Assessment of Future Hypertension Risk by Sex Using Combined Body Mass Index and Waist-to-Height Ratio.

Background: Body mass index (BMI) and the waist-to-height ratio (WHtR) are widely used anthropometric indices of obesity to predict cardiovascular risks. However, the usefulness of combining WHtR and BMI values to predict hypertension risk by sex has not been well elucidated. Methods and 
Results: This cohort study enrolled 45,921 participants (mean [±SD] age 53.8±10.5 years; 47.0% men) without hypertension from among those undergoing annual health checkups. Participants were divided into 4 categories based on median BMI and WHtR values, and the 5-year incidence of hypertension was assessed for both sexes using logistic regression analysis. Mean (±SD) BMI and WHtR values were 23.5±3.1 kg/m2 and 0.50±0.05, respectively, in men and 22.4±3.3 kg/m2 and 0.53±0.06, respectively, in women. Among the women, those with high BMI and low WHtR had an increased risk of hypertension compared with those with low BMI and low WHtR (odds ratio [OR] 1.37, P<0.001); however, the same result was not found in men (OR 1.14, P=0.080). In both sexes, the incidence of hypertension was higher among participants with low BMI and high WHtR than among those with low BMI and low WHtR (men: OR 1.26, P<0.001; women: OR 1.15, P=0.048). Conclusions: Using WHtR and BMI together provides a better hypertension risk assessment. Among men, those with a high BMI had no increased hypertension risk when WHtR was low.

Hypertension is one of the main risk factors for cardiovascular diseases and has high global prevalence, morbidity, and mortality., Thus, it is important to explore methods for primary prevention to reduce incident hypertension in the general population. Epidemiological studies have shown that hypertension is strongly associated with obesity; risk estimates suggest that 75% of hypertension is attributable to obesity. Imaging modalities such as magnetic resonance imaging and computed tomography are the gold standard for assessing body fat composition; however, anthropometric measurements are an easy method for primary screening of obesity and the risk of hypertension in research and clinical settings.

The World Health Organization (WHO) has used body mass index (BMI) and waist circumference (WC) values to evaluate obesity, even though the standards do not apply to all ethnic groups and may underestimate the magnitude of the obesity epidemic, specifically in Asians., BMI is unable to differentiate between fat-free mass and fat mass, and WC is limited by its isolation of height; there is strong evidence of an inverse relationship between height and health risks., In addition, WC has multiple ethnic and sex-specific thresholds., The waist-to-height ratio (WHtR) has been recommended in recent studies as a better tool for the evaluation of body fat distribution and the risk of cardiovascular disease than BMI and WC, with a universal boundary of 0.5., Studies and guidelines differ in recommendations regarding the best index to clinically measure adiposity; however, BMI, WC, and WHtR are all associated with a risk of hypertension and have shown similarities in strength across different sexes and races., Meanwhile, some studies have shown that WHtR is a better index for predicting future hypertension. Sex dimorphism in body fat distribution has been elaborated in previous studies, using imaging techniques and obesity indices to indicate that the pattern of fat distribution is more crucial than the degree of fat in determining cardiometabolic risk.

Previous studies have relied predominantly on the separate association of obesity indices with the risk of hypertension, and very few have examined whether the combination of measurements for the general distribution of body fat, measured by BMI, and the central distribution of body fat, measured by the WHtR, can contribute to better prediction of hypertension. A few robust studies have suggested that among BMI groups, participants with a high WC have an overall increased risk of adverse health outcomes compared with those with a normal WC., Furthermore, Pischon et al investigated the association between BMI, WC, and the risk of death among 359,387 adults from 9 countries and demonstrated that a combination of WC and BMI provided improved predictions of a health risk than either anthropometric measure alone. However, the effect of screening BMI and WHtR in combination on the risk of hypertension by sex remains to be elucidated.

In the present study, we retrospectively analyzed the health checkup data for the general Japanese population with the aim of investigating whether the combination of BMI and WHtR can better assess the risk of hypertension among men and women in this population.

