INTRODUCTION: How can non-cultured platelet-rich plasma (PRP) therapy be the ultimate intervention in the treatment of total knee arthroplasty (TKA) -adaptive levels of knee osteoarthritis, as opposed to stem cell therapy that requires culture? METHODS: An intra-articular injection of leukocyte-rich PRP (LR-PRP) was administered to 260 patients every 4 weeks for over four times (mean 5.8 times); they were followed up for a maximum of 24 months. The clinical evaluation used the Knee Injury and Osteoarthritis Outcome Score, visual analogue scale, and magnetic resonance imaging osteoarthritis knee score-body mass lesions to determine the therapeutic effect using the Outcome Measures in Rheumatology-Osteoarthritis Research Society International responder criteria for osteoarthritis. RESULTS: Among those administered with LR-PRP, the responder rate was 72.0%, 78.1%, 78.1%, and 77.1% at 3, 6, 12, and 24 months, respectively. CONCLUSIONS: Our manually prepared LR-PRP was effective following multiple consecutive injections, despite severe degeneration.
INTRODUCTION: How can non-cultured platelet-rich plasma (PRP) therapy be the ultimate intervention in the treatment of total knee arthroplasty (TKA) -adaptive levels of knee osteoarthritis, as opposed to stem cell therapy that requires culture? METHODS: An intra-articular injection of leukocyte-rich PRP (LR-PRP) was administered to 260 patients every 4 weeks for over four times (mean 5.8 times); they were followed up for a maximum of 24 months. The clinical evaluation used the Knee Injury and Osteoarthritis Outcome Score, visual analogue scale, and magnetic resonance imaging osteoarthritis knee score-body mass lesions to determine the therapeutic effect using the Outcome Measures in Rheumatology-Osteoarthritis Research Society International responder criteria for osteoarthritis. RESULTS: Among those administered with LR-PRP, the responder rate was 72.0%, 78.1%, 78.1%, and 77.1% at 3, 6, 12, and 24 months, respectively. CONCLUSIONS: Our manually prepared LR-PRP was effective following multiple consecutive injections, despite severe degeneration.
Keywords:
Bone marrow lesion; Bone marrow lesion, BML; Consecutive injection; Leukocyte-rich platelet-rich plasma; Leukocyte-rich platelet-rich plasma, LR-PRP; Magnetic resonance imaging knee osteoarthritis knee score; Magnetic resonance imaging, MRI; Outcome Measures in rheumatology-osteoarthritis research society international; Outcome Measures in rheumatology-osteoarthritis research society international, OMERACT-OARSI; Severe degeneration; total knee arthroplasty, TKA
Authors: Iain R Murray; Andrew G Geeslin; Ewan B Goudie; Frank A Petrigliano; Robert F LaPrade Journal: J Bone Joint Surg Am Date: 2017-05-17 Impact factor: 5.284
Authors: T Pham; D van der Heijde; R D Altman; J J Anderson; N Bellamy; M Hochberg; L Simon; V Strand; T Woodworth; M Dougados Journal: Osteoarthritis Cartilage Date: 2004-05 Impact factor: 6.576