Malik J1, Novakova L2, Valerianova A3, Chytilova E3, Lejsek V3, Buryskova Salajova K3, Lambert L4, Grus T5, Porizka M6, Michalek P6. 1. Third Department of Internal Medicine, General University Hospital, First Faculty of Medicine, Charles University, Prague, Czech Republic. jan.malik@vfn.cz. 2. Faculty of Mechanical Engineering, Jan Evangelista Purkyne University, Usti nad Labem, Czech Republic. 3. Third Department of Internal Medicine, General University Hospital, First Faculty of Medicine, Charles University, Prague, Czech Republic. 4. Department of Radiology, General University Hospital, First Faculty of Medicine, Charles University, Prague, Czech Republic. 5. Second Department of Surgery, Department of Cardiovascular Surgery, General University Hospital, First Faculty of Medicine, Charles University, Prague, Czech Republic. 6. Department of Anesthesiology, Resuscitation and Intensive Medicine, General University Hospital, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Abstract
PURPOSE OF REVIEW: Wall shear stress describes the mechanical influence of blood flow on the arterial wall. In this review, we discuss the role of the wall shear stress in the development of atherosclerosis and its complications. RECENT FINDINGS: Areas with chronically low, oscillating wall shear stress are most prone to plaque development and include outer bifurcation walls and inner walls of arches. In some diseases, patients have lower wall shear stress even in straight arterial segments; also, these findings were associated with atherosclerosis. High wall shear stress develops in the distal part (shoulder) of a stenosis and contributes to plaque destabilization. Wall shear stress changes are involved in the development of atherosclerosis. They are not fully understood yet and act in concert with tangential wall stress.
PURPOSE OF REVIEW: Wall shear stress describes the mechanical influence of blood flow on the arterial wall. In this review, we discuss the role of the wall shear stress in the development of atherosclerosis and its complications. RECENT FINDINGS: Areas with chronically low, oscillating wall shear stress are most prone to plaque development and include outer bifurcation walls and inner walls of arches. In some diseases, patients have lower wall shear stress even in straight arterial segments; also, these findings were associated with atherosclerosis. High wall shear stress develops in the distal part (shoulder) of a stenosis and contributes to plaque destabilization. Wall shear stress changes are involved in the development of atherosclerosis. They are not fully understood yet and act in concert with tangential wall stress.
Authors: Claudio A Franco; Martin L Jones; Miguel O Bernabeu; Ilse Geudens; Thomas Mathivet; Andre Rosa; Felicia M Lopes; Aida P Lima; Anan Ragab; Russell T Collins; Li-Kun Phng; Peter V Coveney; Holger Gerhardt Journal: PLoS Biol Date: 2015-04-17 Impact factor: 8.029
Authors: Howard H Carter; Ceri L Atkinson; Ilkka H A Heinonen; Andrew Haynes; Elisa Robey; Kurt J Smith; Philip N Ainslie; Ryan L Hoiland; Daniel J Green Journal: Hypertension Date: 2016-08-29 Impact factor: 10.190