Methods

Study Population

Data from Kagoshima Kouseiren Hospital for involving participants who underwent annual health checkups between October 1, 2008 and March 31, 2019 were used for analysis. Initially, participants aged 30–70 years who had a follow-up time of 5 years (range 3–7 years) and data regarding baseline characteristics were recruited to the study. All participants with missing data and those who were hypertensive were excluded from the study. Thus, 45,921 participants were included in the analysis. Because visits were not consecutive, we only used available baseline and follow-up data at Year 5 for our analysis. The data were anonymized and all participants were given an option to opt-out of the study.

This study complied with the Declaration of Helsinki and was approved by the Institutional Ethics Committee of the Graduate School of Medical and Dental Sciences, Kagoshima University.

Data Collection

Self-administered questionnaires were used to obtain information about current medications for hypertension, diabetes, and dyslipidemia, as well as details regarding smoking, alcohol consumption, and exercise. Participants were categorized as current (tobacco) smokers or non-smokers (those with no history of smoking or ex-smokers); alcohol consumption was categorized as habitual (i.e., daily alcohol intake) or occasional (i.e., participants who rarely or sometimes drank alcohol). An exercise habit was defined as an exercise regimen of ≥30 min once a week. Anthropometric measurements, including height, weight, and WC, were obtained using standard operating procedures established by the WHO. BMI was calculated as body weight (kg) divided by height squared (m). WHtR was calculated by dividing the WC of the participant by their height.

Blood pressure (BP) measurements were taken during enrollment and at subsequent visits. Brachial BP was measured in subjects in a seated position after 3–5 min rest in a quiet room, with an appropriately sized cuff on the right arm; the elbow was rested on a desk with the mid-arm at heart level. A well-trained staff member recorded the readings using a calibrated automated BP machine. During the annual health checkup, the BP reading was recorded only once.

Blood samples were obtained from patients after an overnight fasting. Serum triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), fasting plasma glucose (FPG), and creatinine levels were measured using standard laboratory procedures. Diabetes was defined as FPG ≥110 mg/dL or the use of antidiabetic medication; dyslipidemia was defined as elevated serum LDL-C ≥140 mg/dL or serum HDL-C <40 mg/dL or elevated serum TG ≥150 mg/dL or the use of lipid-lowering medications. The estimated glomerular filtration rate (eGFR) was determined according to the new Japanese coefficient for the modified isotope dilution mass spectrometry-traceable Modification of Diet in Renal Disease study equation as follows:

eGFR = 194 × SCr−1.094 × Age−0.287

where SCr is serum creatinine. For women, eGFR was multiplied by a correction factor of 0.739.

The incidence of hypertension during the 5-year follow-up was determined on the basis of the development of systolic BP (SBP) ≥140 mmHg and/or diastolic BP (DBP) ≥90 mmHg, or newly prescribed antihypertensive medication during the 5-year follow-up.

Anthropometric Measurement and Classification

BMI was used in the present study to define general obesity, whereas WHtR was used to define central obesity. Median BMI and WHtR values were used to classify participants into 4 groups based on whether they had low or high BMI and WHtR. Initially, BMI and WHtR were studied in the 4 separate groups (low BMI, high BMI, low WHtR, and high WHtR) in both sexes. Later, we classified all participants into 4 groups by combining their BMI and WHtR as follows: (1) low BMI+low WHtR; (2) high BMI+low WHtR; (3) low BMI+high WHtR; and (4) high BMI+high WHtR.

Statistical Analyses

All analyses were performed separately for men and women. The continuous variables age, height, weight, WC, BMI, WHtR, SBP, DBP, LDL-C, HDL-C, and eGFR are expressed as the mean±SD; TG and FPG are expressed as the median with interquartile range. Categorical variables (current tobacco smoking, habitual alcohol drinking, habitual exercise, and the use of medication) are presented as numbers and percentages.

