Genoa R Warner1, Diana C Pacyga2, Rita S Strakovsky3, Rebecca Smith4, Tamarra James-Todd5, Paige L Williams6, Russ Hauser5, Daryl D Meling1, Zhong Li7, Jodi A Flaws8. 1. Department of Comparative Biosciences, University of Illinois, Urbana, IL, 61802, USA. 2. Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI, 48823, USA; Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, 48823, USA; Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI, 48823, USA. 3. Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI, 48823, USA; Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, 48823, USA. 4. Department of Pathobiology, University of Illinois, Urbana, IL, 61802, USA. 5. Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA. 6. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA. 7. Roy J. Carver Biotechnology Center, University of Illinois, Urbana, IL, 61801, USA. 8. Department of Comparative Biosciences, University of Illinois, Urbana, IL, 61802, USA; Institute for Genomic Biology, University of Illinois, Urbana, IL, 61802, USA. Electronic address: jflaws@illinois.edu.
Abstract
CONTEXT: Phthalate exposure is associated with altered reproductive function, but little is known about associations of phthalate exposure with risk of hot flashes. OBJECTIVE: To investigate associations of urinary phthalate metabolite levels with four hot flash outcomes in midlife women. DESIGN: A cross-sectional study of the first year of a prospective cohort of midlife women, the Midlife Women's Health Study (2006-2015), a convenience sample from an urban setting. PARTICIPANTS: 728 multi-racial/ethnic pre- and perimenopausal women aged 45-54 years. OUTCOME MEASURES: Women completed questionnaires about hot flash experience and provided 1-4 urine samples over four consecutive weeks that were pooled for analysis. Phthalate metabolites were assessed individually and as molar sums representative of common compounds (all phthalates: ƩPhthalates; DEHP: ƩDEHP), exposure sources (plastics: ƩPlastic; personal care products: ƩPCP), and modes of action (anti-androgenic: ƩAA). Covariate-adjusted logistic regression models were used to assess associations of continuous natural log-transformed phthalate metabolite concentrations with hot flash outcomes. Analyses were conducted to explore whether associations differed by menopause status, body mass index (BMI), race/ethnicity, and depressive symptoms. RESULTS: Overall, 45% of women reported a history of hot flashes. Compared to women who never experienced hot flashes, every two-fold increase in ƩPlastic was associated with 18% (OR: 1.18; 95%CI: 0.98, 1.43) and 38% (OR: 1.38; 95%CI: 1.11, 1.70) higher odds of experiencing hot flashes in the past 30 days and experiencing daily/weekly hot flashes, respectively. Some associations of phthalates with certain hot flash outcomes differed by menopause status, BMI, race/ethnicity, and depressive symptoms. CONCLUSIONS: This study suggests that phthalates are associated with hot flash experience and may impact hot flash risk in women who are susceptible to experiencing hot flashes.
CONTEXT: Phthalate exposure is associated with altered reproductive function, but little is known about associations of phthalate exposure with risk of hot flashes. OBJECTIVE: To investigate associations of urinary phthalate metabolite levels with four hot flash outcomes in midlife women. DESIGN: A cross-sectional study of the first year of a prospective cohort of midlife women, the Midlife Women's Health Study (2006-2015), a convenience sample from an urban setting. PARTICIPANTS: 728 multi-racial/ethnic pre- and perimenopausal women aged 45-54 years. OUTCOME MEASURES: Women completed questionnaires about hot flash experience and provided 1-4 urine samples over four consecutive weeks that were pooled for analysis. Phthalate metabolites were assessed individually and as molar sums representative of common compounds (all phthalates: ƩPhthalates; DEHP: ƩDEHP), exposure sources (plastics: ƩPlastic; personal care products: ƩPCP), and modes of action (anti-androgenic: ƩAA). Covariate-adjusted logistic regression models were used to assess associations of continuous natural log-transformed phthalate metabolite concentrations with hot flash outcomes. Analyses were conducted to explore whether associations differed by menopause status, body mass index (BMI), race/ethnicity, and depressive symptoms. RESULTS: Overall, 45% of women reported a history of hot flashes. Compared to women who never experienced hot flashes, every two-fold increase in ƩPlastic was associated with 18% (OR: 1.18; 95%CI: 0.98, 1.43) and 38% (OR: 1.38; 95%CI: 1.11, 1.70) higher odds of experiencing hot flashes in the past 30 days and experiencing daily/weekly hot flashes, respectively. Some associations of phthalates with certain hot flash outcomes differed by menopause status, BMI, race/ethnicity, and depressive symptoms. CONCLUSIONS: This study suggests that phthalates are associated with hot flash experience and may impact hot flash risk in women who are susceptible to experiencing hot flashes.
Authors: Lisa Gallicchio; Susan R Miller; Kala Visvanathan; Lynn M Lewis; Janice Babus; Howard Zacur; Jodi A Flaws Journal: Maturitas Date: 2006-01-20 Impact factor: 4.342
Authors: Kelly K Ferguson; Emma M Rosen; Zaira Rosario; Zlatan Feric; Antonia M Calafat; Thomas F McElrath; Carmen Vélez Vega; José F Cordero; Akram Alshawabkeh; John D Meeker Journal: Environ Int Date: 2019-08-17 Impact factor: 9.621
Authors: Jacqueline W H Biesterbos; Tatsiana Dudzina; Christiaan J E Delmaar; Martine I Bakker; Frans G M Russel; Natalie von Goetz; Paul T J Scheepers; Nel Roeleveld Journal: Food Chem Toxicol Date: 2012-11-19 Impact factor: 6.023
Authors: Daryl D Meling; Genoa R Warner; Jason R Szumski; Liying Gao; Andressa V Gonsioroski; Saniya Rattan; Jodi A Flaws Journal: Toxicol Appl Pharmacol Date: 2019-12-26 Impact factor: 4.219
Authors: John D Meeker; Stacey A Missmer; Larisa Altshul; Allison F Vitonis; Louise Ryan; Daniel W Cramer; Russ Hauser Journal: Environ Health Date: 2009-07-14 Impact factor: 5.984
Authors: Ayelet Ziv-Gal; Rebecca L Smith; Lisa Gallicchio; Susan R Miller; Howard A Zacur; Jodi A Flaws Journal: Womens Midlife Health Date: 2017-08-17
Authors: Karen K Chiu; Shah Tauseef Bashir; Ahmed M Abdel-Hamid; Lindsay V Clark; Mary J Laws; Isaac Cann; Romana A Nowak; Jodi A Flaws Journal: Toxics Date: 2022-02-06
Authors: Diana C Pacyga; Brad A Ryva; Romana A Nowak; Serdar E Bulun; Ping Yin; Zhong Li; Jodi A Flaws; Rita S Strakovsky Journal: Int J Environ Res Public Health Date: 2022-02-26 Impact factor: 3.390