Literature DB >> 3512995

Comparison of the mutagenic activity of 5-hydroxymethyldeoxyuridine with 5-substituted 2'-deoxyuridine analogs in the Ames Salmonella/microsome test.

M H Bilimoria, S V Gupta.   

Abstract

4 antiviral drugs 5-hydroxymethyldeoxyuridine (HMUdR), 5-trifluorothymidine (F3TdR), 5-methoxymethyldeoxyuridine (MMUdR) and 5-ethyldeoxyuridine (EtUdR) have been evaluated for mutagenic activity in the Ames Salmonella/microsome test. The antimetabolites F3TdR and HMUdR were mutagenic in a dose-dependent manner in strain TA100. F3TdR also was mutagenic in strain TA1535. Rat-liver post-mitochondrial supernatant (S9) was not required for mutagenicity.

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Year:  1986        PMID： 3512995     DOI： 10.1016/0165-1218(86)90091-1

Source DB:  PubMed          Journal:  Mutat Res        ISSN： 0027-5107            Impact factor:   2.433


  5 in total

1.  Site directed substitution of 5-hydroxymethyluracil for thymine in replicating phi X-174am3 DNA via synthesis of 5-hydroxymethyl-2'-deoxyuridine-5'-triphosphate.

Authors:  D D Levy; G W Teebor
Journal:  Nucleic Acids Res       Date:  1991-06-25       Impact factor: 16.971

2.  1H NMR studies of the 5-(hydroxymethyl)-2'-deoxyuridine containing TF1 binding site.

Authors:  L B Pasternack; J Bramham; L Mayol; A Galeone; X Jia; D R Kearns
Journal:  Nucleic Acids Res       Date:  1996-07-15       Impact factor: 16.971

3.  Quantification of oxidative DNA lesions in tissues of Long-Evans Cinnamon rats by capillary high-performance liquid chromatography-tandem mass spectrometry coupled with stable isotope-dilution method.

Authors:  Jin Wang; Bifeng Yuan; Candace Guerrero; Ralf Bahde; Sanjeev Gupta; Yinsheng Wang
Journal:  Anal Chem       Date:  2011-02-16       Impact factor: 6.986

4.  Synthesis of Oligonucleotides Containing 5-(Hydroxymethyl)-2'-deoxyuridine at Defined Sites.

Authors:  Lawrence C Sowers; G Peter Beardsley
Journal:  J Org Chem       Date:  1993       Impact factor: 4.198

5.  Identification of genotoxic compounds using isogenic DNA repair deficient DT40 cell lines on a quantitative high throughput screening platform.

Authors:  Kana Nishihara; Ruili Huang; Jinghua Zhao; Sampada A Shahane; Kristine L Witt; Stephanie L Smith-Roe; Raymond R Tice; Shunichi Takeda; Menghang Xia
Journal:  Mutagenesis       Date:  2015-08-04       Impact factor: 3.000
  5 in total

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