The 5-year incidence of hypertension was also calculated. We initially analyzed BMI and WHtR separately to assess their association with the 5-year incidence of hypertension and determined their predictive ability using receiver operating characteristic (ROC) curves, comparing the area under the curve (AUC) between the two indices for each sex separately. The 5-year risk of hypertension was assessed separately in each low or high index (BMI and WHtR) group using univariate and multivariate logistic regression analysis, along with determination of odds ratios (OR) and 95% confidence intervals (CI). In multivariate logistic regression, we analyzed potential confounders using 3 different models: Model 1, age; Model 2, age and SBP; and Model 3, age, SBP, eGFR, current tobacco smoking, exercise habit, diabetes, and dyslipidemia. Furthermore, univariate and multivariate analyses were performed to assess 5-year risk of hypertension between the 4 BMI+WHtR combined categories by sex.

All statistical analyses were performed using the JMP Pro version 14 (SAS Institute, Cary, NC, USA) for Windows. Statistical significance was set at 2-tailed P<0.05.

Results

Baseline Characteristics

Of the 198,292 participants, 45,921 (21,570 [47.0%] men) were eligible for analysis ().

Figure 1.

Study population. Among 198,292 participants aged 30–70 years, 45,921 (21,570 [47.0%] men) were eligible for analysis. DBP, diastolic blood pressure; SBP, systolic blood pressure.

presents the baseline characteristics of the study population. Women were relatively older than men, but men had significantly higher baseline SBP, TG, and FPG, a higher proportion of current tobacco smokers and habitual alcohol drinkers, a lower proportion of participants with exercise habits, and a lower eGFR than women. After 5 years, the incidence of hypertension was higher in men than in women (19.2% vs. 14.2%, respectively; P<0.001).

Table 1.

Baseline Characteristics of the Study Population and the 5-Year Incidence of Hypertension

	All (n=45,921)	Men (n=21,570)	Women (n=24,351)	P value
Age (years)	53.8±10.5	52.7±10.7	54.8±10.1	<0.001
Height (cm)	159.9±9.0	166.8±6.6	153.7±5.9	<0.001
Weight (kg)	58.8±11.2	65.4±10.3	53.0±8.4	<0.001
WC (cm)	82.3±9.0	83.8±8.4	81.0±9.3	<0.001
BMI (kg/m2)	22.9±3.3	23.5±3.1	22.4±3.3	<0.001
WHtR	0.52±0.06	0.50±0.05	0.53±0.06	<0.001
SBP (mmHg)	117.0±12.8	118.3±11.8	115.8±13.4	<0.001
DBP (mmHg)	72.8±8.7	74.4±8.4	71.3±8.8	<0.001
Triglycerides (mg/dL)	87 [62–27]	102 [71–152]	77 [57–107]	<0.001
HDL-C (mg/dL)	60.4±14.9	55.9±14.2	64.4±14.4	<0.001
LDL-C (mg/dL)	121.7±30.6	119.5±30.5	123.6±30.5	<0.001
FPG (mg/dL)	94 [88–101]	96 [90–105]	92 [87–98]	<0.001
eGFR (mL/min/1.73 m2)	107.0±19.4	105.8±18.9	108.0±19.7	<0.001
Current tobacco smoking	9,749 (21.2)	8,338 (38.7)	1,411 (5.8)	<0.001
Habitual alcohol drinking	11,406 (24.8)	9,548 (44.3)	1,858 (7.6)	<0.001
Habitual exercise	12,864 (28.0)	6,324 (29.3)	6,540 (26.9)	<0.001
Antidyslipidemic medication	2,914 (6.3)	998 (4.7)	1,916 (7.8)	<0.001
Antidiabetic medication	1,407 (3.1)	909 (4.2)	498 (2.0)	<0.001
5-year hypertension incidence	7,591 (16.5)	4,130 (19.2)	3,461 (14.2)	<0.001

Unless indicated otherwise, data are given as the mean±SD, median [interquartile range], or n (%). BMI, body mass index; DBP, diastolic blood pressure; eGFR, estimated glomerular filtration rate; FPG, fasting plasma glucose; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; SBP, systolic blood pressure; WC, waist circumference; WHtR, waist to height ratio.

