| Literature DB >> 34526718 |
Alpha Kabinet Keita1,2, Fara R Koundouno3,4, Martin Faye5, Ariane Düx6, Julia Hinzmann4,7,8, Haby Diallo9, Ahidjo Ayouba10, Frederic Le Marcis9,10,11, Barré Soropogui3, Kékoura Ifono3,4, Moussa M Diagne5, Mamadou S Sow9,12, Joseph A Bore3,13, Sebastien Calvignac-Spencer6, Nicole Vidal10, Jacob Camara3, Mamadou B Keita14, Annick Renevey4,7, Amadou Diallo5, Abdoul K Soumah9, Saa L Millimono3,4, Almudena Mari-Saez6, Mamadou Diop5, Ahmadou Doré3, Fodé Y Soumah12, Kaka Kourouma14, Nathalie J Vielle4,15, Cheikh Loucoubar5, Ibrahima Camara9, Karifa Kourouma3,4, Giuditta Annibaldis4,15, Assaïtou Bah3, Anke Thielebein4,7, Meike Pahlmann4,7, Steven T Pullan8,13, Miles W Carroll8,13, Joshua Quick16, Pierre Formenty17, Anais Legand17, Karla Pietro18, Michael R Wiley18,19, Noel Tordo20, Christophe Peyrefitte5, John T McCrone21, Andrew Rambaut21, Youssouf Sidibé22, Mamadou D Barry22, Madeleine Kourouma22, Cé D Saouromou22, Mamadou Condé22, Moussa Baldé12, Moriba Povogui9, Sakoba Keita23, Mandiou Diakite24,25, Mamadou S Bah24, Amadou Sidibe11, Dembo Diakite12, Fodé B Sako12, Fodé A Traore12, Georges A Ki-Zerbo15, Philippe Lemey26, Stephan Günther4,7,15, Liana E Kafetzopoulou4,7,26, Amadou A Sall5, Eric Delaporte10,27, Sophie Duraffour4,7,15, Ousmane Faye5, Fabian H Leendertz6, Martine Peeters10, Abdoulaye Toure9,14, N' Faly Magassouba3.
Abstract
Seven years after the declaration of the first epidemic of Ebola virus disease in Guinea, the country faced a new outbreak-between 14 February and 19 June 2021-near the epicentre of the previous epidemic1,2. Here we use next-generation sequencing to generate complete or near-complete genomes of Zaire ebolavirus from samples obtained from 12 different patients. These genomes form a well-supported phylogenetic cluster with genomes from the previous outbreak, which indicates that the new outbreak was not the result of a new spillover event from an animal reservoir. The 2021 lineage shows considerably lower divergence than would be expected during sustained human-to-human transmission, which suggests a persistent infection with reduced replication or a period of latency. The resurgence of Zaire ebolavirus from humans five years after the end of the previous outbreak of Ebola virus disease reinforces the need for long-term medical and social care for patients who survive the disease, to reduce the risk of re-emergence and to prevent further stigmatization.Entities:
Mesh：
Year: 2021 PMID： 34526718 DOI： 10.1038/s41586-021-03901-9
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962