Literature DB >> 2784570

Tumor necrosis factor alpha induces expression of human immunodeficiency virus in a chronically infected T-cell clone.

T M Folks1, K A Clouse, J Justement, A Rabson, E Duh, J H Kehrl, A S Fauci.   

Abstract

Tumor necrosis factor alpha (TNF-alpha), also known as cachectin, was demonstrated to induce the expression of human immunodeficiency virus (HIV) in a chronically infected T-cell clone (ACH-2). Concentrations of recombinant TNF-alpha as low as 50 pg/ml induced a significant increase over background of HIV expression in the ACH-2 cells as determined by supernatant reverse transcriptase activity. The HIV-inducing effects of TNF-alpha could not be explained by toxic effects on the cells. In addition, both the uninfected parental cell line (A3.01) and the infected ACH-2 cells were shown to have high-affinity receptors for TNF-alpha. Transient-transfection experiments demonstrated that the inductive effects of TNF-alpha were due to specific activation of the HIV long terminal repeat. These studies provide evidence that TNF-alpha may play a role in the mechanisms of pathogenesis of HIV infection.

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Year:  1989        PMID： 2784570      PMCID： PMC286913          DOI： 10.1073/pnas.86.7.2365

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  34 in total

1.  Herpes simplex virus type-1 can reactivate transcription of latent human immunodeficiency virus.

Authors:  J D Mosca; D P Bednarik; N B Raj; C A Rosen; J G Sodroski; W A Haseltine; P M Pitha
Journal:  Nature       Date:  1987 Jan 1-7       Impact factor: 49.962

2.  Amplification of HTLV-III/LAV infection by antigen-induced activation of T cells and direct suppression by virus of lymphocyte blastogenic responses.

Authors:  J B Margolick; D J Volkman; T M Folks; A S Fauci
Journal:  J Immunol       Date:  1987-03-15       Impact factor: 5.422

3.  An endotoxin-induced serum factor that causes necrosis of tumors.

Authors:  E A Carswell; L J Old; R L Kassel; S Green; N Fiore; B Williamson
Journal:  Proc Natl Acad Sci U S A       Date:  1975-09       Impact factor: 11.205

4.  Ligand: a versatile computerized approach for characterization of ligand-binding systems.

Authors:  P J Munson; D Rodbard
Journal:  Anal Biochem       Date:  1980-09-01       Impact factor: 3.365

5.  Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin.

Authors:  D Pennica; G E Nedwin; J S Hayflick; P H Seeburg; R Derynck; M A Palladino; W J Kohr; B B Aggarwal; D V Goeddel
Journal:  Nature       Date:  1984 Dec 20-1985 Jan 2       Impact factor: 49.962

6.  Hypertriglyceridemia associated with Trypanosoma brucei brucei infection in rabbits: role of defective triglyceride removal.

Authors:  C A Rouzer; A Cerami
Journal:  Mol Biochem Parasitol       Date:  1980-10       Impact factor: 1.759

7.  Inhibition of nonspecific tumoricidal activity by activated macrophages with antiserum against a soluble cytotoxic factor.

Authors:  D N Männel; W Falk; M S Meltzer
Journal:  Infect Immun       Date:  1981-07       Impact factor: 3.441

8.  Trans-activation of the human immunodeficiency virus long terminal repeat sequence by DNA viruses.

Authors:  H E Gendelman; W Phelps; L Feigenbaum; J M Ostrove; A Adachi; P M Howley; G Khoury; H S Ginsberg; M A Martin
Journal:  Proc Natl Acad Sci U S A       Date:  1986-12       Impact factor: 11.205

9.  Independent regulation of tumor necrosis factor and lymphotoxin production by human peripheral blood lymphocytes.

Authors:  M C Cuturi; M Murphy; M P Costa-Giomi; R Weinmann; B Perussia; G Trinchieri
Journal:  J Exp Med       Date:  1987-06-01       Impact factor: 14.307

10.  Studies of endotoxin-induced decrease in lipoprotein lipase activity.

Authors:  M Kawakami; A Cerami
Journal:  J Exp Med       Date:  1981-09-01       Impact factor: 14.307
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  288 in total

1.  Reservoirs for HIV-1.

Authors: 
Journal:  Curr Infect Dis Rep       Date:  1999-08       Impact factor: 3.725

Review 2.  African enigma: key player in human immunodeficiency virus pathogenesis in developing countries?

Authors:  M Clerici; S Declich; G Rizzardini
Journal:  Clin Diagn Lab Immunol       Date:  2001-09

3.  Identification of T cell-signaling pathways that stimulate latent HIV in primary cells.

Authors:  David G Brooks; Philip A Arlen; Lianying Gao; Christina M R Kitchen; Jerome A Zack
Journal:  Proc Natl Acad Sci U S A       Date:  2003-10-20       Impact factor: 11.205

Review 4.  Antiretroviral therapy: strategies beyond single-agent reverse transcriptase inhibition.

Authors:  K J Connolly; S M Hammer
Journal:  Antimicrob Agents Chemother       Date:  1992-03       Impact factor: 5.191

5.  Kinase control prevents HIV-1 reactivation in spite of high levels of induced NF-κB activity.

Authors:  Frank Wolschendorf; Alberto Bosque; Takao Shishido; Alexandra Duverger; Jennifer Jones; Vicente Planelles; Olaf Kutsch
Journal:  J Virol       Date:  2012-02-15       Impact factor: 5.103

6.  Hepatic expression of tumour necrosis factor-alpha in chronic hepatitis B virus infection.

Authors:  M J Hussain; J Y Lau; R Williams; D Vergani
Journal:  J Clin Pathol       Date:  1994-12       Impact factor: 3.411

7.  Rational design of drugs that induce human immunodeficiency virus replication.

Authors:  Dean H Hamer; Sven Bocklandt; Louise McHugh; Tae-Wook Chun; Peter M Blumberg; Dina M Sigano; Victor E Marquez
Journal:  J Virol       Date:  2003-10       Impact factor: 5.103

8.  The -1030/-862-linked TNF promoter single-nucleotide polymorphisms are associated with the inability to control HIV-1 viremia.

Authors:  Julio C Delgado; Jessica Y Leung; Andres Baena; Olga P Clavijo; Eric Vittinghoff; Susan Buchbinder; Steven Wolinsky; Marilynn Addo; Bruce D Walker; Edmond J Yunis; Anne E Goldfeld
Journal:  Immunogenetics       Date:  2003-09-27       Impact factor: 2.846

9.  Activation of human immunodeficiency virus type 1 in monocytoid cells by the protozoan parasite Leishmania donovani.

Authors:  R Bernier; S J Turco; M Olivier; M Tremblay
Journal:  J Virol       Date:  1995-11       Impact factor: 5.103

10.  Soluble tumor necrosis factor receptor: inhibition of human immunodeficiency virus activation.

Authors:  O M Howard; K A Clouse; C Smith; R G Goodwin; W L Farrar
Journal:  Proc Natl Acad Sci U S A       Date:  1993-03-15       Impact factor: 11.205
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