Berghaus; C Migali; S Müller-Egert; H Zander; H Enzmann; F Pignatti
Journal:  ESMO Open       Date:  2021-04-30

5.  Adjuvant Olaparib for Patients with BRCA1- or BRCA2-Mutated Breast Cancer.

Authors:  Andrew N J Tutt; Judy E Garber; Bella Kaufman; Giuseppe Viale; Debora Fumagalli; Priya Rastogi; Richard D Gelber; Evandro de Azambuja; Anitra Fielding; Judith Balmaña; Susan M Domchek; Karen A Gelmon; Simon J Hollingsworth; Larissa A Korde; Barbro Linderholm; Hanna Bandos; Elżbieta Senkus; Jennifer M Suga; Zhimin Shao; Andrew W Pippas; Zbigniew Nowecki; Tomasz Huzarski; Patricia A Ganz; Peter C Lucas; Nigel Baker; Sibylle Loibl; Robin McConnell; Martine Piccart; Rita Schmutzler; Guenther G Steger; Joseph P Costantino; Amal Arahmani; Norman Wolmark; Eleanor McFadden; Vassiliki Karantza; Sunil R Lakhani; Greg Yothers; Christine Campbell; Charles E Geyer
Journal:  N Engl J Med       Date:  2021-06-03       Impact factor: 176.079

6.  Tumor Mutational Burden as a Predictive Biomarker in Solid Tumors.

Authors:  Dan Sha; Zhaohui Jin; Jan Budczies; Klaus Kluck; Albrecht Stenzinger; Frank A Sinicrope
Journal:  Cancer Discov       Date:  2020-11-02       Impact factor: 38.272

7.  A next-generation sequencing-based strategy combining microsatellite instability and tumor mutation burden for comprehensive molecular diagnosis of advanced colorectal cancer.

Authors:  Jian Xiao; Wenyun Li; Yan Huang; Mengli Huang; Shanshan Li; Xiaohui Zhai; Jing Zhao; Chan Gao; Wenzhuan Xie; Hao Qin; Shangli Cai; Yuezong Bai; Ping Lan; Yifeng Zou
Journal:  BMC Cancer       Date:  2021-03-16       Impact factor: 4.430

8.  Extramedullary Hematopoiesis in Mismatch Repair Deficient Colon Cancer Patient on Adjuvant Chemotherapy.

Authors:  Edward K De Leo; Chintan P Shah; Joseph R Grajo; Xiuli Liu; Hiral Parekh
Journal:  Cureus       Date:  2021-01-25

Review 9.  Immune Checkpoint Inhibition in Metastatic Colorectal Cancer Harboring Microsatellite Instability or Mismatch Repair Deficiency.

Authors:  Romain Cohen; Raphaël Colle; Thomas Pudlarz; Maximilien Heran; Alex Duval; Magali Svrcek; Thierry André
Journal:  Cancers (Basel)       Date:  2021-03-08       Impact factor: 6.639
  9 in total

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