Predictive Ability of BMI and WHtR Individually for the Risk of Hypertension

Predictive ability was based on the AUC in ROC analysis. The AUC of BMI was 0.57 in men and 0.62 in women; the AUC for WHtR was 0.60 in men and 0.64 in women. We observed a minimal difference in the predictive ability of BMI and WHtR individually in both sexes; generally, women had slightly higher AUC than men.

shows the incidence of hypertension according to high or low BMI and high or low WHtR separately. Participants were categorized as having high or low BMI and WHtR based on median values. In men, BMI ≥23.2 kg/m2 and WHtR ≥0.50 were considered high, whereas BMI <23.2 kg/m2 and WHtR <0.50 were considered low. In women, BMI ≥22.0 kg/m2 and WHtR ≥0.52 were considered high, whereas BMI <22.0 kg/m2 and WHtR <0.52 were considered low. The incidence of hypertension in men with a low BMI was 15.9%, and that in men with a low WHtR was 14.6%. These rates were lower than in men with a high BMI (22.2%) and a high WHtR (23.5%). In women, the incidence of hypertension was lower among those with a low BMI (9.8%) or a low WHtR (9.2%) than among those with a high BMI (18.4%) or a high WHtR (18.6%).

Figure 2.

Incidence of hypertension in the sexes considering body mass index (BMI) and waist to height ratio (WHtR) separately. The association between low or high BMI and WHtR separately and the 5-year incidence of hypertension in men and women was evaluated. The number of participants, the number of cases of hypertension, and the proportion of hypertension after a 5-year follow-up are shown. Analyses were performed using Chi-squared tests. In men, low and high BMI were defined as <23.2 and ≥23.2 kg/m2, respectively, whereas low and high WHtR were defined as <0.50 and ≥0.50, respectively. In women, low and high BMI were defined as <22.0 and ≥22.0 kg/m2, respectively, whereas low and high WHtR were defined as <0.52 and ≥0.52, respectively.

shows the relationship of each of the obesity indices with the risk of hypertension among men and women after 5 years of follow-up. Both high BMI and high WHtR were separately associated with an increase in the risk of hypertension in both sexes, even after full adjustments in Model 3 (high BMI: OR 1.26 [P<0.001] and 1.46 [P<0.001] in men and women, respectively; high WHtR: OR 1.31 [P<0.001] and 1.39 [P<0.001] in men and women, respectively).

Table 2.

ORs for the 5-Year Incidence of Hypertension for BMI and WHtR Separately by Sex

	Univariate		Multivariate
	OR (95% CI)	P value	Model 1		Model 2		Model 3
			OR (95% CI)	P value	OR (95% CI)	P value	OR (95% CI)	P value
Men
Low BMI	Ref.		Ref.		Ref.		Ref.
High BMI	1.51 (1.41–1.62)	<0.001	1.56 (1.45–1.67)	<0.001	1.28 (1.19–1.38)	<0.001	1.26 (1.17–1.36)	<0.001
Low WHtR	Ref.		Ref.		Ref.		Ref.
High WHtR	1.80 (1.67–1.93)	<0.001	1.63 (1.52–1.75)	<0.001	1.33 (1.23–1.43)	<0.001	1.31 (1.21–1.41)	<0.001
Women
Low BMI	Ref.		Ref.		Ref.		Ref.
High BMI	2.07 (1.92–2.23)	<0.001	1.89 (1.75–2.04)	<0.001	1.47 (1.36–1.60)	<0.001	1.46 (1.35–1.59)	<0.001
Low WHtR	Ref.		Ref.		Ref.		Ref.
High WHtR	2.25 (2.08–2.43)	<0.001	1.80 (1.65–1.94)	<0.001	1.39 (1.28–1.52)	<0.001	1.39 (1.27–1.51)	<0.001

In men, low and high BMI were defined as <23.2 and ≥23.2 kg/m2, respectively, whereas low and high WHtR were defined as <0.50 and ≥0.50, respectively. In women, low and high BMI were defined as <22.0 and ≥22.0 kg/m2, respectively, whereas low and high WHtR were defined as <0.52 and ≥0.52, respectively. The univariate and multivariate analyses were adjusted in 3 different models: Model 1, age; Model 2, age and SBP; Model 3, age, SBP, eGFR, current tobacco smoking, exercise, diabetes, and dyslipidemia. CI, confidence interval; OR, odds ratio. Other abbreviations as in Table 1.

