Jessica Lo1, Sanja Zivanovic2,3, Alan Lunt2,3, Mireia Alcazar-Paris2,3, Gwendolyn Andradi2,3, Mark Thomas4, Neil Marlow5, Sandy Calvert6, Janet Peacock7,8, Anne Greenough2,3,8. 1. School of Psychiatry UNSW Medicine, University of New South Wales, Sydney, Australia. 2. MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London, London, United Kingdom. 3. Faculty of Life Sciences and Medicine, Women and Children's Health, School of Life Course Sciences, King's College London, London, United Kingdom. 4. Neonatal Medicine, Chelsea and Westminster Hospital, London, United Kingdom. 5. Neonatal Medicine, Institute for Women's Health, London, United Kingdom. 6. Child Health, St. George's Hospital, London, United Kingdom. 7. Faculty of Life Sciences and Medicine School of Population Health and Environmental Sciences, King's College London, London, United Kingdom. 8. NIHR Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust and King's College London, London, United Kingdom.
Abstract
OBJECTIVES: To assess longitudinally small airway function in children born extremely prematurely and whether there was a correlation between airway function in infancy and at 11-14 years. WORKING HYPOTHESES: There would be tracking of airways obstruction and small airway function would deteriorate during childhood in those born extremely prematurely. STUDY DESIGN: A longitudinal study. PATIENT-SUBJECT SELECTION: Thirty-five children with a mean gestational age of 26 weeks had lung function assessed at 1 year corrected and 11-14 years of age. METHODOLOGY: Lung volumes were measured by helium gas dilution (FRCHe ) and plethysmography (FRCpleth ) and small airway function assessed by calculating the FRCHe :FRCpleth ratio. Airway function was assessed at 1 year corrected by measurement of airway resistance (Raw ) and at 11-14 years by assessment of Raw , forced expiratory flow from 75% of vital capacity (FEF75 ), and forced expiratory volume at one second (FEV1 ). RESULTS: At the first assessment, the children had a mean (SD) FRCHe :FRCpleth of 0.90 (0.13) and at the second, 0.83 (0.12) (P = 0.035). There was a significant 0.54% decrease (95%CI: -1.02%, -0.06%) in FRCHe :FRCpleth for increased age per year after adjusting for birth weight, gestational age, sex, and bronchopulmonary dysplasia (P = 0.027). There were significant correlations between Raw at the first assessment and Raw (P = 0.012), FEF75 (P = 0.034), and FEV1 (P = 0.04) at 11-14 years. CONCLUSIONS: These results demonstrate in those born extremely prematurely there is tracking of airway function during childhood.
OBJECTIVES: To assess longitudinally small airway function in children born extremely prematurely and whether there was a correlation between airway function in infancy and at 11-14 years. WORKING HYPOTHESES: There would be tracking of airways obstruction and small airway function would deteriorate during childhood in those born extremely prematurely. STUDY DESIGN: A longitudinal study. PATIENT-SUBJECT SELECTION: Thirty-five children with a mean gestational age of 26 weeks had lung function assessed at 1 year corrected and 11-14 years of age. METHODOLOGY: Lung volumes were measured by helium gas dilution (FRCHe ) and plethysmography (FRCpleth ) and small airway function assessed by calculating the FRCHe :FRCpleth ratio. Airway function was assessed at 1 year corrected by measurement of airway resistance (Raw ) and at 11-14 years by assessment of Raw , forced expiratory flow from 75% of vital capacity (FEF75 ), and forced expiratory volume at one second (FEV1 ). RESULTS: At the first assessment, the children had a mean (SD) FRCHe :FRCpleth of 0.90 (0.13) and at the second, 0.83 (0.12) (P = 0.035). There was a significant 0.54% decrease (95%CI: -1.02%, -0.06%) in FRCHe :FRCpleth for increased age per year after adjusting for birth weight, gestational age, sex, and bronchopulmonary dysplasia (P = 0.027). There were significant correlations between Raw at the first assessment and Raw (P = 0.012), FEF75 (P = 0.034), and FEV1 (P = 0.04) at 11-14 years. CONCLUSIONS: These results demonstrate in those born extremely prematurely there is tracking of airway function during childhood.
Authors: Alessandra Bisquera; Christopher Harris; Alan Lunt; Sanja Zivanovic; Neil Marlow; Sandy Calvert; Anne Greenough; Janet L Peacock Journal: Pediatr Pulmonol Date: 2022-04-18
Authors: Nara S Higano; David R Spielberg; Robert J Fleck; Andrew H Schapiro; Laura L Walkup; Andrew D Hahn; Jean A Tkach; Paul S Kingma; Stephanie L Merhar; Sean B Fain; Jason C Woods Journal: Am J Respir Crit Care Med Date: 2018-11-15 Impact factor: 30.528
Authors: Anne Louise de Barros Damgaard; Rasmus Gregersen; Theis Lange; Frederik Buchvald; Bo Mølholm Hansen; Gorm Greisen Journal: PLoS One Date: 2018-07-05 Impact factor: 3.240
Authors: Christopher Harris; Siobhan Crichton; Sanja Zivanovic; Alan Lunt; Sandy Calvert; Neil Marlow; Janet L Peacock; Anne Greenough Journal: PLoS One Date: 2018-07-09 Impact factor: 3.240