Literature DB >> 3533950

DNA adducts by N-nitroso compounds.

M Wiessler.   

Abstract

Some unsolved problems in DNA alkylation by N-nitroso compounds are discussed in this overview. Does O6 alkylation of guanine represent the initiating event exclusively or are O4 alkylation of thymidine and phosphate triester formation also involved in the initiating process? Does the formation of rearranged DNA alkylation products by longer chained alkylnitroso compounds have any significance for the carcinogenic effects of these compounds? The concept of hard and soft acids and bases (HSAB principle) as a qualitative model can predict the changes in the DNA alkylation pattern by branched carbenium ions.

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Year:  1986        PMID： 3533950     DOI： 10.1007/bf00404386

Source DB:  PubMed          Journal:  J Cancer Res Clin Oncol        ISSN： 0171-5216            Impact factor:   4.553


  23 in total

1.  Acids and bases.

Authors:  R G Pearson
Journal:  Science       Date:  1966-01-14       Impact factor: 47.728

2.  Sites and thermodynamic quantities associated with proton and metal ion interaction with ribonucleic acid, deoxyribonucleic acid, and their constituent bases, nucleosides, and nucleotides.

Authors:  R M Izatt; J J Christensen; J H Rytting
Journal:  Chem Rev       Date:  1971-10       Impact factor: 60.622

3.  Methylation of the O6 position of guanine in DNA is the most likely initiating event in carcinogenesis by methylating agents.

Authors:  A E Pegg
Journal:  Cancer Invest       Date:  1984       Impact factor: 2.176

4.  Reaction of N-n-butyl-N-nitrosourea with DNA in vitro.

Authors:  H Ortlieb; P Kleihues
Journal:  Carcinogenesis       Date:  1980       Impact factor: 4.944

5.  Specificity in carcinogen-DNA interaction: a theoretical exploration of the factors involved in the effect of neighboring bases on N-methyl-N-nitrosourea alkylation of DNA.

Authors:  S Furois-Corbin; B Pullman
Journal:  Chem Biol Interact       Date:  1985-06       Impact factor: 5.192

Review 6.  Biochemical significance of the hard and soft acids and bases principle.

Authors:  T L Ho; H C Ho; L D Hamilton
Journal:  Chem Biol Interact       Date:  1978-10       Impact factor: 5.192

7.  O4-ethyldeoxythymidine, but not O6-ethyldeoxyguanosine, accumulates in hepatocyte DNA of rats exposed continuously to diethylnitrosamine.

Authors:  J A Swenberg; M C Dyroff; M A Bedell; J A Popp; N Huh; U Kirstein; M F Rajewsky
Journal:  Proc Natl Acad Sci U S A       Date:  1984-03       Impact factor: 11.205

8.  Differential repair of O4-alkylthymidine following exposure to methylating and ethylating hepatocarcinogens.

Authors:  F C Richardson; M C Dyroff; J A Boucheron; J A Swenberg
Journal:  Carcinogenesis       Date:  1985-04       Impact factor: 4.944

9.  Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats.

Authors:  H Zarbl; S Sukumar; A V Arthur; D Martin-Zanca; M Barbacid
Journal:  Nature       Date:  1985 May 30-Jun 5       Impact factor: 49.962

10.  n-Propyldiazonium ion alkylates O6 of guanine with rearrangement, but alkylates N-7 without rearrangement.

Authors:  J D Scribner; G P Ford
Journal:  Cancer Lett       Date:  1982 May-Jun       Impact factor: 8.679
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