Literature DB >> 8082194

Overexpression of the SNQ3/YAP1 gene confers hyper-resistance to nitrosoguanidine in Saccharomyces cerevisiae via a glutathione-independent mechanism.

M Grey1, M Brendel.   

Abstract

The MNNG hyper-resistance of yeast transformants containing multiple copies of the SNQ3/YAP1 yeast gene is not caused by lowered MNNG activation due to depleted pools of glutathione. On the contrary, the SNQ3/YAP1-encoded protein stimulates production of GSH, apparently by promoter activation due to the AP-1 recognition element. Expression of at least one further gene, encoding a protein with a strong detoxifying activity, must also be stimulated to explain the MNNG hyper-resistance phenotype.

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Year:  1994        PMID： 8082194     DOI： 10.1007/bf00351788

Source DB:  PubMed          Journal:  Curr Genet        ISSN： 0172-8083            Impact factor:   3.886


  24 in total

Review 1.  Relationships between functionality and genetic toxicology of selected DNA-damaging agents.

Authors:  M Brendel; A Ruhland
Journal:  Mutat Res       Date:  1984-01       Impact factor: 2.433

2.  Characterization of PDR4, a Saccharomyces cerevisiae gene that confers pleiotropic drug resistance in high-copy number: identity with YAP1, encoding a transcriptional activator [corrected].

Authors:  M Hussain; J Lenard
Journal:  Gene       Date:  1991-05-15       Impact factor: 3.688

3.  Yeast YAP1 encodes a novel form of the jun family of transcriptional activator proteins.

Authors:  W S Moye-Rowley; K D Harshman; C S Parker
Journal:  Genes Dev       Date:  1989-03       Impact factor: 11.361

4.  [On the mechanism of action of 1-nitroso-3-nitro-1-methylguanidine (NNMG) in mutagenesis. IV. Stability of NNMG, relations between mutation rate and uptake of the mutagen by the cell, and requirement for methylation by sulfhydryl groups as a function of the pH value].

Authors:  R Süssmuth; F Lingens
Journal:  Z Naturforsch B       Date:  1969-07       Impact factor: 1.047

5.  Isolation and characterization of additional genes influencing resistance to various mutagens in the yeast Saccharomyces cerevisiae.

Authors:  E Haase; J Servos; M Brendel
Journal:  Curr Genet       Date:  1992-04       Impact factor: 3.886

6.  Methylation of deoxyribonucleic acid in cultured mammalian cells by N-methyl-N'-nitro-N-nitrosoguanidine. The influence of cellular thiol concentrations on the extent of methylation and the 6-oxygen atom of guanine as a site of methylation.

Authors:  P D Lawley; C J Thatcher
Journal:  Biochem J       Date:  1970-02       Impact factor: 3.857

7.  Gene SNQ2 of Saccharomyces cerevisiae, which confers resistance to 4-nitroquinoline-N-oxide and other chemicals, encodes a 169 kDa protein homologous to ATP-dependent permeases.

Authors:  J Servos; E Haase; M Brendel
Journal:  Mol Gen Genet       Date:  1993-01

8.  Isolation of glutathione-deficient mutants of the yeast Saccharomyces cerevisiae.

Authors:  M Kistler; K H Summer; F Eckardt
Journal:  Mutat Res       Date:  1986-02       Impact factor: 2.433

9.  The SNQ3 gene of Saccharomyces cerevisiae confers hyper-resistance to several functionally unrelated chemicals.

Authors:  K Hertle; E Haase; M Brendel
Journal:  Curr Genet       Date:  1991-06       Impact factor: 3.886

10.  Transcriptional activation by the SV40 AP-1 recognition element in yeast is mediated by a factor similar to AP-1 that is distinct from GCN4.

Authors:  K D Harshman; W S Moye-Rowley; C S Parker
Journal:  Cell       Date:  1988-04-22       Impact factor: 41.582
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  3 in total

1.  Crz1p Regulates pH Homeostasis in Candida glabrata by Altering Membrane Lipid Composition.

Authors:  Dongni Yan; Xiaobao Lin; Yanli Qi; Hui Liu; Xiulai Chen; Liming Liu; Jian Chen
Journal:  Appl Environ Microbiol       Date:  2016-09-23       Impact factor: 4.792

2.  Carnitine and carnitine acetyltransferases in the yeast Saccharomyces cerevisiae: a role for carnitine in stress protection.

Authors:  Jaco Franken; Sven Kroppenstedt; Jan H Swiegers; Florian F Bauer
Journal:  Curr Genet       Date:  2008-04-22       Impact factor: 3.886

3.  Integrating phenotypic and expression profiles to map arsenic-response networks.

Authors:  Astrid C Haugen; Ryan Kelley; Jennifer B Collins; Charles J Tucker; Changchun Deng; Cynthia A Afshari; J Martin Brown; Trey Ideker; Bennett Van Houten
Journal:  Genome Biol       Date:  2004-11-29       Impact factor: 13.583
  3 in total

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