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Literature DB >> 6823559

Transfusions of whole blood prevent spontaneous diabetes mellitus in the BB/W rat.

A A Rossini, J P Mordes, A M Pelletier, A A Like.

Abstract

Weekly transfusions of whole blood from a nondiabetic subline of BB/W rats reduced the incidence of diabetes in susceptible BB/W rats from 39 to 0 percent and the incidence of pancreatic insulitis from 64 to 6 percent. Responsiveness of lymphocytes to concanavalin A was found to be low in rats with diabetes or insulitis. Transfusion restored concanavalin A responsiveness to levels observed in control rats free of diabetes or insulitis. These data suggest that whole blood alters the course of autoimmune BB/W rat diabetes.

Entities: Disease Species

Mesh：

Year: 1983 PMID： 6823559 DOI： 10.1126/science.6823559

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

26 in total

1. Diabetes mellitus in the BB/W rat. Insulitis in pancreatic islet grafts after transplantation in diabetic recipients.

Authors: E J Weringer; A A Like
Journal: Am J Pathol Date: 1986-10 Impact factor: 4.307

2. Spleen cell transfusion in the Bio-Breeding/Worcester rat. Prevention of diabetes, major histocompatibility complex restriction, and long-term persistence of transfused cells.

Authors: A A Rossini; J P Mordes; D L Greiner; K Nakano; M C Appel; E S Handler
Journal: J Clin Invest Date: 1986-04 Impact factor: 14.808

10. Identification of T cell subsets and class I and class II antigen expression in islet grafts and pancreatic islets of diabetic BioBreeding/Worcester rats.

Authors: E J Weringer; A A Like
Journal: Am J Pathol Date: 1988-08 Impact factor: 4.307

Transfusions of whole blood prevent spontaneous diabetes mellitus in the BB/W rat.

1. Diabetes mellitus in the BB/W rat. Insulitis in pancreatic islet grafts after transplantation in diabetic recipients.

2. Spleen cell transfusion in the Bio-Breeding/Worcester rat. Prevention of diabetes, major histocompatibility complex restriction, and long-term persistence of transfused cells.

3. Immunopathology of diabetes in the RT6-depleted diabetes-resistant BB/Wor rat.

Review 4. Cellular basis of T-cell autoreactivity in autoimmune diseases.

5. Prevention of diabetes mellitus in the BB/W rat with Cyclosporin-A.

6. Islet cell surface and lymphocyte antibodies often precede the spontaneous diabetes in the BB rat.

7. Lymphocyte transfusions prevent diabetes in the Bio-Breeding/Worcester rat.

Review 8. The role of immunotherapy in type I diabetes mellitus.

9. Promotion of diabetes onset by stress in the BB rat.

10. Identification of T cell subsets and class I and class II antigen expression in islet grafts and pancreatic islets of diabetic BioBreeding/Worcester rats.