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Literature DB >> 4008339

Synthesis and antibacterial activity of 6315-S, a new member of the oxacephem antibiotic.

T Tsuji, H Satoh, M Narisada, Y Hamashima, T Yoshida.

Abstract

The synthesis and in vitro activity of 7 beta-difluoromethylthioacetamido-7 alpha-methoxy-3-[[1-(hydroxyethyl)-1H- tetrazol-5-yl]thiomethyl]-1-oxa-3-cephem-4-carboxylic acid sodium salt, 6315-S, are described. 6315-S shows good antibacterial activity against Gram-positive and Gram-negative bacteria, being especially highly active against clinical isolates of Staphylococcus aureus resistant to either ampicillin or methicillin. The structure-activity relationship of related 1-oxa and 1-thia cephems is also presented.

Entities: Chemical Species

Mesh：

Substances：
Cephalosporins
flomoxef

Year: 1985 PMID： 4008339 DOI： 10.7164/antibiotics.38.466

Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649

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Cited

14 in total

1. In vitro effects of beta-lactams combined with beta-lactamase inhibitors against methicillin-resistant Staphylococcus aureus.

Authors: S Kobayashi; S Arai; S Hayashi; T Sakaguchi
Journal: Antimicrob Agents Chemother Date: 1989-03 Impact factor: 5.191

2. Increased susceptibility to cephamycin-type antibiotics of methicillin-resistant Staphylococcus aureus defective in penicillin-binding protein 2.

Authors: K Murakami; K Nomura; M Doi; T Yoshida
Journal: Antimicrob Agents Chemother Date: 1987-09 Impact factor: 5.191

3. Production of low-affinity penicillin-binding protein by low- and high-resistance groups of methicillin-resistant Staphylococcus aureus.

Authors: K Murakami; K Nomura; M Doi; T Yoshida
Journal: Antimicrob Agents Chemother Date: 1987-09 Impact factor: 5.191

4. In vitro activity of flomoxef in comparison to other cephalosporins.

Authors: C Simon; M Simon; C Plieth
Journal: Infection Date: 1988 Mar-Apr Impact factor: 3.553

5. Pharmacokinetics and hemostasis following administration of a new, injectable oxacephem (6315-S, flomoxef) in volunteers and in patients with renal insufficiency.

Authors: K Andrassy; J Koderisch; K Gorges; H Sonntag; K Hirauchi
Journal: Infection Date: 1991 Impact factor: 3.553

Synthesis and antibacterial activity of 6315-S, a new member of the oxacephem antibiotic.

1. In vitro effects of beta-lactams combined with beta-lactamase inhibitors against methicillin-resistant Staphylococcus aureus.

2. Increased susceptibility to cephamycin-type antibiotics of methicillin-resistant Staphylococcus aureus defective in penicillin-binding protein 2.

3. Production of low-affinity penicillin-binding protein by low- and high-resistance groups of methicillin-resistant Staphylococcus aureus.

4. In vitro activity of flomoxef in comparison to other cephalosporins.

5. Pharmacokinetics and hemostasis following administration of a new, injectable oxacephem (6315-S, flomoxef) in volunteers and in patients with renal insufficiency.

6. In vitro activity of flomoxef and cefazolin in combination with vancomycin.

7. Effect of flomoxef on blood coagulation and alcohol metabolism.

Review 8. The evolving role of chemical synthesis in antibacterial drug discovery.

9. In vitro activity and beta-lactamase stability of a new difluoro oxacephem, 6315-S.

10. In vitro and in vivo activities of SCE-2787, a new parenteral cephalosporin with a broad antibacterial spectrum.