Alison M Neff1, Mary J Laws1, Genoa R Warner1, Jodi A Flaws2. 1. Department of Comparative Biosciences, University of Illinois at Urbana-Champaign, 2001 South Lincoln Avenue, 3223 Vet Med Basic Sciences Bldg, Urbana, IL, 61802, USA. 2. Department of Comparative Biosciences, University of Illinois at Urbana-Champaign, 2001 South Lincoln Avenue, 3223 Vet Med Basic Sciences Bldg, Urbana, IL, 61802, USA. jflaws@illinois.edu.
Abstract
PURPOSE OF REVIEW: Menopause marks the end of a woman's reproductive lifetime. On average, natural menopause occurs at 51 years of age. However, some women report an earlier age of menopause than the national average. This can be problematic for women who delay starting a family. Moreover, early onset of menopause is associated with increased risk of cardiovascular disease, depression, osteoporosis, and premature death. This review investigates associations between exposure to endocrine-disrupting chemicals (EDCs) and earlier onset of menopause. RECENT FINDINGS: Recent data suggest exposure to certain EDCs may accelerate reproductive aging and contribute to earlier onset of menopause. Human and rodent-based studies identify positive associations between exposure to certain EDCs/environmental contaminants and reproductive aging, earlier onset of menopause, and occurrence of vasomotor symptoms. These findings increase our understanding of the detrimental effects of EDCs on female reproduction and will help lead to the development of strategies for the treatment/prevention of EDC-induced reproductive aging.
PURPOSE OF REVIEW: Menopause marks the end of a woman's reproductive lifetime. On average, natural menopause occurs at 51 years of age. However, some women report an earlier age of menopause than the national average. This can be problematic for women who delay starting a family. Moreover, early onset of menopause is associated with increased risk of cardiovascular disease, depression, osteoporosis, and premature death. This review investigates associations between exposure to endocrine-disrupting chemicals (EDCs) and earlier onset of menopause. RECENT FINDINGS: Recent data suggest exposure to certain EDCs may accelerate reproductive aging and contribute to earlier onset of menopause. Human and rodent-based studies identify positive associations between exposure to certain EDCs/environmental contaminants and reproductive aging, earlier onset of menopause, and occurrence of vasomotor symptoms. These findings increase our understanding of the detrimental effects of EDCs on female reproduction and will help lead to the development of strategies for the treatment/prevention of EDC-induced reproductive aging.
Authors: Cynthia A Stuenkel; Susan R Davis; Anne Gompel; Mary Ann Lumsden; M Hassan Murad; JoAnn V Pinkerton; Richard J Santen Journal: J Clin Endocrinol Metab Date: 2015-10-07 Impact factor: 5.958
Authors: Brian W Whitcomb; Alexandra C Purdue-Smithe; Kathleen L Szegda; Maegan E Boutot; Susan E Hankinson; JoAnn E Manson; Bernard Rosner; Walter C Willett; A Heather Eliassen; Elizabeth R Bertone-Johnson Journal: Am J Epidemiol Date: 2018-04-01 Impact factor: 4.897
Authors: Genoa R Warner; Diana C Pacyga; Rita S Strakovsky; Rebecca Smith; Tamarra James-Todd; Paige L Williams; Russ Hauser; Daryl D Meling; Zhong Li; Jodi A Flaws Journal: Environ Res Date: 2021-03-17 Impact factor: 8.431
Authors: Ayelet Ziv-Gal; Rebecca L Smith; Lisa Gallicchio; Susan R Miller; Howard A Zacur; Jodi A Flaws Journal: Womens Midlife Health Date: 2017-08-17
Authors: Stephanie J Frisbee; A Paul Brooks; Arthur Maher; Patsy Flensborg; Susan Arnold; Tony Fletcher; Kyle Steenland; Anoop Shankar; Sarah S Knox; Cecil Pollard; Joel A Halverson; Verónica M Vieira; Chuanfang Jin; Kevin M Leyden; Alan M Ducatman Journal: Environ Health Perspect Date: 2009-07-13 Impact factor: 9.031
Authors: Katarzyna Krajewska-Ferishah; Agnieszka Kułak-Bejda; Agnieszka Szyszko-Perłowska; Andrei Shpakou; Katarzyna Van Damme-Ostapowicz; Antigoni Chatzopulu Journal: J Clin Med Date: 2022-06-12 Impact factor: 4.964