Alessandra Bisquera1, Christopher Harris2,3, Alan Lunt2,3, Sanja Zivanovic2,3, Neil Marlow4, Sandy Calvert5, Anne Greenough2,3,6, Janet L Peacock1,7. 1. School of Population Health and Environmental Sciences, King's College London, London, UK. 2. Department of Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK. 3. Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London, London, UK. 4. Department of Neonatal Medicine, Elizabeth Garrett Anderson UCL Institute for Women's Health, University College, London, UK. 5. Department of Child Health, St George's Hospital, London, UK. 6. NIHR Biomedical Research Centre based at Guy's and St Thomas', NHS Foundation Trust and King's College London, London, UK. 7. Department of Epidemiology, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA.
Abstract
OBJECTIVE: To examine changes in lung function over time in extremely prematurely born adolescents. WORKING HYPOTHESIS: Changes in lung function during adolescence would vary by ventilation mode immediately after birth. STUDY DESIGN: Longitudinal follow-up study. PATIENT SUBJECT SELECTION: Participants from the United Kingdom Oscillation Study who were randomized at birth to high-frequency oscillation (HFO) or conventional ventilation (CV) were assessed at 11-14 years (n = 319) and at 16-19 years (n = 159). METHODOLOGY: Forced expiratory flow (FEF), forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), and lung volumes including functional residual capacity (FRC) were reported as z-scores. The diffusion capacity of the lungs for carbon monoxide (DLCO) was measured. Lung function trajectories were compared by mode of ventilation using mixed models. Changes in z-scores were scaled to 5-year average follow-up. RESULTS: There were significant changes in the mean FEF75, FEF50, FEF25, FEV1, FVC, and DLCO z-scores within the CV and HFO cohorts, but no significant differences in the changes between the two groups. The mean FRC z-score increased in both groups, with an average change of greater than one z-score. The mean FEV1/FVC z-score increased significantly in the CV group, but not in the HFO group (difference in slopes: p = 0.02). Across the population, deterioration in lung function was associated with male sex, white ethnicity, lower gestational age at birth, postnatal corticosteroids, oxygen dependency at 36 weeks postmenstrual age, and lower birth weight, but not ventilation mode. CONCLUSIONS: There was little evidence that the mode of ventilation affected changes in lung function over time.
OBJECTIVE: To examine changes in lung function over time in extremely prematurely born adolescents. WORKING HYPOTHESIS: Changes in lung function during adolescence would vary by ventilation mode immediately after birth. STUDY DESIGN: Longitudinal follow-up study. PATIENT SUBJECT SELECTION: Participants from the United Kingdom Oscillation Study who were randomized at birth to high-frequency oscillation (HFO) or conventional ventilation (CV) were assessed at 11-14 years (n = 319) and at 16-19 years (n = 159). METHODOLOGY: Forced expiratory flow (FEF), forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), and lung volumes including functional residual capacity (FRC) were reported as z-scores. The diffusion capacity of the lungs for carbon monoxide (DLCO) was measured. Lung function trajectories were compared by mode of ventilation using mixed models. Changes in z-scores were scaled to 5-year average follow-up. RESULTS: There were significant changes in the mean FEF75, FEF50, FEF25, FEV1, FVC, and DLCO z-scores within the CV and HFO cohorts, but no significant differences in the changes between the two groups. The mean FRC z-score increased in both groups, with an average change of greater than one z-score. The mean FEV1/FVC z-score increased significantly in the CV group, but not in the HFO group (difference in slopes: p = 0.02). Across the population, deterioration in lung function was associated with male sex, white ethnicity, lower gestational age at birth, postnatal corticosteroids, oxygen dependency at 36 weeks postmenstrual age, and lower birth weight, but not ventilation mode. CONCLUSIONS: There was little evidence that the mode of ventilation affected changes in lung function over time.
Authors: G Moriette; J Paris-Llado; H Walti; B Escande; J F Magny; G Cambonie; G Thiriez; S Cantagrel; T Lacaze-Masmonteil; L Storme; T Blanc; J M Liet; C André; B Salanave; G Bréart Journal: Pediatrics Date: 2001-02 Impact factor: 7.124
Authors: Ward Hofhuis; Marianne W A Huysman; Els C van der Wiel; Wim P J Holland; Wim C J Hop; Govert Brinkhorst; Johan C de Jongste; Peter J F M Merkus Journal: Am J Respir Crit Care Med Date: 2002-12-15 Impact factor: 21.405
Authors: Alice H Johnson; Janet L Peacock; Anne Greenough; Neil Marlow; Elizabeth S Limb; Louise Marston; Sandra A Calvert Journal: N Engl J Med Date: 2002-08-29 Impact factor: 91.245
Authors: E Marije Bakker; Gerard J J M Borsboom; Els C van der Wiel-Kooij; Daan Caudri; Margaret Rosenfeld; Harm A W M Tiddens Journal: Pediatr Pulmonol Date: 2013-02-08
Authors: Christopher Harris; Siobhan Crichton; Sanja Zivanovic; Alan Lunt; Sandy Calvert; Neil Marlow; Janet L Peacock; Anne Greenough Journal: PLoS One Date: 2018-07-09 Impact factor: 3.240
Authors: Sherry E Courtney; David J Durand; Jeanette M Asselin; Eric C Eichenwald; Ann R Stark Journal: Crit Care Date: 2003-04-14 Impact factor: 9.097
Authors: Charles Opondo; Hiranthi Jayaweera; Jennifer Hollowell; Yangmei Li; Jennifer J Kurinczuk; Maria A Quigley Journal: J Epidemiol Community Health Date: 2020-01-21 Impact factor: 3.710
Authors: Alessandra Bisquera; Christopher Harris; Alan Lunt; Sanja Zivanovic; Neil Marlow; Sandy Calvert; Anne Greenough; Janet L Peacock Journal: Pediatr Pulmonol Date: 2022-04-18