BACKGROUND: Survivors from Ebola virus disease (EVD) may be at the origin of EVD resurgence. METHODS: Simultaneous reactivity to at least 2 Ebola virus or Zaire ebolavirus (EBOV) antigens was detected in 11 of 488 (2.3%; 95% confidence interval [CI], 1.1-4.0) suspected EVD patients who were discharged as negative after 2 consecutive negative tests during the 10th Ebola outbreak in the Democratic Republic of the Congo. RESULTS: After extrapolating the total number of individuals discharged as negative during the entire outbreak, we estimated a total of 1314 additional missed Ebola cases. CONCLUSIONS: These findings emphasize the usefulness of an EBOV serology analysis and the importance of extending epidemic surveillance to clinically suspected cases who were discharged as negative.
BACKGROUND: Survivors from Ebola virus disease (EVD) may be at the origin of EVD resurgence. METHODS: Simultaneous reactivity to at least 2 Ebola virus or Zaire ebolavirus (EBOV) antigens was detected in 11 of 488 (2.3%; 95% confidence interval [CI], 1.1-4.0) suspected EVD patients who were discharged as negative after 2 consecutive negative tests during the 10th Ebola outbreak in the Democratic Republic of the Congo. RESULTS: After extrapolating the total number of individuals discharged as negative during the entire outbreak, we estimated a total of 1314 additional missed Ebola cases. CONCLUSIONS: These findings emphasize the usefulness of an EBOV serology analysis and the importance of extending epidemic surveillance to clinically suspected cases who were discharged as negative.
Authors: Chad R Wells; Abhishek Pandey; Martial L Ndeffo Mbah; Bernard-A Gaüzère; Denis Malvy; Burton H Singer; Alison P Galvani Journal: Proc Natl Acad Sci U S A Date: 2019-10-21 Impact factor: 11.205
Authors: E M Leroy; S Baize; V E Volchkov; S P Fisher-Hoch; M C Georges-Courbot; J Lansoud-Soukate; M Capron; P Debré; J B McCormick; A J Georges Journal: Lancet Date: 2000-06-24 Impact factor: 79.321
Authors: Judith R Glynn; Hilary Bower; Sembia Johnson; Catherine F Houlihan; Carla Montesano; Janet T Scott; Malcolm G Semple; Mohammed S Bangura; Alie Joshua Kamara; Osman Kamara; Saidu H Mansaray; Daniel Sesay; Cecilia Turay; Steven Dicks; Raoul E Guetiya Wadoum; Vittorio Colizzi; Francesco Checchi; Dhan Samuel; Richard S Tedder Journal: Lancet Infect Dis Date: 2017-02-28 Impact factor: 25.071
Authors: Alpha Kabinet Keita; Fara R Koundouno; Martin Faye; Ariane Düx; Julia Hinzmann; Haby Diallo; Ahidjo Ayouba; Frederic Le Marcis; Barré Soropogui; Kékoura Ifono; Moussa M Diagne; Mamadou S Sow; Joseph A Bore; Sebastien Calvignac-Spencer; Nicole Vidal; Jacob Camara; Mamadou B Keita; Annick Renevey; Amadou Diallo; Abdoul K Soumah; Saa L Millimono; Almudena Mari-Saez; Mamadou Diop; Ahmadou Doré; Fodé Y Soumah; Kaka Kourouma; Nathalie J Vielle; Cheikh Loucoubar; Ibrahima Camara; Karifa Kourouma; Giuditta Annibaldis; Assaïtou Bah; Anke Thielebein; Meike Pahlmann; Steven T Pullan; Miles W Carroll; Joshua Quick; Pierre Formenty; Anais Legand; Karla Pietro; Michael R Wiley; Noel Tordo; Christophe Peyrefitte; John T McCrone; Andrew Rambaut; Youssouf Sidibé; Mamadou D Barry; Madeleine Kourouma; Cé D Saouromou; Mamadou Condé; Moussa Baldé; Moriba Povogui; Sakoba Keita; Mandiou Diakite; Mamadou S Bah; Amadou Sidibe; Dembo Diakite; Fodé B Sako; Fodé A Traore; Georges A Ki-Zerbo; Philippe Lemey; Stephan Günther; Liana E Kafetzopoulou; Amadou A Sall; Eric Delaporte; Sophie Duraffour; Ousmane Faye; Fabian H Leendertz; Martine Peeters; Abdoulaye Toure; N' Faly Magassouba Journal: Nature Date: 2021-09-15 Impact factor: 49.962
Authors: François Boillot; Laetitia Serrano; Jeremie Muwonga; Jean Pierre Kabuayi; Alain Kambale; Fidèle Mutaka; Paula I Fujiwara; Josef Decosas; Martine Peeters; Eric Delaporte Journal: J Acquir Immune Defic Syndr Date: 2016-01-01 Impact factor: 3.731
Authors: David M Pigott; Nick Golding; Adrian Mylne; Zhi Huang; Andrew J Henry; Daniel J Weiss; Oliver J Brady; Moritz U G Kraemer; David L Smith; Catherine L Moyes; Samir Bhatt; Peter W Gething; Peter W Horby; Isaac I Bogoch; John S Brownstein; Sumiko R Mekaru; Andrew J Tatem; Kamran Khan; Simon I Hay Journal: Elife Date: 2014-09-08 Impact factor: 8.140