Background/Aim: We assessed the prognosis of patients with refractory or relapsed multiple myeloma (RRMM) by focusing on the change in absolute lymphocyte counts (ALCs) after lenalidomide and dexamethasone (Ld) initiation. Patients and Methods: In total, 72 patients with RRMM were treated with Ld. ALCs were evaluated before treatment and at 1, 2, and 3 months after Ld initiation. The median ALCs in the entire cohort before and at 1, 2, 3 months after Ld initiation were 1,131, 1,059, 1,222, and 1,162/μl, respectively. Results: ALCs before Ld initiation did not affect time to next treatment (TNT) or overall survival (OS). However, the patients with ALCs equal to or greater than the median at 3 months showed relatively better TNT than those with lower lymphocyte counts, with a significant difference. OS was also significantly longer in patients with higher ALCs. Conclusion: Immunomodulation by lenalidomide may improve prognosis in patients with RRMM. Copyright 2021, International Institute of Anticancer Research.
Background/Aim: We assessed the prognosis of patients with refractory or relapsed multiple myeloma (RRMM) by focusing on the change in absolute lymphocyte counts (ALCs) after lenalidomide and dexamethasone (Ld) initiation. Patients and Methods: In total, 72 patients with RRMM were treated with Ld. ALCs were evaluated before treatment and at 1, 2, and 3 months after Ld initiation. The median ALCs in the entire cohort before and at 1, 2, 3 months after Ld initiation were 1,131, 1,059, 1,222, and 1,162/μl, respectively. Results: ALCs before Ld initiation did not affect time to next treatment (TNT) or overall survival (OS). However, the patients with ALCs equal to or greater than the median at 3 months showed relatively better TNT than those with lower lymphocyte counts, with a significant difference. OS was also significantly longer in patients with higher ALCs. Conclusion: Immunomodulation by lenalidomide may improve prognosis in patients with RRMM. Copyright 2021, International Institute of Anticancer Research.
Authors: Meletios A Dimopoulos; Albert Oriol; Hareth Nahi; Jesus San-Miguel; Nizar J Bahlis; Saad Z Usmani; Neil Rabin; Robert Z Orlowski; Mieczyslaw Komarnicki; Kenshi Suzuki; Torben Plesner; Sung-Soo Yoon; Dina Ben Yehuda; Paul G Richardson; Hartmut Goldschmidt; Donna Reece; Steen Lisby; Nushmia Z Khokhar; Lisa O'Rourke; Christopher Chiu; Xiang Qin; Mary Guckert; Tahamtan Ahmadi; Philippe Moreau Journal: N Engl J Med Date: 2016-10-06 Impact factor: 91.245
Authors: Guillermo De Angulo; Carrie Yuen; Shana L Palla; Peter M Anderson; Patrick A Zweidler-McKay Journal: Cancer Date: 2008-01-15 Impact factor: 6.860
Authors: M Ilander; U Olsson-Strömberg; H Schlums; J Guilhot; O Brück; H Lähteenmäki; T Kasanen; P Koskenvesa; S Söderlund; M Höglund; B Markevärn; A Själander; K Lotfi; A Dreimane; A Lübking; E Holm; M Björeman; S Lehmann; L Stenke; L Ohm; T Gedde-Dahl; W Majeed; H Ehrencrona; S Koskela; S Saussele; F-X Mahon; K Porkka; H Hjorth-Hansen; Y T Bryceson; J Richter; S Mustjoki Journal: Leukemia Date: 2016-11-28 Impact factor: 11.528