AIMS: The aim of this study was to assess the relationship between short stature and coronary heart disease (CHD) morbidity and mortality. METHODS AND RESULTS: We performed a systematic search from MEDLINE, PREMEDLINE, and All EBM Reviews as well as from a reference list of relevant articles. We used SPICO (Study design, Patient, Intervention, Control-intervention, Outcome) criteria. The methodological quality of studies was analysed by modified Borghoust criteria. From a total of 1907 articles, we selected 52 studies comprising population-based follow-up studies and patient cohorts followed after a CHD event, as well as case-control studies with height either as a continuous or categorical variable, totalling 3 012 747 individuals. The short ones were below 160.5 cm and tall ones over 173.9 cm on average. Among the shortest height category, the relative risks were 1.35 (95% CI 1.25-1.44) for all-cause mortality, 1.55 (1.37-1.74) for all cardiovascular disease (CVD) mortality, 1.49 (1.33-1.67) for CHD, and 1.52 (1.28-1.81) for myocardial infarction when compared with those within the highest height category. The mean relative risk was 1.46 (1.37-1.55). Short stature was associated with increased cardiovascular morbidity and mortality in both genders. CONCLUSION: The relationship between short stature and CVD appears to be a real one. On the basis of comparison, adults within the shortest category had an approximately 50% higher risk of CHD morbidity and mortality than tall individuals.
AIMS: The aim of this study was to assess the relationship between short stature and coronary heart disease (CHD) morbidity and mortality. METHODS AND RESULTS: We performed a systematic search from MEDLINE, PREMEDLINE, and All EBM Reviews as well as from a reference list of relevant articles. We used SPICO (Study design, Patient, Intervention, Control-intervention, Outcome) criteria. The methodological quality of studies was analysed by modified Borghoust criteria. From a total of 1907 articles, we selected 52 studies comprising population-based follow-up studies and patient cohorts followed after a CHD event, as well as case-control studies with height either as a continuous or categorical variable, totalling 3 012 747 individuals. The short ones were below 160.5 cm and tall ones over 173.9 cm on average. Among the shortest height category, the relative risks were 1.35 (95% CI 1.25-1.44) for all-cause mortality, 1.55 (1.37-1.74) for all cardiovascular disease (CVD) mortality, 1.49 (1.33-1.67) for CHD, and 1.52 (1.28-1.81) for myocardial infarction when compared with those within the highest height category. The mean relative risk was 1.46 (1.37-1.55). Short stature was associated with increased cardiovascular morbidity and mortality in both genders. CONCLUSION: The relationship between short stature and CVD appears to be a real one. On the basis of comparison, adults within the shortest category had an approximately 50% higher risk of CHD morbidity and mortality than tall individuals.
Authors: Andrea E Cassidy-Bushrow; Lawrence F Bielak; Patrick F Sheedy; Stephen T Turner; Julia S Chu; Patricia A Peyser Journal: Atherosclerosis Date: 2011-08-30 Impact factor: 5.162
Authors: Ju-Hyun Park; Mitchell H Gail; Clarice R Weinberg; Raymond J Carroll; Charles C Chung; Zhaoming Wang; Stephen J Chanock; Joseph F Fraumeni; Nilanjan Chatterjee Journal: Proc Natl Acad Sci U S A Date: 2011-10-14 Impact factor: 11.205
Authors: Tamar Sofer; Jee-Young Moon; Carmen R Isasi; Qibin Qi; Neomi A Shah; Robert C Kaplan; Mark H Kuniholm Journal: Int J Epidemiol Date: 2018-12-01 Impact factor: 7.196
Authors: Michael A Rosenberg; Faye L Lopez; Petra Bůžková; Selcuk Adabag; Lin Y Chen; Nona Sotoodehnia; Richard A Kronmal; David S Siscovick; Alvaro Alonso; Alfred Buxton; Aaron R Folsom; Kenneth J Mukamal Journal: Ann Epidemiol Date: 2013-11-26 Impact factor: 3.797