Literature DB >> 34949922

Chitosan Nanoparticles for Antiviral Drug Delivery: A Novel Route for COVID-19 Treatment.

Abdel-Majed Safer1, Stefano Leporatti2.   

Abstract

Chitosan has been investigated in several biological fields, including drug and gene delivery, tissue engineering antiviral and immunological adjuvant methods. It's a cationic copolymer of N-acetyl glucosamine and D-glucosamine with different molecular chain lengths, compositions, and sequences than N-acetyl glucosamine and D-glucosamine. It is biocompatible and cyto-compatible, as well as recyclable and bioresorbable. As effective drug delivery methods, chitosan nanoparticles are shaped into several pathways. The purpose of this article is to provide an overview of its antiviral application as a nanocarrier for antiviral medications, highlighting the benefits, limitations, and downsides. In this review, we will report the most recent COVID-19 vaccination advances. It will also be discussed what the future holds for chitosan nanoparticles in the treatment of coronaviruses.
© 2021 Safer and Leporatti.

Entities:  

Keywords:  COVID-19; antivirals; chitosan; drug delivery; nanoparticles

Mesh:

Substances:

Year:  2021        PMID: 34949922      PMCID: PMC8689047          DOI: 10.2147/IJN.S332385

Source DB:  PubMed          Journal:  Int J Nanomedicine        ISSN: 1176-9114


  65 in total

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Review 2.  Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC) for pulmonary application: a review of the state of the art.

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Journal:  Eur J Pharm Biopharm       Date:  2013-09-02       Impact factor: 5.571

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Journal:  Thorax       Date:  2004-03       Impact factor: 9.139

Review 4.  Targeting endosomal acidification by chloroquine analogs as a promising strategy for the treatment of emerging viral diseases.

Authors:  Md Abdul Alim Al-Bari
Journal:  Pharmacol Res Perspect       Date:  2017-01-23

5.  Biodegradability and biocompatibility study of poly(chitosan-g-lactic acid) scaffolds.

Authors:  Zhe Zhang; Huifei Cui
Journal:  Molecules       Date:  2012-03-14       Impact factor: 4.411

Review 6.  Effects of chloroquine on viral infections: an old drug against today's diseases?

Authors:  Andrea Savarino; Johan R Boelaert; Antonio Cassone; Giancarlo Majori; Roberto Cauda
Journal:  Lancet Infect Dis       Date:  2003-11       Impact factor: 25.071

Review 7.  Chitosan Nanoparticles-Insight into Properties, Functionalization and Applications in Drug Delivery and Theranostics.

Authors:  Jhanvi Jhaveri; Zarna Raichura; Tabassum Khan; Munira Momin; Abdelwahab Omri
Journal:  Molecules       Date:  2021-01-07       Impact factor: 4.411

8.  Nano-Enabled COVID-19 Vaccines: Meeting the Challenges of Durable Antibody Plus Cellular Immunity and Immune Escape.

Authors:  André E Nel; Jeff F Miller
Journal:  ACS Nano       Date:  2021-04-01       Impact factor: 15.881

Review 9.  Application prospect of polysaccharides in the development of anti-novel coronavirus drugs and vaccines.

Authors:  Xiangyan Chen; Wenwei Han; Guixiang Wang; Xia Zhao
Journal:  Int J Biol Macromol       Date:  2020-07-14       Impact factor: 6.953

10.  COVID-19: A Call for Physical Scientists and Engineers.

Authors:  Haiyue Huang; Chunhai Fan; Min Li; Hua-Li Nie; Fu-Bing Wang; Hui Wang; Ruilan Wang; Jianbo Xia; Xin Zheng; Xiaolei Zuo; Jiaxing Huang
Journal:  ACS Nano       Date:  2020-04-08       Impact factor: 15.881

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