Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Teaching an old dog new tricks: Drug discovery by repositioning natural products and their derivatives.

Literature DB >> 35182736

Teaching an old dog new tricks: Drug discovery by repositioning natural products and their derivatives.

Abstract

Given the substantial cost and low success rate of drug discovery and development, repositioning existing drugs to treat new diseases has gained significant attention in recent years, with potentially lower development costs and shorter time frames. Natural products show great promise in drug repositioning because they have been used for various medical purposes for thousands of years. In this review, we discuss the drug repositioning of six prototypical natural products and their derivatives to reveal new drug-disease associations. We also highlight opportunities and challenges in natural product-based drug repositioning for future reference.

Entities: Chemical

Keywords: Drug discovery and development; Drug repositioning; Natural products; New drug-disease associations

Mesh：

Substances：
Biological Products

Year: 2022 PMID： 35182736 PMCID： PMC9232944 DOI： 10.1016/j.drudis.2022.02.007

Source DB: PubMed Journal: Drug Discov Today ISSN： 1359-6446 Impact factor: 8.369

61 in total

Review 1. Drug repositioning: identifying and developing new uses for existing drugs.

Authors: Ted T Ashburn; Karl B Thor
Journal: Nat Rev Drug Discov Date: 2004-08 Impact factor: 84.694

Review 2. Lessons from natural molecules.

Authors: Jon Clardy; Christopher Walsh
Journal: Nature Date: 2004-12-16 Impact factor: 49.962

Review 3. Natural products in drug discovery and development.

Authors: G M Cragg; D J Newman; K M Snader
Journal: J Nat Prod Date: 1997-01 Impact factor: 4.050

4. Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019.

Authors: David J Newman; Gordon M Cragg
Journal: J Nat Prod Date: 2020-03-12 Impact factor: 4.050

Review 5. Beyond the Rule of 5: Lessons Learned from AbbVie's Drugs and Compound Collection.

Authors: David A DeGoey; Hui-Ju Chen; Philip B Cox; Michael D Wendt
Journal: J Med Chem Date: 2017-09-27 Impact factor: 7.446

6. Neuroprotective Effect of Artesunate in Experimental Model of Traumatic Brain Injury.

Authors: Enrico Gugliandolo; Ramona D'Amico; Marika Cordaro; Roberta Fusco; Rosalba Siracusa; Rosalia Crupi; Daniela Impellizzeri; Salvatore Cuzzocrea; Rosanna Di Paola
Journal: Front Neurol Date: 2018-07-31 Impact factor: 4.003

Review 7. Health-related quality of life after TBI: a systematic review of study design, instruments, measurement properties, and outcome.

Authors: Suzanne Polinder; Juanita A Haagsma; David van Klaveren; Ewout W Steyerberg; Ed F van Beeck
Journal: Popul Health Metr Date: 2015-02-17

2. Anti-Inflammatory Effects of Psoralen Derivatives on RAW264.7 Cells via Regulation of the NF-κB and MAPK Signaling Pathways.

Authors: Yeji Lee; Chang-Gu Hyun
Journal: Int J Mol Sci Date: 2022-05-22 Impact factor: 6.208

Review 3. Progress and Impact of Latin American Natural Product Databases.

Authors: Alejandro Gómez-García; José L Medina-Franco
Journal: Biomolecules Date: 2022-08-30

3 in total