| Literature DB >> 35115689 |
Michael Inouye1,2,3,4,5,6,7, Guillaume Méric8,9, Youwen Qin10,11, Aki S Havulinna12,13, Yang Liu10,14, Pekka Jousilahti12, Scott C Ritchie10,15,16, Alex Tokolyi17, Jon G Sanders18,19, Liisa Valsta12, Marta Brożyńska10, Qiyun Zhu20, Anupriya Tripathi20,21, Yoshiki Vázquez-Baeza22,23, Rohit Loomba24, Susan Cheng25, Mohit Jain20,22, Teemu Niiranen12,26, Leo Lahti27, Rob Knight20,22,23, Veikko Salomaa12.
Abstract
Human genetic variation affects the gut microbiota through a complex combination of environmental and host factors. Here we characterize genetic variations associated with microbial abundances in a single large-scale population-based cohort of 5,959 genotyped individuals with matched gut microbial metagenomes, and dietary and health records (prevalent and follow-up). We identified 567 independent SNP-taxon associations. Variants at the LCT locus associated with Bifidobacterium and other taxa, but they differed according to dairy intake. Furthermore, levels of Faecalicatena lactaris associated with ABO, and suggested preferential utilization of secreted blood antigens as energy source in the gut. Enterococcus faecalis levels associated with variants in the MED13L locus, which has been linked to colorectal cancer. Mendelian randomization analysis indicated a potential causal effect of Morganella on major depressive disorder, consistent with observational incident disease analysis. Overall, we identify and characterize the intricate nature of host-microbiota interactions and their association with disease.Entities:
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Year: 2022 PMID： 35115689 DOI： 10.1038/s41588-021-00991-z
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330