Literature DB >> 3923365

Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats.

H Zarbl, S Sukumar, A V Arthur, D Martin-Zanca, M Barbacid.   

Abstract

Induction of mammary carcinomas in rats by a single exposure to a carcinogen during sexual development often involves malignant activation of the Ha-ras-1 locus. Each of the Ha-ras-1 oncogenes present in tumours induced by N-nitroso-N-methylurea, but not in those induced by 7,12-dimethylbenz(a)anthracene, became activated by the same G----A transition, the type of mutation induced by N-nitroso-N-methylurea. These results are consistent with the notion that Ha-ras-1 oncogenes are directly activated by the carcinogen during initiation of neoplasia.

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Year:  1985        PMID： 3923365     DOI： 10.1038/315382a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  166 in total

1.  The enigma of carcinogenesis - stroma or epithelial cells?

Authors:  Rita Mulherkar
Journal:  J Biosci       Date:  2004-06       Impact factor: 1.826

2.  High-resolution structure of a mutagenic lesion in DNA.

Authors:  G A Leonard; J Thomson; W P Watson; T Brown
Journal:  Proc Natl Acad Sci U S A       Date:  1990-12       Impact factor: 11.205

3.  The cellular ecology of progressive neoplastic transformation: a clonal analysis.

Authors:  M Chow; H Rubin
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-02       Impact factor: 11.205

4.  Carcinogen-induced mutations in the mouse c-Ha-ras gene provide evidence of multiple pathways for tumor progression.

Authors:  K Brown; A Buchmann; A Balmain
Journal:  Proc Natl Acad Sci U S A       Date:  1990-01       Impact factor: 11.205

5.  Mutagenic specificity of N-methyl-N'-nitro-N-nitrosoguanidine in the gpt gene on a chromosome of Chinese hamster ovary cells and of Escherichia coli cells.

Authors:  H Sockett; S Romac; F Hutchinson
Journal:  Mol Gen Genet       Date:  1991-06

6.  Ras levels and metalloproteinase activity in normal versus neoplastic rat mammary tissues.

Authors:  M Ballin; A R Mackay; J L Hartzler; A Nason; M D Pelina; U P Thorgeirsson
Journal:  Clin Exp Metastasis       Date:  1991 Mar-Apr       Impact factor: 5.150

7.  Site-specific mutagenesis by O6-alkylguanines located in the chromosomes of mammalian cells: influence of the mammalian O6-alkylguanine-DNA alkyltransferase.

Authors:  K S Ellison; E Dogliotti; T D Connors; A K Basu; J M Essigmann
Journal:  Proc Natl Acad Sci U S A       Date:  1989-11       Impact factor: 11.205

Review 8.  N-Methyl-N-nitrosourea as a mammary carcinogenic agent.

Authors:  Ana I Faustino-Rocha; Rita Ferreira; Paula A Oliveira; Adelina Gama; Mário Ginja
Journal:  Tumour Biol       Date:  2015-09-19

9.  Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo.

Authors:  A I Robles; M L Rodriguez-Puebla; A B Glick; C Trempus; L Hansen; P Sicinski; R W Tennant; R A Weinberg; S H Yuspa; C J Conti
Journal:  Genes Dev       Date:  1998-08-15       Impact factor: 11.361

10.  Relating aromatic hydrocarbon-induced DNA adducts and c-H-ras mutations in mouse skin papillomas: the role of apurinic sites.

Authors:  D Chakravarti; J C Pelling; E L Cavalieri; E G Rogan
Journal:  Proc Natl Acad Sci U S A       Date:  1995-10-24       Impact factor: 11.205
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