Literature DB >> 3500041

Human CSF-1: gene structure and alternative splicing of mRNA precursors.

M B Ladner1, G A Martin, J A Noble, D M Nikoloff, R Tal, E S Kawasaki, T J White.   

Abstract

Bone marrow progenitor cells differentiate into mononuclear phagocytes in the presence of colony stimulating factor-1 (CSF-1). Characterization of the human CSF-1 gene shows that it contains 10 exons and 9 introns, which span 20 kb. Analysis of multiple CSF-1 transcripts demonstrates that alternate use of exon 6 splice acceptor sites and 3' noncoding sequence exons occurs. These alternatively spliced transcripts can encode either a 224 or a 522 amino acid CSF-1. Implications of differential splicing for the production and function of CSF-1 are discussed.

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Year:  1987        PMID： 3500041      PMCID： PMC553691          DOI： 10.1002/j.1460-2075.1987.tb02561.x

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  30 in total

1.  RNA molecular weight determinations by gel electrophoresis under denaturing conditions, a critical reexamination.

Authors:  H Lehrach; D Diamond; J M Wozney; H Boedtker
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Review 2.  Organization and expression of eucaryotic split genes coding for proteins.

Authors:  R Breathnach; P Chambon
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3.  A catalogue of splice junction sequences.

Authors:  S M Mount
Journal:  Nucleic Acids Res       Date:  1982-01-22       Impact factor: 16.971

4.  The isolation of structural genes from libraries of eucaryotic DNA.

Authors:  T Maniatis; R C Hardison; E Lacy; J Lauer; C O'Connell; D Quon; G K Sim; A Efstratiadis
Journal:  Cell       Date:  1978-10       Impact factor: 41.582

5.  High efficiency polyoma DNA transfection of chloroquine treated cells.

Authors:  H Luthman; G Magnusson
Journal:  Nucleic Acids Res       Date:  1983-03-11       Impact factor: 16.971

6.  Human colony-stimulating factor (CSF-1) radioimmunoassay: resolution of three subclasses of human colony-stimulating factors.

Authors:  S K Das; E R Stanley; L J Guilbert; L W Forman
Journal:  Blood       Date:  1981-09       Impact factor: 22.113

7.  Structure-function studies of a colony stimulating factor (CSF-1).

Authors:  S K Das; E R Stanley
Journal:  J Biol Chem       Date:  1982-11-25       Impact factor: 5.157

8.  Efficient infection of monkey cells with DNA of simian virus 40.

Authors:  L M Sompayrac; K J Danna
Journal:  Proc Natl Acad Sci U S A       Date:  1981-12       Impact factor: 11.205

9.  Expression of the macrophage specific colony-stimulating factor (CSF-1) during human monocytic differentiation.

Authors:  J Horiguchi; M K Warren; P Ralph; D Kufe
Journal:  Biochem Biophys Res Commun       Date:  1986-12-30       Impact factor: 3.575

10.  Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.

Authors:  J M Chirgwin; A E Przybyla; R J MacDonald; W J Rutter
Journal:  Biochemistry       Date:  1979-11-27       Impact factor: 3.162
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  37 in total

1.  Role of macrophage colony-stimulating factor in atherosclerosis: studies of osteopetrotic mice.

Authors:  J H Qiao; J Tripathi; N K Mishra; Y Cai; S Tripathi; X P Wang; S Imes; M C Fishbein; S K Clinton; P Libby; A J Lusis; T B Rajavashisth
Journal:  Am J Pathol       Date:  1997-05       Impact factor: 4.307

2.  Differential expression and processing of two cell associated forms of the kit-ligand: KL-1 and KL-2.

Authors:  E J Huang; K H Nocka; J Buck; P Besmer
Journal:  Mol Biol Cell       Date:  1992-03       Impact factor: 4.138

Review 3.  Polypeptides controlling hematopoietic cell development and activation. I. In vitro results.

Authors:  F Herrmann; R Mertelsmann
Journal:  Blut       Date:  1989-03

4.  T-cell mitogenesis stimulates the synthesis of a mRNA species coding for a 43-kDa peptide reactive with CM-H-9, a monoclonal antibody specific for placental isoferritin.

Authors:  C Moroz; N Shterman; B Kupfer; I Ginzburg
Journal:  Proc Natl Acad Sci U S A       Date:  1989-05       Impact factor: 11.205

5.  The human macrophage colony-stimulating factor gene is localized at chromosome 1 band p21 and not at 5q33.1.

Authors:  J E Landegent; P M Kluck; M W Bolk; R Willemze
Journal:  Ann Hematol       Date:  1992-02       Impact factor: 3.673

6.  Localization of a gene for autosomal dominant osteopetrosis (Albers-Schönberg disease) to chromosome 1p21.

Authors:  W Van Hul; J Bollerslev; J Gram; E Van Hul; W Wuyts; O Benichou; F Vanhoenacker; P J Willems
Journal:  Am J Hum Genet       Date:  1997-08       Impact factor: 11.025

7.  Recombinant interleukin-1 alpha, interleukin-2 and M-CSF-1 enhance the survival of newborn C57BL/6 mice inoculated intraperitoneally with a lethal dose of herpes simplex virus-1.

Authors:  C Berkowitz; Y Becker
Journal:  Arch Virol       Date:  1992       Impact factor: 2.574

8.  Differential processing of colony-stimulating factor 1 precursors encoded by two human cDNAs.

Authors:  C W Rettenmier; M F Roussel
Journal:  Mol Cell Biol       Date:  1988-11       Impact factor: 4.272

9.  Integration of the BALB/c ecotropic provirus into the colony-stimulating factor-1 growth factor locus in a myc retrovirus-induced murine monocyte tumor.

Authors:  W R Baumbach; E M Colston; M D Cole
Journal:  J Virol       Date:  1988-09       Impact factor: 5.103

10.  Human recombinant macrophage colony-stimulating factor (M-CSF) increases Cl-esterase inhibitor (Cl-INH) synthesis by human monocytes.

Authors:  B Schmidt; G Gyapay; M Válay; G Füst
Journal:  Immunology       Date:  1991-12       Impact factor: 7.397
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