M Gao 1 , L Cao 1 , H Wang 1 , R Peng 1 , X Xiao 1 , G Wang 1 , Y Gao 1 , G Wang 1 , C Sun 1 Show Affiliations »
Abstract
CONTEXT: It is well known that thyroid hormones are important, being involved in affects the metabolism of carbohydrate, protein, lipids. The relationship between thyroid hormones and lipid metabolism is the focus of recent research. OBJECTIVE: To investigate the relationship between subclinical hypothyroidism and lipid metabolism in women. DESIGN: We conducted an epidemiological survey of thyroid diseases among women in Northeast China from September 2014 to December 2014. SUBJECTS AND METHODS: A total of 1397 women underwent physical examinations and laboratory tests for thyroid function and lipid metabolism. RESULTS: We found that the detection rate of subclinical hypothyroidism was 13.03%. Patients with subclinical hypothyroidism showed significantly higher levels of triglyceride (1.69±1.9 vs. 1.45±1.4) and the risk of hyper triglyceridemia in women with thyroid stimulating hormone (TSH) levels ≥10mIU/L was 4.96-fold higher compared with that in the normal population (P<0.01). CONCLUSION: Disorders of lipid metabolism in women with subclinical hypothyroidism show a direct correlation with the level of TSH, and the risk of hyper triglyceridemia is significantly increased when the level of TSH ≥10mIU/L. ©by Acta Endocrinologica Foundation.
CONTEXT: It is well known that thyroid hormones are important, being involved in affects the metabolism of carbohydrate, protein, lipids. The relationship between thyroid hormones and lipid metabolism is the focus of recent research. OBJECTIVE: To investigate the relationship between subclinical hypothyroidism and lipid metabolism in women. DESIGN: We conducted an epidemiological survey of thyroid diseases among women in Northeast China from September 2014 to December 2014. SUBJECTS AND METHODS: A total of 1397 women underwent physical examinations and laboratory tests for thyroid function and lipid metabolism. RESULTS: We found that the detection rate of subclinical hypothyroidism was 13.03%. Patients with subclinical hypothyroidism showed significantly higher levels of triglyceride (1.69±1.9 vs. 1.45±1.4) and the risk of hyper triglyceridemia in women with thyroid stimulating hormone (TSH) levels ≥10mIU/L was 4.96-fold higher compared with that in the normal population (P<0.01). CONCLUSION: Disorders of lipid metabolism in women with subclinical hypothyroidism show a direct correlation with the level of TSH, and the risk of hyper triglyceridemia is significantly increased when the level of TSH ≥10mIU/L. ©by Acta Endocrinologica Foundation.
Entities: Chemical
Keywords:
dyslipidemia; subclinical hypothyroidism; thyroid stimulating hormone
Year: 2021
PMID： 34925583 PMCID： PMC8665239 DOI： 10.4183/aeb.2021.282
Source DB: PubMed Journal: Acta Endocrinol (Buchar) ISSN： 1841-0987 Impact factor: 0.877