Literature DB >> 6971299

Quantitative measurement of regional cerebral blood flow and oxygen metabolism in man using 15O and positron emission tomography: theory, procedure, and normal values.

R S Frackowiak, G L Lenzi, T Jones, J D Heather.   

Abstract

A method is described for quantifying regional cerebral blood flow (rCBF), oxygen extraction (rOER), and oxygen utilization (rCMRO2) in man non-invasively, using inhaled 15O-labeled CO2 and O2 and positron emission tomography. The theoretical considerations and practical aspects are described. The results of rCBF, rCMRO2, and rOER for gray and white matter in normal volunteers are presented. The significance and limitations of the results are discussed. The method appears suitable for the study of human cerebral aerobic metabolism and blood flow under differing physiological conditions and in a wide variety of neurological disorders.

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Year:  1980        PMID： 6971299     DOI： 10.1097/00004728-198012000-00001

Source DB:  PubMed          Journal:  J Comput Assist Tomogr        ISSN： 0363-8715            Impact factor:   1.826


  213 in total

1.  Progressive frontal gait disturbance with atypical Alzheimer's disease and corticobasal degeneration.

Authors:  M N Rossor; P J Tyrrell; E K Warrington; P D Thompson; C D Marsden; P Lantos
Journal:  J Neurol Neurosurg Psychiatry       Date:  1999-09       Impact factor: 10.154

2.  A default mode of brain function.

Authors:  M E Raichle; A M MacLeod; A Z Snyder; W J Powers; D A Gusnard; G L Shulman
Journal:  Proc Natl Acad Sci U S A       Date:  2001-01-16       Impact factor: 11.205

3.  Quantitative measurements of cerebral metabolic rate of oxygen utilization using MRI: a volunteer study.

Authors:  H An; W Lin; A Celik; Y Z Lee
Journal:  NMR Biomed       Date:  2001 Nov-Dec       Impact factor: 4.044

4.  Apparent brain temperature imaging with multi-voxel proton magnetic resonance spectroscopy compared with cerebral blood flow and metabolism imaging on positron emission tomography in patients with unilateral chronic major cerebral artery steno-occlusive disease.

Authors:  Takamasa Nanba; Hideaki Nishimoto; Yoshichika Yoshioka; Toshiyuki Murakami; Makoto Sasaki; Ikuko Uwano; Shunrou Fujiwara; Kazunori Terasaki; Kuniaki Ogasawara
Journal:  Neuroradiology       Date:  2017-08-03       Impact factor: 2.804

5.  The impact of increased mean airway pressure on contrast-enhanced MRI measurement of regional cerebral blood flow (rCBF), regional cerebral blood volume (rCBV), regional mean transit time (rMTT), and regional cerebrovascular resistance (rCVR) in human volunteers.

Authors:  C Kolbitsch; I H Lorenz; C Hörmann; M Schocke; C Kremser; F Zschiegner; S Felber; A Benzer
Journal:  Hum Brain Mapp       Date:  2000-11       Impact factor: 5.038

6.  Quantitative cerebral blood flow measurement with dynamic perfusion CT using the vascular-pixel elimination method: comparison with H2(15)O positron emission tomography.

Authors:  Kohsuke Kudo; Satoshi Terae; Chietsugu Katoh; Masaki Oka; Tohru Shiga; Nagara Tamaki; Kazuo Miyasaka
Journal:  AJNR Am J Neuroradiol       Date:  2003-03       Impact factor: 3.825

7.  Early and delayed single photon emission CT in various cerebral diseases using N-isopropyl-p-(123I)iodoamphetamine.

Authors:  T Ueda; K Kinoshita; K Watanabe; H Hoshi; S Jinnouchi
Journal:  Neuroradiology       Date:  1988       Impact factor: 2.804

8.  Acetazolamide-Loaded Dynamic 7T MR Quantitative Susceptibility Mapping in Major Cerebral Artery Steno-Occlusive Disease: Comparison with PET.

Authors:  K Fujimoto; I Uwano; M Sasaki; S Oshida; S Tsutsui; W Yanagihara; S Fujiwara; M Kobayashi; Y Kubo; K Yoshida; K Terasaki; K Ogasawara
Journal:  AJNR Am J Neuroradiol       Date:  2020-04-16       Impact factor: 3.825

9.  Rapid measurement of regional cerebral blood flow in the baboon using 15O-labelled water and dynamic positron emission tomography.

Authors:  E Pinard; B Mazoyer; B Verrey; S Pappata; C Crouzel
Journal:  Med Biol Eng Comput       Date:  1993-09       Impact factor: 2.602

10.  Brain metabolism after recurrent insulin induced hypoglycaemic episodes: a PET study.

Authors:  H Chabriat; C Sachon; M Levasseur; A Grimaldi; S Pappata; D Rougemont; M C Masure; A De Recondo; Y Samson
Journal:  J Neurol Neurosurg Psychiatry       Date:  1994-11       Impact factor: 10.154
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