Junghun Kim1, Jongmin Lee2, Jieun Park3, Sinjae Hyun4. 1. Bio-Medical Research Institute, Kyungpook National University and Hospital, Daegu, Korea. fainal2@naver.com. 2. Department of Radiology, Kyungpook National University and Hospital, 50, Sam-Duk 2 Ga, Jung Gu, Daegu, 700-721, Republic of Korea. jonglee@knu.ac.kr. 3. Nonlinear Dynamics Research Center, Kyungpook National University, Daegu, Republic of Korea. 4. Department of Biomedical Engineering, Mercer University, Macon, GA, 31207, USA.
Abstract
OBJECTIVE: This study aims to compare an electrocardiogram (ECG)-gated four-dimensional (4D) phase-contrast (PC) magnetic resonance imaging (MRI) technique and computational fluid dynamics (CFD) using variables controlled in a laboratory environment to minimize bias factors. MATERIALS AND METHODS: Data from 4D PC-MRI were compared with computational fluid dynamics using steady and pulsatile flows at various inlet velocities. Anatomically realistic models for a normal aorta, a penetrating atherosclerotic ulcer, and an abdominal aortic aneurysm were constructed using a three-dimensional printer. RESULTS: For the normal aorta model, the errors in the peak and the average velocities were within 5%. The peak velocities of the penetrating atherosclerotic ulcer and the abdominal aortic aneurysm models displayed a more extensive range of differences because of the high-speed and vortical fluid flows generated by the shape of the blood vessel. However, the average velocities revealed only relatively minor differences. CONCLUSIONS: This study compared the characteristics of PC-MRI and CFD through a phantom study that only included controllable experimental parameters. Based on these results, 4D PC-MRI and CFD are powerful tools for analyzing blood flow patterns in vivo. However, there is room for future developments to improve velocity measurement accuracy.
OBJECTIVE: This study aims to compare an electrocardiogram (ECG)-gated four-dimensional (4D) phase-contrast (PC) magnetic resonance imaging (MRI) technique and computational fluid dynamics (CFD) using variables controlled in a laboratory environment to minimize bias factors. MATERIALS AND METHODS: Data from 4D PC-MRI were compared with computational fluid dynamics using steady and pulsatile flows at various inlet velocities. Anatomically realistic models for a normal aorta, a penetrating atherosclerotic ulcer, and an abdominal aortic aneurysm were constructed using a three-dimensional printer. RESULTS: For the normal aorta model, the errors in the peak and the average velocities were within 5%. The peak velocities of the penetrating atherosclerotic ulcer and the abdominal aortic aneurysm models displayed a more extensive range of differences because of the high-speed and vortical fluid flows generated by the shape of the blood vessel. However, the average velocities revealed only relatively minor differences. CONCLUSIONS: This study compared the characteristics of PC-MRI and CFD through a phantom study that only included controllable experimental parameters. Based on these results, 4D PC-MRI and CFD are powerful tools for analyzing blood flow patterns in vivo. However, there is room for future developments to improve velocity measurement accuracy.
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