Literature DB >> 3499862

Increased susceptibility to cephamycin-type antibiotics of methicillin-resistant Staphylococcus aureus defective in penicillin-binding protein 2.

K Murakami1, K Nomura, M Doi, T Yoshida.   

Abstract

A methicillin-resistant strain of Staphylococcus aureus which produced low-affinity penicillin-binding protein 2' (PBP 2') spontaneously lost PBP 2 when the strain was cultivated at 43 degrees C overnight. At 37 degrees C, the mutant had increased susceptibility to cephamycin-type beta-lactams, which showed high affinity for PBP 4. This result suggests that inhibition of PBP 4, in addition to that of PBP 2, is necessary to kill methicillin-resistant strains.

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Year:  1987        PMID： 3499862      PMCID： PMC174954          DOI： 10.1128/AAC.31.9.1423

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

1.  THE EFFECT OF GROWTH AT ELEVATED TEMPERATURES ON SOME HERITABLE PROPERTIES OF STAPHYLOCOCCUS AUREUS.

Authors:  J W MAY; R H HOUGHTON; C J PERRET
Journal:  J Gen Microbiol       Date:  1964-11

Review 2.  Interaction of penicillin with the bacterial cell: penicillin-binding proteins and penicillin-sensitive enzymes.

Authors:  P M Blumberg; J L Strominger
Journal:  Bacteriol Rev       Date:  1974-09

3.  Regulation of penicillin-binding protein activity: description of a methicillin-inducible penicillin-binding protein in Staphylococcus aureus.

Authors:  L Rossi; E Tonin; Y R Cheng; R Fontana
Journal:  Antimicrob Agents Chemother       Date:  1985-05       Impact factor: 5.191

4.  Production of low-affinity penicillin-binding protein by low- and high-resistance groups of methicillin-resistant Staphylococcus aureus.

Authors:  K Murakami; K Nomura; M Doi; T Yoshida
Journal:  Antimicrob Agents Chemother       Date:  1987-09       Impact factor: 5.191

5.  Low-affinity penicillin-binding protein associated with beta-lactam resistance in Staphylococcus aureus.

Authors:  B J Hartman; A Tomasz
Journal:  J Bacteriol       Date:  1984-05       Impact factor: 3.490

6.  A membrane enzyme from Staphylococcus aureus which catalyzes transpeptidase, carboxypeptidase, and penicillinase activities.

Authors:  J W Kozarich; J L Strominger
Journal:  J Biol Chem       Date:  1978-02-25       Impact factor: 5.157

7.  Synthesis and antibacterial activity of 6315-S, a new member of the oxacephem antibiotic.

Authors:  T Tsuji; H Satoh; M Narisada; Y Hamashima; T Yoshida
Journal:  J Antibiot (Tokyo)       Date:  1985-04       Impact factor: 2.649

8.  Biochemical and genetical approaches to the mechanism of action of penicillin.

Authors:  B G Spratt
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  1980-05-16       Impact factor: 6.237

9.  A role in vivo for penicillin-binding protein-4 of Staphylococcus aureus.

Authors:  A W Wyke; J B Ward; M V Hayes; N A Curtis
Journal:  Eur J Biochem       Date:  1981-10

10.  Binding of beta-lactam antibiotics to penicillin-binding proteins of Staphylococcus aureus and Streptococcus faecalis: relation to antibacterial activity.

Authors:  N H Georgopapadakou; F Y Liu
Journal:  Antimicrob Agents Chemother       Date:  1980-11       Impact factor: 5.191
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  6 in total

1.  Cefoxitin does not induce production of penicillin binding protein 2a in methicillin-susceptible Staphylococcus aureus strains.

Authors:  Ana Lúcia da Costa Darini; Izabel Cristina Vanzato Palazzo
Journal:  J Clin Microbiol       Date:  2004-09       Impact factor: 5.948

2.  Role of penicillin-binding protein 2 (PBP2) in the antibiotic susceptibility and cell wall cross-linking of Staphylococcus aureus: evidence for the cooperative functioning of PBP2, PBP4, and PBP2A.

Authors:  Tomasz A Łeski; Alexander Tomasz
Journal:  J Bacteriol       Date:  2005-03       Impact factor: 3.490

3.  Complementation of the essential peptidoglycan transpeptidase function of penicillin-binding protein 2 (PBP2) by the drug resistance protein PBP2A in Staphylococcus aureus.

Authors:  M G Pinho; S R Filipe; H de Lencastre; A Tomasz
Journal:  J Bacteriol       Date:  2001-11       Impact factor: 3.490

4.  In vitro activity of S-3578, a new broad-spectrum cephalosporin active against methicillin-resistant staphylococci.

Authors:  Takaji Fujimura; Yoshinori Yamano; Isamu Yoshida; Jingoro Shimada; Shogo Kuwahara
Journal:  Antimicrob Agents Chemother       Date:  2003-03       Impact factor: 5.191

5.  Evaluation of three techniques for detection of low-level methicillin-resistant Staphylococcus aureus (MRSA): a disk diffusion method with cefoxitin and moxalactam, the Vitek 2 system, and the MRSA-screen latex agglutination test.

Authors:  Annie Felten; Bernadette Grandry; Philippe Henri Lagrange; Isabelle Casin
Journal:  J Clin Microbiol       Date:  2002-08       Impact factor: 5.948

6.  Presence of an additional penicillin-binding protein in methicillin-resistant Staphylococcus epidermidis, Staphylococcus haemolyticus, Staphylococcus hominis, and Staphylococcus simulans with a low affinity for methicillin, cephalothin, and cefamandole.

Authors:  J Pierre; R Williamson; M Bornet; L Gutmann
Journal:  Antimicrob Agents Chemother       Date:  1990-09       Impact factor: 5.191
  6 in total

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