Seong-Geun Moon1, Boyoung Park1. 1. Department of Preventive Medicine, Hanyang University College of Medicine, Seoul, Korea.
Abstract
OBJECTIVES: This study aimed to determine the association between metabolic syndrome (MetS) and the incidence of colorectal cancer (CRC) in Korean women with obesity. METHODS: Cancer-free women (n=6 142 486) aged 40-79 years, who underwent National Health Insurance Service health examinations in 2009 and 2010 were included. The incidence of CRC was followed until 2018. The hazard ratio (HR) of MetS for the incidence of colon and rectal cancer was analyzed according to body mass index (BMI) categories, adjusting for confounders such as women's reproductive factors. In addition, the heterogeneity of associations across BMI categories was assessed. RESULTS: Women with MetS were at increased risk of colon and rectal cancer compared to women without MetS (HR, 1.20; 95% confidence interval [CI], 1.16 to 1.23 and HR,1.15; 95% CI, 1.11 to 1.20), respectively. The HR of MetS for colon cancer across BMI categories was 1.12 (95% CI, 1.06 to 1.19), 1.14 (95% CI, 1.08 to 1.20), and 1.16 (95% CI, 1.12 to 1.21) in women with BMIs <23.0 kg/m2, 23.0-24.9 kg/m2, and ≥25.0 kg/m2, respectively. The HR of MetS for rectal cancer across corresponding BMI categories was 1.16 (95% CI, 1.06 to 1.26), 1.14 (95% CI, 1.05 to 1.23), and 1.13 (95% CI, 1.06 to 1.20). The heterogeneity of associations across BMI categories was not significant in either colon or rectal cancer (p=0.587 for colon cancer and p=0.927 for rectal cancer). CONCLUSIONS: Women with MetS were at increased risk of colon and rectal cancer. Clinical and public health strategies should be considered for primary CRC prevention with an emphasis on improving women's metabolic health across all BMI groups.
OBJECTIVES: This study aimed to determine the association between metabolic syndrome (MetS) and the incidence of colorectal cancer (CRC) in Korean women with obesity. METHODS: Cancer-free women (n=6 142 486) aged 40-79 years, who underwent National Health Insurance Service health examinations in 2009 and 2010 were included. The incidence of CRC was followed until 2018. The hazard ratio (HR) of MetS for the incidence of colon and rectal cancer was analyzed according to body mass index (BMI) categories, adjusting for confounders such as women's reproductive factors. In addition, the heterogeneity of associations across BMI categories was assessed. RESULTS: Women with MetS were at increased risk of colon and rectal cancer compared to women without MetS (HR, 1.20; 95% confidence interval [CI], 1.16 to 1.23 and HR,1.15; 95% CI, 1.11 to 1.20), respectively. The HR of MetS for colon cancer across BMI categories was 1.12 (95% CI, 1.06 to 1.19), 1.14 (95% CI, 1.08 to 1.20), and 1.16 (95% CI, 1.12 to 1.21) in women with BMIs <23.0 kg/m2, 23.0-24.9 kg/m2, and ≥25.0 kg/m2, respectively. The HR of MetS for rectal cancer across corresponding BMI categories was 1.16 (95% CI, 1.06 to 1.26), 1.14 (95% CI, 1.05 to 1.23), and 1.13 (95% CI, 1.06 to 1.20). The heterogeneity of associations across BMI categories was not significant in either colon or rectal cancer (p=0.587 for colon cancer and p=0.927 for rectal cancer). CONCLUSIONS: Women with MetS were at increased risk of colon and rectal cancer. Clinical and public health strategies should be considered for primary CRC prevention with an emphasis on improving women's metabolic health across all BMI groups.
Entities:
Keywords:
Body mass index; Colorectal neoplasms; Metabolic syndrome
Authors: Gwen Murphy; Susan S Devesa; Amanda J Cross; Peter D Inskip; Katherine A McGlynn; Michael B Cook Journal: Int J Cancer Date: 2010-05-25 Impact factor: 7.396
Authors: Scott M Grundy; James I Cleeman; Stephen R Daniels; Karen A Donato; Robert H Eckel; Barry A Franklin; David J Gordon; Ronald M Krauss; Peter J Savage; Sidney C Smith; John A Spertus; Fernando Costa Journal: Cardiol Rev Date: 2005 Nov-Dec Impact factor: 2.644
Authors: Neil Murphy; Robert Carreras-Torres; Mingyang Song; Andrew T Chan; Richard M Martin; Nikos Papadimitriou; Niki Dimou; Konstantinos K Tsilidis; Barbara Banbury; Kathryn E Bradbury; Jelena Besevic; Sabina Rinaldi; Elio Riboli; Amanda J Cross; Ruth C Travis; Claudia Agnoli; Demetrius Albanes; Sonja I Berndt; Stéphane Bézieau; D Timothy Bishop; Hermann Brenner; Daniel D Buchanan; N Charlotte Onland-Moret; Andrea Burnett-Hartman; Peter T Campbell; Graham Casey; Sergi Castellví-Bel; Jenny Chang-Claude; María-Dolores Chirlaque; Albert de la Chapelle; Dallas English; Jane C Figueiredo; Steven J Gallinger; Graham G Giles; Stephen B Gruber; Andrea Gsur; Jochen Hampe; Heather Hampel; Tabitha A Harrison; Michael Hoffmeister; Li Hsu; Wen-Yi Huang; Jeroen R Huyghe; Mark A Jenkins; Temitope O Keku; Tilman Kühn; Sun-Seog Kweon; Loic Le Marchand; Christopher I Li; Li Li; Annika Lindblom; Vicente Martín; Roger L Milne; Victor Moreno; Polly A Newcomb; Kenneth Offit; Shuji Ogino; Jennifer Ose; Vittorio Perduca; Amanda I Phipps; Elizabeth A Platz; John D Potter; Conghui Qu; Gad Rennert; Lori C Sakoda; Clemens Schafmayer; Robert E Schoen; Martha L Slattery; Catherine M Tangen; Cornelia M Ulrich; Franzel J B van Duijnhoven; Bethany Van Guelpen; Kala Visvanathan; Pavel Vodicka; Ludmila Vodickova; Veronika Vymetalkova; Hansong Wang; Emily White; Alicja Wolk; Michael O Woods; Anna H Wu; Wei Zheng; Ulrike Peters; Marc J Gunter Journal: Gastroenterology Date: 2019-12-27 Impact factor: 22.682