Literature DB >> 3499584

Tomographic studies of rCBF with 99mTc-HM-PAO SPECT in comparison with PET in patients with primary brain tumors.

K J Langen1, H Herzog, E Rota, N Roosen, H Wieler, J Kiwit, T Kuwert, A Storch-Becker, L Feinendegen.   

Abstract

99mTc-hexamethyl-propyleneamine-oxime (HM-PAO) was developed as a radiotracer of regional cerebral blood flow (rCBF) with SPECT. THe purpose of this study was to investigate if HM-PAO is able to trace rCBF in primary brain tumors. In 10 patients with glioblastoma grade IV the intracerebral distribution of HM-PAO was studied in comparison with C15O2 steady state inhalation technique and PET for rCBF evaluation. In all instances the cerebral HM-PAO distribution was comparable with rCBF pattern as confirmed by a significant correlation of tumor to cortex ratios. The results indicate the clinical usefulness of HM-PAO for tracing rCBF in brain tumors.

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Year:  1987        PMID： 3499584     DOI： 10.1007/BF01780589

Source DB:  PubMed          Journal:  Neurosurg Rev        ISSN： 0344-5607            Impact factor:   3.042


  4 in total

Review 1.  The role of positron emission tomography in the study of cerebral tumors.

Authors:  D J Brooks; R P Beaney; D G Thomas
Journal:  Semin Oncol       Date:  1986-03       Impact factor: 4.929

2.  Quantitative measurement of regional cerebral blood flow and oxygen metabolism in man using 15O and positron emission tomography: theory, procedure, and normal values.

Authors:  R S Frackowiak; G L Lenzi; T Jones; J D Heather
Journal:  J Comput Assist Tomogr       Date:  1980-12       Impact factor: 1.826

3.  A 99Tcm-labelled radiotracer for the investigation of cerebral vascular disease.

Authors:  P J Ell; J M Hocknell; P H Jarritt; I Cullum; D Lui; D Campos-Costa; D P Nowotnik; R D Pickett; L R Canning; R D Neirinckx
Journal:  Nucl Med Commun       Date:  1985-08       Impact factor: 1.690

4.  Cerebral dynamics of N-isopropyl-(123I)p-iodoamphetamine.

Authors:  H Creutzig; O Schober; P Gielow; R Friedrich; H Becker; H Dietz; H Hundeshagen
Journal:  J Nucl Med       Date:  1986-02       Impact factor: 10.057
  4 in total
  4 in total

1.  Brain perfusion with intracarotid injection of 99mTc-HM-PAO in partial epilepsy during amobarbital testing.

Authors:  S O Hietala; H Silfvenius; J Aasly; M Olivecrona; L Jonsson
Journal:  Eur J Nucl Med       Date:  1990

2.  Evaluation of primary lung carcinoma using technetium 99m-hexamethylpropylene amine oxime: preliminary clinical experience.

Authors:  M Oshima; K Itoh; S Okae; M Tadokoro; Y Kodama; S Sakuma
Journal:  Eur J Nucl Med       Date:  1990

3.  An evaluation of 99mTc-HMPAO uptake in cerebral gliomas--a comparison with X-ray CT.

Authors:  A T Irvine; M A Flower; R J Ott; J W Babich; F Kabir; V R McCready
Journal:  Eur J Nucl Med       Date:  1990

4.  Sensitivity and specificity of thallium-201 single-photon emission tomography in the functional detection and differential diagnosis of brain tumours.

Authors:  R A Dierckx; J J Martin; A Dobbeleir; R Crols; I Neetens; P P De Deyn
Journal:  Eur J Nucl Med       Date:  1994-07
  4 in total

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