Literature DB >> 3511368

Isolation of glutathione-deficient mutants of the yeast Saccharomyces cerevisiae.

M Kistler, K H Summer, F Eckardt.   

Abstract

Glutathione-deficient (gsh-) mutants of the yeast Saccharomyces cerevisiae were isolated after UV treatment using MNNG as selective agent. For genetic and biochemical characterization 5 mutant strains were chosen which exhibited considerably decreased residual GSH contents varying from 2 to 6% of the wild-type levels. All 5 isolates showed a 2:2 segregation of the gsh-:GSH+ phenotypes alluding to a monogenic recessive mutation. Complementation analysis indicates that all gsh- mutants belong to one complementation group.

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Year:  1986        PMID： 3511368     DOI： 10.1016/0165-7992(86)90087-4

Source DB:  PubMed          Journal:  Mutat Res        ISSN： 0027-5107            Impact factor:   2.433


  12 in total

Review 1.  Maintenance and integrity of the mitochondrial genome: a plethora of nuclear genes in the budding yeast.

Authors:  V Contamine; M Picard
Journal:  Microbiol Mol Biol Rev       Date:  2000-06       Impact factor: 11.056

2.  Glutathione synthetase is dispensable for growth under both normal and oxidative stress conditions in the yeast Saccharomyces cerevisiae due to an accumulation of the dipeptide gamma-glutamylcysteine.

Authors:  C M Grant; F H MacIver; I W Dawes
Journal:  Mol Biol Cell       Date:  1997-09       Impact factor: 4.138

3.  A high copy number of yeast gamma-glutamylcysteine synthetase suppresses a nuclear mutation affecting mitochondrial translation.

Authors:  T Lisowsky
Journal:  Curr Genet       Date:  1993 May-Jun       Impact factor: 3.886

4.  A recessive mutant allele of the HNM1 gene of Saccharomyces cerevisiae is responsible for hyper-resistance to nitrogen mustard.

Authors:  E Haase; M Brendel
Journal:  Curr Genet       Date:  1990-10       Impact factor: 3.886

5.  Saccharomyces cerevisiae exhibits a yAP-1-mediated adaptive response to malondialdehyde.

Authors:  H E Turton; I W Dawes; C M Grant
Journal:  J Bacteriol       Date:  1997-02       Impact factor: 3.490

6.  Glutathione is an essential metabolite required for resistance to oxidative stress in the yeast Saccharomyces cerevisiae.

Authors:  C M Grant; F H MacIver; I W Dawes
Journal:  Curr Genet       Date:  1996-05       Impact factor: 3.886

7.  Isolation and characterization of additional genes influencing resistance to various mutagens in the yeast Saccharomyces cerevisiae.

Authors:  E Haase; J Servos; M Brendel
Journal:  Curr Genet       Date:  1992-04       Impact factor: 3.886

8.  Overexpression of the SNQ3/YAP1 gene confers hyper-resistance to nitrosoguanidine in Saccharomyces cerevisiae via a glutathione-independent mechanism.

Authors:  M Grey; M Brendel
Journal:  Curr Genet       Date:  1994-05       Impact factor: 3.886

9.  Isolation and characterization of sulfite mutants of Saccharomyces cerevisiae.

Authors:  X Xu; J D Wightman; B L Geller; D Avram; A T Bakalinsky
Journal:  Curr Genet       Date:  1994-06       Impact factor: 3.886

10.  Glutathione and glutathione metabolizing enzymes in yeasts.

Authors:  E Casalone; C Di Ilio; G Federici; M Polsinelli
Journal:  Antonie Van Leeuwenhoek       Date:  1988       Impact factor: 2.271
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