Literature DB >> 3500515

Three-dimensional structure of interleukin-2.

B J Brandhuber1, T Boone, W C Kenney, D B McKay.   

Abstract

Interleukin-2 is an effector protein that participates in modulating the immune response; it has become a focal point for the study of lymphokine structure and function. The three-dimensional structure of the interleukin molecule has been solved to 3.0 angstrom resolution. Interleukin-2 has a novel alpha-helical tertiary structure that suggests one portion of the molecule forms a structural scaffold, which underlies the receptor binding facets of the molecule.

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Year:  1987        PMID： 3500515     DOI： 10.1126/science.3500515

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  42 in total

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2.  Interleukin-2 receptor gene polymorphism in Chinese patients with systemic lupus erythematosus.

Authors:  Chang-Hai Tsai; Chung-Ming Huang; Sui-Foon Lo; Lei Wan; Fuu-Jen Tsai
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3.  Utilizing IL-12, IL-15 and IL-7 as Mucosal Vaccine Adjuvants.

Authors:  Liljana Stevceva; Marcin Moniuszko; Maria Grazia Ferrari
Journal:  Lett Drug Des Discov       Date:  2006       Impact factor: 1.150

4.  Sorting the chaff from the wheat at the PDB.

Authors:  Dale E Tronrud; Brian W Matthews
Journal:  Protein Sci       Date:  2009-01       Impact factor: 6.725

5.  Irreversible inactivation of interleukin 2 in a pump-based delivery environment.

Authors:  S T Tzannis; W J Hrushesky; P A Wood; T M Przybycien
Journal:  Proc Natl Acad Sci U S A       Date:  1996-05-28       Impact factor: 11.205

6.  Interleukin-2 lengthens extrajunctional acetylcholine receptor channel open time in mammalian muscle cells.

Authors:  P Lorenzon; F Ruzzier; C G Caratsch; A Giovannelli; F Velotti; A Santoni; F Eusebi
Journal:  Pflugers Arch       Date:  1991-10       Impact factor: 3.657

7.  NMR characterization of interleukin-2 in complexes with the IL-2Ralpha receptor component, and with low molecular weight compounds that inhibit the IL-2/IL-Ralpha interaction.

Authors:  S Donald Emerson; Robert Palermo; Chao-Min Liu; Jefferson W Tilley; Li Chen; Waleed Danho; Vincent S Madison; David N Greeley; Grace Ju; David C Fry
Journal:  Protein Sci       Date:  2003-04       Impact factor: 6.725

8.  Identification of a direct interaction between interleukin 2 and the p64 interleukin 2 receptor gamma chain.

Authors:  S D Voss; T P Leary; P M Sondel; R J Robb
Journal:  Proc Natl Acad Sci U S A       Date:  1993-03-15       Impact factor: 11.205

9.  Homology model of human interferon-alpha 8 and its receptor complex.

Authors:  M H Seto; R N Harkins; M Adler; M Whitlow; W B Church; E Croze
Journal:  Protein Sci       Date:  1995-04       Impact factor: 6.725

10.  Hematopoietic cytokines: similarities and differences in the structures, with implications for receptor binding.

Authors:  A Wlodawer; A Pavlovsky; A Gustchina
Journal:  Protein Sci       Date:  1993-09       Impact factor: 6.725
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