Literature DB >> 3537956

Transcriptional arrest within the first exon is a fast control mechanism in c-myc gene expression.

D Eick, G W Bornkamm.   

Abstract

DMSO (dimethylsulfoxide), a potent inducer of granulocytic differentiation in HL60 cells, causes a rapid decrease of cytoplasmic steady state c-myc RNA. This decrease is regulated mainly at the level of transcript elongation. Elongation is blocked within the untranslated c-myc leader. Twelve hours after transcriptional shut off of c-myc, DNAase I hypersensitive site II was still detectable, indicating that closing of this site upstream of the gene does not correlate with reduction in the steady state level of c-myc RNA.

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Year:  1986        PMID： 3537956      PMCID： PMC311862          DOI： 10.1093/nar/14.21.8331

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  59 in total

1.  Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I.

Authors:  P W Rigby; M Dieckmann; C Rhodes; P Berg
Journal:  J Mol Biol       Date:  1977-06-15       Impact factor: 5.469

2.  Multiple arrangements of viral DNA and an activated host oncogene in bursal lymphomas.

Authors:  G S Payne; J M Bishop; H E Varmus
Journal:  Nature       Date:  1982-01-21       Impact factor: 49.962

3.  Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis.

Authors:  W S Hayward; B G Neel; S M Astrin
Journal:  Nature       Date:  1981-04-09       Impact factor: 49.962

4.  Commitment to differentiation in Friend cells and initiation of globin mRNA synthesis occurs during the G1 phase of the cell cycle.

Authors:  I B Pragnell; D J Arndt-Jovin; T M Jovin; B Fagg; W Ostertag
Journal:  Exp Cell Res       Date:  1980-02       Impact factor: 3.905

Review 5.  Attenuation in the control of expression of bacterial operons.

Authors:  C Yanofsky
Journal:  Nature       Date:  1981-02-26       Impact factor: 49.962

6.  Proflavine sensitivity of RNA processing in isolated nuclei.

Authors:  A Yannarell; M Niemann; D E Schumm; T E Webb
Journal:  Nucleic Acids Res       Date:  1977-03       Impact factor: 16.971

7.  Evidence for the role of double-helical structures in the maturation of simian virus-40 messenger RNA.

Authors:  N H Chiu; W B Bruszewski; N P Salzman
Journal:  Nucleic Acids Res       Date:  1980-01-11       Impact factor: 16.971

8.  Effect of lucanthone (miracil D) on transcription of ribosomal RNA genes from Tetrahymena in vivo and in vitro.

Authors:  O Westergaard; E Gocke; O F Nielsen; J C Leer
Journal:  Nucleic Acids Res       Date:  1979-06-11       Impact factor: 16.971

9.  Analysis of avian leukosis virus DNA and RNA in bursal tumours: viral gene expression is not required for maintenance of the tumor state.

Authors:  G S Payne; S A Courtneidge; L B Crittenden; A M Fadly; J M Bishop; H E Varmus
Journal:  Cell       Date:  1981-02       Impact factor: 41.582

10.  Terminal differentiation of human promyelocytic leukemia cells induced by dimethyl sulfoxide and other polar compounds.

Authors:  S J Collins; F W Ruscetti; R E Gallagher; R C Gallo
Journal:  Proc Natl Acad Sci U S A       Date:  1978-05       Impact factor: 11.205
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  88 in total

1.  A short, highly repetitive element in intron -1 of the human c-Ha-ras gene acts as a block to transcriptional readthrough by a viral promoter.

Authors:  N F Lowndes; P Bushel; L Mendelsohn; J Wu; M Y Yen; M Allan
Journal:  Mol Cell Biol       Date:  1990-09       Impact factor: 4.272

2.  A cis-acting element in the promoter region of the murine c-myc gene is necessary for transcriptional block.

Authors:  H Miller; C Asselin; D Dufort; J Q Yang; K Gupta; K B Marcu; A Nepveu
Journal:  Mol Cell Biol       Date:  1989-12       Impact factor: 4.272

3.  Analysis of premature termination in c-myc during transcription by RNA polymerase II in a HeLa nuclear extract.

Authors:  L London; R G Keene; R Landick
Journal:  Mol Cell Biol       Date:  1991-09       Impact factor: 4.272

4.  In vivo dynamics of RNA polymerase II transcription.

Authors:  Xavier Darzacq; Yaron Shav-Tal; Valeria de Turris; Yehuda Brody; Shailesh M Shenoy; Robert D Phair; Robert H Singer
Journal:  Nat Struct Mol Biol       Date:  2007-08-05       Impact factor: 15.369

5.  Tyrosine kinase oncogenes abrogate interleukin-3 dependence of murine myeloid cells through signaling pathways involving c-myc: conditional regulation of c-myc transcription by temperature-sensitive v-abl.

Authors:  J L Cleveland; M Dean; N Rosenberg; J Y Wang; U R Rapp
Journal:  Mol Cell Biol       Date:  1989-12       Impact factor: 4.272

6.  Identification of two enhancer elements downstream of the human c-myc gene.

Authors:  J Mautner; S Joos; T Werner; D Eick; G W Bornkamm; A Polack
Journal:  Nucleic Acids Res       Date:  1995-01-11       Impact factor: 16.971

7.  Regulation of 4F2 heavy-chain gene expression during normal human T-cell activation can be mediated by multiple distinct molecular mechanisms.

Authors:  T Lindsten; C H June; C B Thompson; J M Leiden
Journal:  Mol Cell Biol       Date:  1988-09       Impact factor: 4.272

8.  Loss of Marek's disease virus tumorigenicity is associated with truncation of RNAs transcribed within BamHI-H.

Authors:  G Bradley; G Lancz; A Tanaka; M Nonoyama
Journal:  J Virol       Date:  1989-10       Impact factor: 5.103

9.  Transcriptional activation of cellular oncogenes fos, jun, and myc by human cytomegalovirus.

Authors:  I Boldogh; S AbuBakar; C Z Deng; T Albrecht
Journal:  J Virol       Date:  1991-03       Impact factor: 5.103

10.  A single nucleotide change in the c-myc internal ribosome entry segment leads to enhanced binding of a group of protein factors.

Authors:  F E Paulin; S A Chappell; A E Willis
Journal:  Nucleic Acids Res       Date:  1998-07-01       Impact factor: 16.971
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