Ranit Hizkiyahu1,2, Eva Suarthana3, Einav Kadour Peero4,5, Ido Feferkorn4,5, William Buckett4,5. 1. Department of Obstetrics and Gynecology, Royal Victoria Hospital, McGill University, Quebec, Montreal, Canada. ranithizk@gmail.com. 2. MUHC Reproductive Centre, 888, Blvd. de Maisonneuve East, Suite 200, H2L 4S8, Montreal, Quebec, Canada. ranithizk@gmail.com. 3. Department of Obstetrics and Gynecology, McGill University, Quebec, Montreal, Canada. 4. Department of Obstetrics and Gynecology, Royal Victoria Hospital, McGill University, Quebec, Montreal, Canada. 5. MUHC Reproductive Centre, 888, Blvd. de Maisonneuve East, Suite 200, H2L 4S8, Montreal, Quebec, Canada.
Abstract
OBJECTIVE: To assess the effect of increasing estrogen doses during hormone therapy frozen embryo transfer (HT-FET) cycles on endometrial thickness and success rates compared to patients who received fixed estrogen dose. MATERIALS AND METHODS: A retrospective study from a university-based fertility clinic during the years 2008-2021. We compared two groups: the fixed-dose group (i.e., received 6 mg estradiol dose daily until embryo transfer) and the increased-dose group (i.e., the initial estradiol dose was 6 mg daily, and was increased during the cycle). PRIMARY OUTCOME: clinical pregnancy rate. RESULTS: The study included 5452 cycles of HT-FET: 4774 cycles in the fixed-dose group and 678 cycles in the increased-dose group. Ultrasound scan on days 2-3 of the cycle showed endometrial thickness slightly different between the two groups (4.2 mm in the fixed-dose and 4.0 mm in the increased-dose group, P = 0.003). The total estrogen dose was higher, and the treatment duration was longer in the increased than the fixed-dose group (122 mg vs. 66 mg and 17 days vs. 11 days, respectively; P < 0.001). The last ultrasound scan done before the addition of progesterone showed that the endometrial thickness was significantly thicker in the fixed than the increased-dose group (9.5 mm vs. 8.3 mm; P < 0.001). The clinical pregnancy rates were 35.8% in the increased-group vs. 34.1% in the fixed-dose group; P = 0.401. CONCLUSIONS: The increased-dose group had thinner endometrium despite the higher doses of estrogen and longer treatment duration than the fixed-dose group. However, the pregnancy rates were similar between the two groups.
OBJECTIVE: To assess the effect of increasing estrogen doses during hormone therapy frozen embryo transfer (HT-FET) cycles on endometrial thickness and success rates compared to patients who received fixed estrogen dose. MATERIALS AND METHODS: A retrospective study from a university-based fertility clinic during the years 2008-2021. We compared two groups: the fixed-dose group (i.e., received 6 mg estradiol dose daily until embryo transfer) and the increased-dose group (i.e., the initial estradiol dose was 6 mg daily, and was increased during the cycle). PRIMARY OUTCOME: clinical pregnancy rate. RESULTS: The study included 5452 cycles of HT-FET: 4774 cycles in the fixed-dose group and 678 cycles in the increased-dose group. Ultrasound scan on days 2-3 of the cycle showed endometrial thickness slightly different between the two groups (4.2 mm in the fixed-dose and 4.0 mm in the increased-dose group, P = 0.003). The total estrogen dose was higher, and the treatment duration was longer in the increased than the fixed-dose group (122 mg vs. 66 mg and 17 days vs. 11 days, respectively; P < 0.001). The last ultrasound scan done before the addition of progesterone showed that the endometrial thickness was significantly thicker in the fixed than the increased-dose group (9.5 mm vs. 8.3 mm; P < 0.001). The clinical pregnancy rates were 35.8% in the increased-group vs. 34.1% in the fixed-dose group; P = 0.401. CONCLUSIONS: The increased-dose group had thinner endometrium despite the higher doses of estrogen and longer treatment duration than the fixed-dose group. However, the pregnancy rates were similar between the two groups.
Authors: Alexis K Masbou; Jenna B Friedenthal; David H McCulloh; Caroline McCaffrey; M Elizabeth Fino; James A Grifo; Frederick Licciardi Journal: Reprod Sci Date: 2018-12-20 Impact factor: 3.060
Authors: Danilo Cimadomo; Daria Soscia; Alberto Vaiarelli; Roberta Maggiulli; Antonio Capalbo; Filippo Maria Ubaldi; Laura Rienzi Journal: Hum Reprod Date: 2019-07-08 Impact factor: 6.918
Authors: Jigal Haas; Ramsey Smith; Eran Zilberberg; Dan Nayot; James Meriano; Eran Barzilay; Robert F Casper Journal: Fertil Steril Date: 2019-06-24 Impact factor: 7.329