Predictive Ability of the Combination of BMI and WHtR of the Risk of Hypertension

shows the 5-year incidence of hypertension among men and women in each of the 4 categories of BMI+WHtR combined. Participants in the low BMI+low WHtR group had the lowest incidence of hypertension in both sexes (men, 14.3%; women, 8.6%). Furthermore, in men, there was a similar incidence of hypertension in the high BMI+high WHtR (23.4%) and low BMI+high WHtR (23.9%) groups, but in women the incidence of hypertension was higher in the high BMI+high WHtR (19.5%) than low BMI+high WHtR (14.8%) group.

Figure 3.

Incidence of hypertension in the sexes according to body mass index (BMI) plus waist to height ratio (WHtR) combined. Categories of low and high BMI and WHtR were considered together to assess their association with the 5-year incidence of hypertension among men and women. The number of participants, the number of cases of hypertension, and the proportion of hypertension after a 5-year follow-up are shown. Analyses were performed using Chi-squared tests. In men, low and high BMI were defined as <23.2 and ≥23.2 kg/m2, respectively, whereas low and high WHtR were defined as <0.50 and ≥0.50, respectively. In women, low and high BMI were defined as <22.0 and ≥22.0 kg/m2, respectively, whereas low and high WHtR were defined as <0.52 and ≥0.52, respectively.

presents results of univariate and multivariate logistic regression analyses to determine the effects of the 4 categories of BMI+WHtR combined on predicting the risk of hypertension by sex (using the low BMI+low WHtR group as a reference). In women, the OR for the non-adjusted analysis revealed an increase in the risk of developing hypertension in all categories with at least 1 elevated obesity index; nevertheless, the risk was highest among the high BMI+high WHtR group (OR 2.6; 95% CI 2.38–2.83; P<0.001). Among men, the risk of developing hypertension was not increased in participants with a high BMI+low WHtR, whereas the risk of developing hypertension was increased in participants with low BMI+high WHtR or high BMI+high WHtR. In multivariate Model 1, the categories for obesity in each sex appeared to be associated with the risk of developing hypertension; women with high BMI+high WHtR had the highest risk, followed by men with high BMI+high WHtR. In Model 2, women had an increased risk of developing hypertension in all categories; however, among men, those in the high BMI+low WHtR group showed no increased risk of developing hypertension. In addition, the OR for the combined effect of BMI and WHtR in the fully adjusted model (Model 3) showed a significant increase in the risk of hypertension in all categories among women. In contrast, we found that men with a high BMI+low WHtR did not have an increased risk of developing hypertension (OR 1.14; 95% CI 0.98–1.32; P=0.08).

Table 3.

ORs for the 5-Year Incidence of Hypertension Using the Combination of BMI and WHtR by Sex

	Univariate		Multivariate
	OR (95% CI)	P value	Model 1		Model 2		Model 3
			OR (95% CI)	P value	OR (95% CI)	P value	OR (95% CI)	P value
Men
Low BMI+low WHtR	Ref.		Ref.		Ref.		Ref.
High BMI+low WHtR	1.15 (1.00–1.32)	0.050	1.35 (1.18–1.56)	<0.001	1.15 (0.99–1.33)	0.066	1.14 (0.98–1.32)	0.080
Low BMI+high WHtR	1.88 (1.67–2.13)	<0.001	1.50 (1.32–1.70)	<0.001	1.27 (1.11–1.45)	<0.001	1.26 (1.10–1.44)	<0.001
High BMI+high WHtR	1.84 (1.70–1.98)	<0.001	1.76 (1.62–1.90)	<0.001	1.38 (1.27–1.50)	<0.001	1.36 (1.25–1.48)	<0.001
Women
Low BMI+low WHtR	Ref.		Ref.		Ref.		Ref.
High BMI+low WHtR	1.53 (1.32–1.78)	<0.001	1.65 (1.42–1.93)	<0.001	1.37 (1.17–1.61)	<0.001	1.37 (1.17–1.61)	<0.001
Low BMI+high WHtR	1.86 (1.63–2.12)	<0.001	1.35 (1.18–1.55)	<0.001	1.16 (1.00–1.33)	0.043	1.15 (1.00–1.33)	0.048
High BMI+high WHtR	2.60 (2.38–2.83)	<0.001	2.13 (1.94–2.32)	<0.001	1.56 (1.42–1.71)	<0.001	1.55 (1.41–1.71)	<0.001

