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Literature DB >> 3493204

Immunological responses of the BB rat colony in Edinburgh.

A M Varey, B M Dean, R Walker, A J Bone, J D Baird, A Cooke.

Abstract

Several immunological responses of the spontaneously diabetic BB rat colony in Edinburgh designated (BB/E) have been studied. The proliferative responses to Con A and LPS, ability to make IL-2 and to show NK activity have been studied using diabetic and non-diabetic BB/E rats and normal Wistar rats. Our data suggest that the diabetic animals in the BB/E colony do not have marked deficiencies in any of these parameters. Lymphopenia and depressed T-cell responses do not appear to be a prerequisite for the development of diabetes in the BB/E colony.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1987 PMID： 3493204 PMCID： PMC1453364

Source DB: PubMed Journal: Immunology ISSN： 0019-2805 Impact factor: 7.397

10 in total

Review 1. Altered immunity and diabetes in the BB rat.

Authors: J F Yale; E B Marliss
Journal: Clin Exp Immunol Date: 1984-07 Impact factor: 4.330

2. Lymphocyte abnormalities in the BB rat.

Authors: R Jackson; P Kadison; J Buse; N Rassi; B Jegasothy; G S Eisenbarth
Journal: Metabolism Date: 1983-07 Impact factor: 8.694

3. Transfusions of whole blood prevent spontaneous diabetes mellitus in the BB/W rat.

Authors: A A Rossini; J P Mordes; A M Pelletier; A A Like
Journal: Science Date: 1983-02-25 Impact factor: 47.728

4. Deficiency of phenotypic cytotoxic-suppressor T lymphocytes in the BB/W rat.

Authors: B A Woda; A A Like; C Padden; M L McFadden
Journal: J Immunol Date: 1986-02-01 Impact factor: 5.422

5. Identification of profound peripheral T lymphocyte immunodeficiencies in the spontaneously diabetic BB rat.

Authors: M E Elder; N K Maclaren
Journal: J Immunol Date: 1983-04 Impact factor: 5.422

6. Spontaneous diabetes mellitus syndrome in the rat. II. T lymphopenia and its association with clinical disease and pancreatic lymphocytic infiltration.

Authors: R D Guttmann; E Colle; F Michel; T Seemayer
Journal: J Immunol Date: 1983-04 Impact factor: 5.422

7. Autoimmune diatheses and T lymphocyte immunoincompetences in BB rats.

Authors: N K Maclaren; M E Elder; V W Robbins; W J Riley
Journal: Metabolism Date: 1983-07 Impact factor: 8.694

8. Spontaneous diabetes in BB rats: evidence for a T cell dependent immune response defect.

Authors: D Bellgrau; A Naji; W K Silvers; J F Markmann; C F Barker
Journal: Diabetologia Date: 1982-10 Impact factor: 10.122

9. Spontaneous diabetes mellitus syndrome in the rat. I. Association with the major histocompatibility complex.

Authors: E Colle; R D Guttmann; T Seemayer
Journal: J Exp Med Date: 1981-10-01 Impact factor: 14.307

10. Immune dysfunction in diabetes-prone BB rats. Interleukin 2 production and other mitogen-induced responses are suppressed by activated macrophages.

Authors: G J Prud'homme; A Fuks; E Colle; T A Seemayer; R D Guttmann
Journal: J Exp Med Date: 1984-02-01 Impact factor: 14.307