Isa S K Mohammed1, Sang Tran1, Luis A Toledo-Espiett1, Wuqaas M Munir2. 1. Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, 419 W Redwood Street, Suite 470, Baltimore, MD, 21201, USA. 2. Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, 419 W Redwood Street, Suite 470, Baltimore, MD, 21201, USA. wmunir@som.umaryland.edu.
Abstract
PURPOSE: To determine through a feasibility study whether anterior and posterior corneal arc length and cross-sectional area measured using anterior segment ocular coherence tomography (AS-OCT) can distinguish between healthy and keratoconic corneas. METHODS: Patients diagnosed with keratoconus along with healthy controls underwent AS-OCT. ImageJ was used to determine the central 6 mm anterior and posterior corneal arc lengths and cross-sectional areas. Each length and area was then divided into 1-mm segment and relative differences compared. RESULTS: Twenty-five eyes from 15 patients with keratoconus, along with 25 eyes from 14 healthy controls were enrolled. There was a statistically significant difference in anterior and posterior corneal arc lengths as well as corneal cross-sectional area (p = 0.006, p = 0.005, p = 0.01, respectively). When selecting for the less advanced keratoconus eye, it was noted that posterior corneal arc length was longer in the paracentral temporal segment (1003 vs. 1010 µm, p = 0.04) and that greater change in corneal cross-sectional areas occurred between adjacent segments in less advanced keratoconus eyes. CONCLUSION: AS-OCT is capable of reliably measuring corneal arc lengths in patients with keratoconus and healthy patients. Both anterior and posterior corneal arc lengths along with central cross-sectional areas are statistically different between healthy and keratoconus eyes.
PURPOSE: To determine through a feasibility study whether anterior and posterior corneal arc length and cross-sectional area measured using anterior segment ocular coherence tomography (AS-OCT) can distinguish between healthy and keratoconic corneas. METHODS: Patients diagnosed with keratoconus along with healthy controls underwent AS-OCT. ImageJ was used to determine the central 6 mm anterior and posterior corneal arc lengths and cross-sectional areas. Each length and area was then divided into 1-mm segment and relative differences compared. RESULTS: Twenty-five eyes from 15 patients with keratoconus, along with 25 eyes from 14 healthy controls were enrolled. There was a statistically significant difference in anterior and posterior corneal arc lengths as well as corneal cross-sectional area (p = 0.006, p = 0.005, p = 0.01, respectively). When selecting for the less advanced keratoconus eye, it was noted that posterior corneal arc length was longer in the paracentral temporal segment (1003 vs. 1010 µm, p = 0.04) and that greater change in corneal cross-sectional areas occurred between adjacent segments in less advanced keratoconus eyes. CONCLUSION: AS-OCT is capable of reliably measuring corneal arc lengths in patients with keratoconus and healthy patients. Both anterior and posterior corneal arc lengths along with central cross-sectional areas are statistically different between healthy and keratoconus eyes.
Authors: Renato Ambrósio; Ana Laura C Caiado; Frederico P Guerra; Ricardo Louzada; Roy A Sinha; Allan Luz; William J Dupps; Michael W Belin Journal: J Refract Surg Date: 2011-07-29 Impact factor: 3.573
Authors: A B Nesburn; S Bahri; J Salz; Y S Rabinowitz; E Maguen; J Hofbauer; M Berlin; J I Macy Journal: J Refract Surg Date: 1995 May-Jun Impact factor: 3.573