In men, low and high BMI were defined as <23.2 and ≥23.2 kg/m2, respectively, whereas low and high WHtR were defined as <0.50 and ≥0.50, respectively. In women, low and high BMI were defined as <22.0 and ≥22.0 kg/m2, respectively, whereas low and high WHtR were defined as <0.52 and ≥0.52, respectively. The univariate and multivariate analyses were adjusted in 3 different models: Model 1, age; Model 2, age and SBP; Model 3, age, SBP, eGFR, current tobacco smoking, exercise, diabetes, and dyslipidemia. Abbreviations as in Tables 1,2.

Discussion

This study examined the clinical significance of the combination of WHtR and BMI as a composite index for the assessment of the risk of hypertension for each sex. We observed an improvement in the prediction of the incidence of hypertension when BMI and WHtR were simultaneously accounted for compared with the use of a single index. In addition, regardless of BMI, a high WHtR, which reflects an increase in the proportion of abdominal fat, was observed to be associated with an increased risk of hypertension in both sexes. After adjusting for confounding factors, we found differences in the risk of hypertension between the 2 sexes. A high BMI determined the risk of hypertension in all women who participated in the study, but not in men who had a low WHtR.

Hypertension and obesity have a complex association. Understanding the distribution of excess adipose tissue using anthropometric tools is an elementary method that provides useful information for screening participants for cardiovascular risk. BMI has been used worldwide because of its relatively simple approach, and obesity evaluated by BMI is a well-recognized risk factor for cardiometabolic morbidity and mortality. However, BMI cannot measure body fat distribution and cannot distinguish between fat-free mass and fat mass. The different BMI cut-off points for the overweight and obesity categories can be misleading when it comes to the classification of the risk of hypertension in different ethnicities. For example, Asians are prone to developing metabolic disorders, including diabetes, dyslipidemia, and hypertension, within the normal weights and BMI values that are set according to Western standards. It has been suggested that indices such as WC, waist to hip ratio, and WHtR may predict the distribution of adiposity, cardiometabolic risk, and mortality better than BMI. However, our focus was on WHtR because some systematic reviews and meta-analyses across ethnic groups using the AUC from ROC analysis found WHtR was better and more useful for risk assessment than BMI and WC., These previous findings indicate a slightly superior ability of WHtR over BMI in predicting the risk of hypertension. Furthermore, considering the advantages of each anthropometric tool in assessing fat distribution, combining BMI and WHtR may reduce the limitations associated with the single index. In lean or healthy individuals, adipose tissue is distributed and confined to specific areas in the subcutaneous and visceral tissues for excess lipid storage. This is achieved by the adaptive mechanisms of the adipocytes to hyperplasia and hypertrophy. However, under conditions of overwhelmed capacity, excess fat begins to accumulate ectopically as visceral fat, which better predicts the risk of cardiometabolic sequelae associated with obesity than does peripheral or subcutaneous fat.

In the present study, among the groups of men and women, those with the lowest BMI and lowest WHtR were least likely to develop hypertension over the next 5 years. The study found that the combination of high BMI and low WHtR was associated with an increased risk of hypertension in women and that BMI individually contributed to the risk of hypertension. In contrast, men with a high BMI and low WHtR did not have an increased risk of developing hypertension, whereas the risk was increased in those with a high WHtR even if the BMI was low. A man with a low BMI and high WHtR would likely have an “apple-shaped body”; this would be associated with a lower BMI but a larger WC and an increase in abdominal visceral fat deposits. In this context, the findings of the present study demonstrate the value of WHtR in establishing the association between abdominal fat accumulation and an increased risk of hypertension in men, whereas in women both general and abdominal fat accumulation is associated with the risk of hypertension. Men with a high WHtR would likely be missed in the screening of hypertension incidence if BMI was the only tool used for evaluation and WHtR was not accounted for.

