Literature DB >> 23968916

Low NK cell counts in peripheral blood are associated with inferior overall survival in patients with follicular lymphoma.

Danielle Shafer1, Mitchell R Smith, Hossein Borghaei, Michael M Millenson, Tianyu Li, Samuel Litwin, Rachna Anad, Tahseen Al-Saleem.   

Abstract

Host immune responses influence follicular lymphoma (FL) outcomes. To test our hypothesis that immune cells in blood reflect that response, we assessed by peripheral blood flow cytometry in 75 untreated FL patients the absolute counts of: lymphocytes (ALC), CD4(+)T (ACD4C), CD8(+)T (ACD8C) and natural killer (ANKC) cells. Low ANKC was the only parameter associated with inferior overall survival by univariate analysis (p=0.02), and trended to significance in multivariable analysis with ACD4C (p=0.08). Five (24%) patients with low initial ANKC died, while one (2%) with normal/high ANKC has died. In conclusion, evaluation of blood ANKC may be a useful indicator of outcome in previously untreated FL patients.
Copyright © 2013 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Follicular lymphoma; Immunology; Lymphocyte subsets; NK cells; Prognosis

Mesh：

Year:  2013        PMID： 23968916      PMCID： PMC3976217          DOI： 10.1016/j.leukres.2013.07.038

Source DB:  PubMed          Journal:  Leuk Res        ISSN： 0145-2126            Impact factor:   3.156


  21 in total

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Authors:  L F Porrata; K Ristow; T E Witzig; N Tuinistra; T M Habermann; D J Inwards; S M Ansell; I N Micallef; P B Johnston; S N Markovic
Journal:  Leukemia       Date:  2007-06-21       Impact factor: 11.528

3.  Absolute lymphocyte count predicts overall survival in follicular lymphomas.

Authors:  Mustaqeem Siddiqui; Kay Ristow; Svetomir N Markovic; Thomas E Witzig; Thomas M Habermann; Joseph P Colgan; David J Inwards; William L White; Stephen M Ansell; Ivana N Micallef; Patrick B Johnston; Timothy G Call; Luis F Porrata
Journal:  Br J Haematol       Date:  2006-08-01       Impact factor: 6.998

4.  Analysis of multiple biomarkers shows that lymphoma-associated macrophage (LAM) content is an independent predictor of survival in follicular lymphoma (FL).

Authors:  Pedro Farinha; Hamid Masoudi; Brian F Skinnider; Karey Shumansky; John J Spinelli; Karamjit Gill; Richard Klasa; Nicolas Voss; Joseph M Connors; Randy D Gascoyne
Journal:  Blood       Date:  2005-06-02       Impact factor: 22.113

5.  Follicular lymphomas can be induced to present alloantigen efficiently: a conceptual model to improve their tumor immunogenicity.

Authors:  J L Schultze; A A Cardoso; G J Freeman; M J Seamon; J Daley; G S Pinkus; J G Gribben; L M Nadler
Journal:  Proc Natl Acad Sci U S A       Date:  1995-08-29       Impact factor: 11.205

6.  Prognostic importance of T and NK-cells in a consecutive series of newly diagnosed patients with chronic lymphocytic leukaemia.

Authors:  Shanique Palmer; Curtis A Hanson; Clive S Zent; Luis F Porrata; Betsy Laplant; Susan M Geyer; Svetomir N Markovic; Timothy G Call; Deborah A Bowen; Diane F Jelinek; Neil E Kay; Tait D Shanafelt
Journal:  Br J Haematol       Date:  2008-04-01       Impact factor: 6.998

7.  Follicular lymphoma cells induce T-cell immunologic synapse dysfunction that can be repaired with lenalidomide: implications for the tumor microenvironment and immunotherapy.

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8.  lenalidomide enhances natural killer cell and monocyte-mediated antibody-dependent cellular cytotoxicity of rituximab-treated CD20+ tumor cells.

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Journal:  Blood       Date:  2004-05-04       Impact factor: 22.113

10.  Local and systemic induction of CD4+CD25+ regulatory T-cell population by non-Hodgkin lymphoma.

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Journal:  Blood       Date:  2008-02-27       Impact factor: 22.113
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  15 in total

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Authors:  Shogo Kumagai; Masaharu Tashima; Jun Fujikawa; Makoto Iwasaki; Yoshihiro Iwamoto; Yuki Sueki; Akiko Fukunaga; Soshi Yanagita; Momoko Nishikori; Akifumi Takaori-Kondo; Nobuyoshi Arima
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2.  Low absolute CD4+ T cell counts in peripheral blood are associated with inferior survival in follicular lymphoma.

Authors:  Lu He; Jin-Hua Liang; Jia-Zhu Wu; Yue Li; Shu-Chao Qin; Yi Miao; Yu-Jie Wu; Yan Wang; Li Wang; Lei Fan; Jian-Yong Li; Wei Xu
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3.  Cell-based immunotherapy in stage IIIA inflammatory breast cancer with declining innate immunity following successive chemotherapies: A case report.

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4.  Absolute Lymphocyte Counts After Lenalidomide Initiation may Predict the Prognosis of Patients With Relapsed or Refractory Multiple Myeloma.

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Review 5.  Role of the ITAM-Bearing Receptors Expressed by Natural Killer Cells in Cancer.

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6.  Follicular lymphoma: in vitro effects of combining lymphokine-activated killer (LAK) cell-induced cytotoxicity and rituximab- and obinutuzumab-dependent cellular cytotoxicity (ADCC) activity.

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Journal:  Immunol Res       Date:  2016-04       Impact factor: 2.829

7.  Expression of activating receptors on natural killer cells from AIDS-related lymphoma patients.

Authors:  Delphine Mercier-Bataille; Carole Sanchez; Céline Baier; Thérèse Le Treut; Nicolas Mounier; Saadia Mokhtari; Daniel Olive; Karine Baumstarck; Gérard Sébahoun; Caroline Besson; Régis T Costello
Journal:  AIDS Res Ther       Date:  2014-11-24       Impact factor: 2.250

8.  Low Circulating Natural Killer Cell Counts are Associated With Severe Disease in Patients With Common Variable Immunodeficiency.

Authors:  Mikael Ebbo; Laurence Gérard; Sabrina Carpentier; Frédéric Vély; Sophie Cypowyj; Catherine Farnarier; Nicolas Vince; Marion Malphettes; Claire Fieschi; Eric Oksenhendler; Nicolas Schleinitz; Eric Vivier
Journal:  EBioMedicine       Date:  2016-03-02       Impact factor: 8.143

9.  Peripheral blood lymphocyte/monocyte ratio at the time of first relapse predicts outcome for patients with relapsed or primary refractory diffuse large B-cell lymphoma.

Authors:  Yan-Li Li; Kang-Sheng Gu; Yue-Yin Pan; Yang Jiao; Zhi-Min Zhai
Journal:  BMC Cancer       Date:  2014-05-19       Impact factor: 4.430

10.  Low natural killer (NK) cell counts in peripheral blood adversely affect clinical outcome of patients with follicular lymphoma.

Authors:  L He; H-Y Zhu; S-C Qin; Y Li; Y Miao; J-H Liang; Y Xia; Y Wang; Y-J Wu; L Wang; L Fan; J-Y Li; W Xu
Journal:  Blood Cancer J       Date:  2016-08-12       Impact factor: 11.037
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