Literature DB >> 35859906

Synthesis of Oligonucleotides Containing 5-(Hydroxymethyl)-2'-deoxyuridine at Defined Sites.

Lawrence C Sowers1, G Peter Beardsley1.   

Abstract

A method is described for the solid-phase synthesis of oligonucleotides containing the DNA oxidation damage product, 5-(hydroxymethyl)-2'-deoxyuridine (HMdU) at selected sites using a phosphoramidite synthon regiospecifically protected on the 5-(hydroxymethyl) group.

Entities:  

Year:  1993        PMID： 35859906      PMCID： PMC9295613          DOI： 10.1021/jo00059a011

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.198


  13 in total

1.  Modification of DNA bases in mammalian chromatin by radiation-generated free radicals.

Authors:  E Gajewski; G Rao; Z Nackerdien; M Dizdaroglu
Journal:  Biochemistry       Date:  1990-08-28       Impact factor: 3.162

2.  Radiation-induced DNA damage and its repair.

Authors:  R Téoule
Journal:  Int J Radiat Biol Relat Stud Phys Chem Med       Date:  1987-04

3.  Effects of 5-hydroxymethyluracil and 3-aminobenzamide on the repair and toxicity of 5-hydroxymethyl-2'-deoxyuridine in mammalian cells.

Authors:  R J Boorstein; G W Teebor
Journal:  Cancer Res       Date:  1989-03-15       Impact factor: 12.701

4.  Synthesis and biological activities of 5-(hydroxymethyl, azidomethyl, or aminomethyl)-2'-deoxyuridine and related 5'-substituted analogues.

Authors:  G T Shiau; R F Schinazi; M S Chen; W H Prusoff
Journal:  J Med Chem       Date:  1980-02       Impact factor: 7.446

5.  Deoxyribonucleic acid synthesis in bacteriophage SP01-infected Bacillus subtilis. II. Purification and catalytic properties of a deoxyribonucleic acid polymerase induced after infection.

Authors:  C O Yehle; A T Ganesan
Journal:  J Biol Chem       Date:  1973-11-10       Impact factor: 5.157

6.  Site directed substitution of 5-hydroxymethyluracil for thymine in replicating phi X-174am3 DNA via synthesis of 5-hydroxymethyl-2'-deoxyuridine-5'-triphosphate.

Authors:  D D Levy; G W Teebor
Journal:  Nucleic Acids Res       Date:  1991-06-25       Impact factor: 16.971

7.  Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair.

Authors:  H Kasai; P F Crain; Y Kuchino; S Nishimura; A Ootsuyama; H Tanooka
Journal:  Carcinogenesis       Date:  1986-11       Impact factor: 4.944

8.  In vitro and in vivo studies of a promising antileukemic thymidine analogue, 5-hydroxymethyl-2' deoxyuridine.

Authors:  L Kahilainen; D Bergstrom; L Kangas; J A Vilpo
Journal:  Biochem Pharmacol       Date:  1986-12-01       Impact factor: 5.858

9.  Quantitative high-performance liquid chromatography analysis of DNA oxidized in vitro and in vivo.

Authors:  K Frenkel; Z J Zhong; H C Wei; J Karkoszka; U Patel; K Rashid; M Georgescu; J J Solomon
Journal:  Anal Biochem       Date:  1991-07       Impact factor: 3.365

10.  Genetic effects of 5-hydroxymethyl-2'-deoxyuridine, a product of ionizing radiation.

Authors:  L Shirnamé-Moré; T G Rossman; W Troll; G W Teebor; K Frenkel
Journal:  Mutat Res       Date:  1987-06       Impact factor: 2.433
View more
  1 in total

1.  Chemical and enzymatic modifications of 5-methylcytosine at the intersection of DNA damage, repair, and epigenetic reprogramming.

Authors:  Tuvshintugs Baljinnyam; Mark L Sowers; Chia Wei Hsu; James W Conrad; Jason L Herring; Linda C Hackfeld; Lawrence C Sowers
Journal:  PLoS One       Date:  2022-08-29       Impact factor: 3.752
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.