Golnoosh Goodarzi1, Hadis Mozaffari2, Tahereh Raeisi3, Fatemeh Mehravar4, Bahman Razi5, Maryam Lafzi Ghazi6, Nazila Garousi7, Shahab Alizadeh8, Parisa Janmohammadi9. 1. Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran. 2. Faculty of Land and Food Systems, University of British Columbia, Vancouver, Canada. 3. Department of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran. 4. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences (TUMS), Tehran, Iran. 5. Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. 6. Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran. 7. Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran. 8. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Tehran Province, Iran. 9. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Tehran Province, Iran. p-janmohammadi@alumnus.tums.ac.ir.
Abstract
BACKGROUND: The association of obesity with colorectal cancer (CRC) may vary depending on metabolic status. OBJECTIVE: This meta-analysis aimed to investigate the combined impacts of obesity and metabolic status on CRC risk. METHODS: The Scopus, PubMed, and web of sciences databases were systematically searched up to Jun 2021 to find all eligible publications examining CRC risk in individuals with metabolically unhealthy normal-weight (MUHNW), metabolically healthy obesity (MHO), and metabolically unhealthy obesity (MUHO) phenotypes. RESULTS: A total of 7 cohort studies with a total of 759,066 participants were included in this meta-analysis. Compared with healthy normal-weight people, MUHNW, MHO, and MUHO individuals indicated an increased risk for CRC with a pooled odds ratio of 1.19 (95% CI = 1.09-1.31) in MUHNW, 1.14 (95% CI = 1.06-1.22) in MHO, and 1.24 (95% CI = 1.19-1.29) in MUHO subjects. When analyses were stratified based on gender, associations remained significant for males. However, the elevated risk of CRC associated with MHO and MUHO was not significant in female participants. CONCLUSIONS: The individuals with metabolic abnormality, although at a normal weight, have an increased risk for CRC. Moreover, obesity is associated with CRC irrespective of metabolic status.
BACKGROUND: The association of obesity with colorectal cancer (CRC) may vary depending on metabolic status. OBJECTIVE: This meta-analysis aimed to investigate the combined impacts of obesity and metabolic status on CRC risk. METHODS: The Scopus, PubMed, and web of sciences databases were systematically searched up to Jun 2021 to find all eligible publications examining CRC risk in individuals with metabolically unhealthy normal-weight (MUHNW), metabolically healthy obesity (MHO), and metabolically unhealthy obesity (MUHO) phenotypes. RESULTS: A total of 7 cohort studies with a total of 759,066 participants were included in this meta-analysis. Compared with healthy normal-weight people, MUHNW, MHO, and MUHO individuals indicated an increased risk for CRC with a pooled odds ratio of 1.19 (95% CI = 1.09-1.31) in MUHNW, 1.14 (95% CI = 1.06-1.22) in MHO, and 1.24 (95% CI = 1.19-1.29) in MUHO subjects. When analyses were stratified based on gender, associations remained significant for males. However, the elevated risk of CRC associated with MHO and MUHO was not significant in female participants. CONCLUSIONS: The individuals with metabolic abnormality, although at a normal weight, have an increased risk for CRC. Moreover, obesity is associated with CRC irrespective of metabolic status.
Authors: Carlos A Aguilar-Salinas; Eduardo García García; Lorena Robles; Daniela Riaño; Doris Georgina Ruiz-Gomez; Ana Cristina García-Ulloa; Marco A Melgarejo; Margarita Zamora; Luz E Guillen-Pineda; Roopa Mehta; Samuel Canizales-Quinteros; Ma Teresa Tusie Luna; Francisco J Gómez-Pérez Journal: J Clin Endocrinol Metab Date: 2008-08-05 Impact factor: 5.958
Authors: Joshua A Bell; Mark Hamer; Séverine Sabia; Archana Singh-Manoux; G David Batty; Mika Kivimaki Journal: J Am Coll Cardiol Date: 2015-01-06 Impact factor: 24.094