| Literature DB >> 3512286 |
T Kambara, S Uchida, J Tanaka, S Shoji.
Abstract
Proteolytic enzymes of the guinea pig peritoneal exudate macrophages were investigated using synthetic fluorogenic peptide substrates. Among several enzymes, t-butyloxycarbonyl-phenylalanyl-seryl-arginine 4-methylcoumaryl-7-amide cleaving enzymes had the highest activity, and the activity in exudate macrophages was about 3 times stronger than that in resident macrophages. The molecular weight of the enzyme was around 35,000 and optimal pH around 6.5-7.0. It was inhibited by thiol-blocking reagents, suggesting a thiol protease.Entities:
Mesh：
Substances：
Year: 1986 PMID： 3512286 DOI： 10.1007/bf01952443
Source DB: PubMed Journal: Experientia ISSN： 0014-4754