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Literature DB >> 2934480

Deficiency of phenotypic cytotoxic-suppressor T lymphocytes in the BB/W rat.

B A Woda, A A Like, C Padden, M L McFadden.

Abstract

The BB/W rat is currently the best model of type I (insulin dependent diabetes). Even though this rat develops an autoimmune disease, they are immune deficient. In this study we have demonstrated the almost complete absence of the OX 8+, OX 19+ T cytotoxic/suppressor population in diabetes prone and acute diabetic rats. This population is present in the diabetes resistant W line. The diabetes prone and acute diabetic rats have a relative increase in OX 8+, OX 19- natural killer (NK) cells. Our data suggests that virtually all OX 8+ cells in diabetes prone and acute diabetic animals are phenotypic NK cells.

Entities: Disease Species

Mesh：

Substances：
Antibodies, Monoclonal

Year: 1986 PMID： 2934480

Source DB: PubMed Journal: J Immunol ISSN： 0022-1767 Impact factor: 5.422

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Cited

27 in total

1. Elevated apoptosis of peripheral T lymphocytes in diabetic BB rats.

Authors: C G Jung; T Kamiyama; T Agui
Journal: Immunology Date: 1999-12 Impact factor: 7.397

2. Lactate production is the major metabolic fate of glucose in splenocytes and is altered in spontaneously diabetic BB rats.

Authors: C J Field; G Wu; M D Métroz-Dayer; M Montambault; E B Marliss
Journal: Biochem J Date: 1990-12-01 Impact factor: 3.857

3. Cytotoxic T-cell precursors with low-level CD8 in the diabetes-prone Biobreeding rat: implications for generation of an autoimmune T-cell repertoire.

Authors: D Bellgrau; A C Lagarde
Journal: Proc Natl Acad Sci U S A Date: 1990-01 Impact factor: 11.205

10. Identification of a limited T-cell receptor beta chain variable region repertoire associated with diabetes in the BB rat.

Authors: D P Gold; D Bellgrau
Journal: Proc Natl Acad Sci U S A Date: 1991-11-01 Impact factor: 11.205

Deficiency of phenotypic cytotoxic-suppressor T lymphocytes in the BB/W rat.

1. Elevated apoptosis of peripheral T lymphocytes in diabetic BB rats.

2. Lactate production is the major metabolic fate of glucose in splenocytes and is altered in spontaneously diabetic BB rats.

3. Cytotoxic T-cell precursors with low-level CD8 in the diabetes-prone Biobreeding rat: implications for generation of an autoimmune T-cell repertoire.

4. Kinetics of T cell turnover following thymectomy.

5. Neonatal development of lymphoid organs and specific immune responses in situ in diabetes-prone BB rats.

6. Natural killer cell depletion and diabetes mellitus in the BB/Wor rat (revisited).

7. Anti-CD2 monoclonal antibodies prevent spontaneous and adoptive transfer of diabetes in the BB/Wor rat.

8. BB-DR/Edinburgh: a lymphopenic, non-diabetic subline of BB rats.

9. Adoptive transfer of diabetes to and from old normoglycaemic BB rats.

10. Identification of a limited T-cell receptor beta chain variable region repertoire associated with diabetes in the BB rat.