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Literature DB >> 35352256

Estimation of the Regenerative Potential of para-Tyrosol in the Model of Testicular Insufficiency Caused by Damage to Spermatogonial Stem Cells.

T G Borovskaya¹, V A Grigor'eva², Yu A Shchemerova², S I Kamalova², A V Vychuzhanina², N A Krivova³, O B Zaeva³, V E Goldberg⁴, A M Dygai².

Abstract

The regenerative properties of p-tyrosol were investigated in a model of testicular insufficiency caused by a toxic effect on spermatogonial stem cells (single administration of paclitaxel in the maximum tolerable dose). Against the background of p-tyrosol administration, we observed an increase in the number of normal spermatogonia and Sertoli cells, stimulation of spermatogenesis, and renewal of the spermatogenic tissue. The treatment with p-tyrosol also led to a decrease in DNA damage in cells of the testicular tissue. These changes were accompanied by a decrease in the level of free radicals, an increase in antioxidant protection, and normalization of the redox potential.

Entities: Chemical

Keywords: paclitaxel; para-tyrosol; rats; spermatogonia; testes

Mesh：

Substances：

Year: 2022 PMID： 35352256 DOI： 10.1007/s10517-022-05452-z

Source DB: PubMed Journal: Bull Exp Biol Med ISSN： 0007-4888 Impact factor: 0.804

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References

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Estimation of the Regenerative Potential of para-Tyrosol in the Model of Testicular Insufficiency Caused by Damage to Spermatogonial Stem Cells.

1. Responses of Spermatogenous Tissue and Mechanisms of Their Development Upon Cytostatic Exposure.

2. Improved chemiluminescence assay for measuring antioxidant capacity of seminal plasma.

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