To the best of our knowledge, no longitudinal studies have evaluated the predictive ability of the combination of BMI and WHtR for assessing the risk of hypertension in each of the sexes in the general Japanese population. In a cross-sectional study that assessed cardiometabolic risk among middle-aged adults in Ireland, tertiles of the combination of BMI and WHtR identified consistent metabolic differences relative to those characterized based on one index, suggesting that risk stratification using a composite index is a better method to identify individuals at risk than using a single index. The results of a study examining a combination of BMI and WC were similar to those of the present study in terms of a stronger association and improved assessment of the risk of hypertension when both indices were evaluated together. That study found that men with a high BMI but normal WC had an increased risk of developing hypertension; however, in the present study, men had no increased risk of hypertension when BMI was high and WHtR was low.

The observed differences between the sexes can be explained by the fact that adipose tissue is an active endocrine organ that produces hormones, cytokines, chemokines, and growth factors; any dysregulation may lead to obesity-related metabolic disorders. This depends on the amount of extra fat accumulated and its anatomical location, which is greatly affected by sex., Regardless of ethnicity, age, or an increase in BMI, the body fat percentage in women remains higher than in men, whereas men have an increased muscle mass percentage than women. Furthermore, it has been reported that women accumulate more adipose tissue in the peripheral and lower body areas, including subcutaneous fat and gluteal–femoral fat, whereas men accumulate a great amount of visceral adipose tissue in the upper body regions., Our findings also suggest there is visceral fat accumulation among men in this population that is a determinant of hypertension risk. Men are also more prone to multiple risk factors, including tobacco smoking and stress, that may lead to dysfunctional subcutaneous adipose tissue and a gradual accumulation of visceral adipose tissue, an increase cell size, and poor buffering capacity.

The assessment of overweight and obesity using BMI alone could be insufficient because excess visceral adiposity can be found not only in obese patients, but also in those who are overweight or even have normal weight. The combination of BMI and WHtR to gauge the risk of hypertension would assist in the screening of obesity phenotypes, such as metabolically unhealthy non-obese individuals. Furthermore, when weight loss is considered for obesity control, maintaining a lower WHtR in men could be beneficial; however, in women, obesity control by maintaining a lower BMI and WHtR could be beneficial to reduce the risk of developing hypertension.

The present study has several limitations. First, we only included participants who were involved in the health checkups at a single facility in Japan and so it may not be possible to extrapolate the findings to other ethnic groups. Second, the data were not collected prospectively; we could not assess time to event because our statistical analysis was limited by most participants missing their annual checkups, leading to non-consecutive visits, and so the findings should be verified in further prospective observational studies. Third, we did not take BP readings on several occasions to assess sustained elevated BP and the reproducibility of the diagnosis of hypertension; therefore, the results need to be confirmed in other studies using multiple BP measurements. Finally, we had no information on salt intake, vegetable and fruit consumption, stress, sleep time, menopause, and sex hormones, all of which may affect BP.

In conclusion, we found that the combination of BMI and WHtR improved the prediction of the incidence of hypertension in the general Japanese population and that a high BMI determined the risk of hypertension in all women who participated in the study, but not in men who had a low WHtR. WHtR should be used simultaneously with BMI to evaluate the risk of hypertension to overcome sex differences and the limitations of using a single index in predicting the incidence of hypertension.

Sources of Funding

This study did not receive any specific funding.

Disclosures

M.O. is a member of Circulation Reports’ Editorial Team. The remaining authors have no conflicts of interest to disclose.

IRB Information

This study was approved by the Institutional Ethics Committee of the Graduate School of Medical and Dental Sciences, Kagoshima University (No. 520).