| Literature DB >> 35120664 |
Bastien Nguyen1, Christopher Fong1, Anisha Luthra1, Shaleigh A Smith1, Renzo G DiNatale2, Subhiksha Nandakumar1, Henry Walch1, Walid K Chatila1, Ramyasree Madupuri1, Ritika Kundra1, Craig M Bielski3, Brooke Mastrogiacomo1, Mark T A Donoghue4, Adrienne Boire5, Sarat Chandarlapaty6, Karuna Ganesh7, James J Harding8, Christine A Iacobuzio-Donahue9, Pedram Razavi8, Ed Reznik1, Charles M Rudin7, Dmitriy Zamarin8, Wassim Abida10, Ghassan K Abou-Alfa10, Carol Aghajanian10, Andrea Cercek10, Ping Chi10, Darren Feldman10, Alan L Ho10, Gopakumar Iyer10, Yelena Y Janjigian10, Michael Morris10, Robert J Motzer10, Eileen M O'Reilly10, Michael A Postow10, Nitya P Raj10, Gregory J Riely10, Mark E Robson10, Jonathan E Rosenberg10, Anton Safonov10, Alexander N Shoushtari10, William Tap10, Min Yuen Teo10, Anna M Varghese10, Martin Voss10, Rona Yaeger10, Marjorie G Zauderer10, Nadeem Abu-Rustum11, Julio Garcia-Aguilar11, Bernard Bochner11, Abraham Hakimi11, William R Jarnagin11, David R Jones11, Daniela Molena11, Luc Morris11, Eric Rios-Doria11, Paul Russo11, Samuel Singer11, Vivian E Strong11, Debyani Chakravarty12, Lora H Ellenson12, Anuradha Gopalan12, Jorge S Reis-Filho12, Britta Weigelt12, Marc Ladanyi12, Mithat Gonen13, Sohrab P Shah13, Joan Massague14, Jianjiong Gao1, Ahmet Zehir12, Michael F Berger15, David B Solit16, Samuel F Bakhoum17, Francisco Sanchez-Vega18, Nikolaus Schultz19.
Abstract
Metastatic progression is the main cause of death in cancer patients, whereas the underlying genomic mechanisms driving metastasis remain largely unknown. Here, we assembled MSK-MET, a pan-cancer cohort of over 25,000 patients with metastatic diseases. By analyzing genomic and clinical data from this cohort, we identified associations between genomic alterations and patterns of metastatic dissemination across 50 tumor types. We found that chromosomal instability is strongly correlated with metastatic burden in some tumor types, including prostate adenocarcinoma, lung adenocarcinoma, and HR+/HER2+ breast ductal carcinoma, but not in others, including colorectal cancer and high-grade serous ovarian cancer, where copy-number alteration patterns may be established early in tumor development. We also identified somatic alterations associated with metastatic burden and specific target organs. Our data offer a valuable resource for the investigation of the biological basis for metastatic spread and highlight the complex role of chromosomal instability in cancer progression.Entities:
Keywords: DNA sequencing; cancer; clinical sequencing; genomics; metastasis; molecular profiling; mutations; next-generation sequencing; organotropism; pan-cancer
Mesh：
Year: 2022 PMID： 35120664 PMCID： PMC9147702 DOI： 10.1016/j.cell.2022.01.003
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 66.850