Brianna Croft1, Melissa Reed1, Caitlyn Patrick1, Natalie Kovacevich1, Ioannis A Voutsadakis2,3. 1. Clinical Trials Unit, Sault Area Hospital, Sault Ste Marie, Ontario, Canada. 2. Algoma District Cancer Program, Sault Area Hospital, Sault Ste Marie, Ontario, P6B 0A8, Canada. ivoutsadakis@yahoo.com. 3. Division of Clinical Sciences, Northern Ontario School of Medicine, Sudbury, Ontario, Canada. ivoutsadakis@yahoo.com.
Abstract
BACKGROUND: Attempts to introduce prognostic factors for survival outcomes in localized colorectal cancer patients receiving surgical treatment with or without adjuvant therapies, beyond the classic staging parameters, have been met with limited success. Obesity and diabetes mellitus are among the conditions that predispose to colorectal cancer but their value as prognostic markers once the disease is diagnosed is controversial. PATIENTS AND METHODS: This study examines the prognostic value of the components of metabolic syndrome in a retrospective series of colorectal cancer patients with stages I to III disease followed in a single center. RESULTS: Among the four components of the metabolic syndrome, only diabetes was independently associated with progression-free survival (PFS) while obesity, hypertension, and dyslipidemia were not. No associations of the metabolic syndrome (MS) or its components with overall survival (OS) were observed in multivariate analysis. CONCLUSION: These data pinpoint to diabetes mellitus (DM) as a possible prognostic factor for PFS in localized colorectal cancer and further cast doubt for the value of obesity as measured by body mass index (BMI) on local stage colorectal cancer prognosis.
BACKGROUND: Attempts to introduce prognostic factors for survival outcomes in localized colorectal cancerpatients receiving surgical treatment with or without adjuvant therapies, beyond the classic staging parameters, have been met with limited success. Obesity and diabetes mellitus are among the conditions that predispose to colorectal cancer but their value as prognostic markers once the disease is diagnosed is controversial. PATIENTS AND METHODS: This study examines the prognostic value of the components of metabolic syndrome in a retrospective series of colorectal cancerpatients with stages I to III disease followed in a single center. RESULTS: Among the four components of the metabolic syndrome, only diabetes was independently associated with progression-free survival (PFS) while obesity, hypertension, and dyslipidemia were not. No associations of the metabolic syndrome (MS) or its components with overall survival (OS) were observed in multivariate analysis. CONCLUSION: These data pinpoint to diabetes mellitus (DM) as a possible prognostic factor for PFS in localized colorectal cancer and further cast doubt for the value of obesity as measured by body mass index (BMI) on local stage colorectal cancer prognosis.
Authors: Denalee M O'Malley; Cindy K Blair; Alissa Greenbaum; Charles L Wiggins; Ashwani Rajput; Vi K Chiu; Anita Y Kinney Journal: J Community Genet Date: 2022-01-08
Authors: Laura Del Puerto-Nevado; Pablo Minguez; Marta Corton; Sonia Solanes-Casado; Isabel Prieto; Sebastian Mas; Ana Belen Sanz; Paula Gonzalez-Alonso; Cristina Villaverde; Sergio Portal-Nuñez; Oscar Aguilera; Carmen Gomez-Guerrero; Pedro Esbrit; Fernando Vivanco; Nieves Gonzalez; Carmen Ayuso; Alberto Ortiz; Federico Rojo; Jesus Egido; Gloria Alvarez-Llamas; Jesus Garcia-Foncillas Journal: Mol Oncol Date: 2019-02-16 Impact factor: 6.603