Savas Guzel1, Arzu Seven2, Eda Celik Guzel3, Banu Buyuk4, Aslan Celebi4, Birsen Aydemir5. 1. a Medical Faculty, Department of Biochemistry, Namik Kemal University , Tekirdag, Turkey. 2. b Cerrahpasa Medical Faculty, Department of Biochemistry, Istanbul University , Istanbul, Turkey. 3. c Medical Faculty, Department of Family Physcian, Namik Kemal University , Tekirdag, Turkey. 4. d Department of Internal Medicine, Taksim Training and Research Hospital , Istanbul, Turkey. 5. e Medical Faculty, Department of Biophysic, Sakarya University , Sakarya, Turkey.
Abstract
PURPOSE: This study is designed to evaluate the interrelationships among adipokines-visfatin, leptin, and tumor necrosis factor-α (TNF-α)- and insulin resistance (IR) in overt (n = 40) and subclinic hypothyroid (n = 25) patients and compare our findings with sex and body mass index-matched healthy controls (n = 25). METHODS: Serum visfatin, leptin, and TNF-α levels were measured by enzyme-linked immunosorbent assay and C-reactive protein by immunoturbidimetry. Thyroid status (TSH, FT3, FT4) and lipid status (triglyceride, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol, total cholesterol) parameters were measured. IR was determined by homeostatic model assessment (HOMA-IR) and McAuley (McA) indices. RESULTS: HOMA-IR (p < 0.05) and McA indices (p < 0.01) revealed the presence of IR in overt hypothyroid patients. C-reactive protein, TNF-α, leptin, and visfatin levels were significantly higher (p < 0.01, p < 0.01, p < 0.001, and p < 0.001) in overt hypothyroid patients than euthyroid control group. Subclinic hypothyroid patients were observed to have significantly higher leptin and visfatin levels (p < 0.05) than euthyroid control group. In overt hypothyroid patients, we found plasma visfatin to be significantly positively correlated with HOMA-IR index (r = 0.336, p < 0.05) and body mass index (r = 0.445, p < 0.01) and negatively correlated with McA index (r = -0.574, p < 0.01). CONCLUSION: This study demonstrates the presence of IR in overt hypothyroid patients by HOMA and McA indices. Increased levels of visfatin, leptin, and TNF-α in overt and subclinic hypothyroid patients and the correlations among these adipokines highlighten their crucial role in the IR-associated disorders.
PURPOSE: This study is designed to evaluate the interrelationships among adipokines-visfatin, leptin, and tumor necrosis factor-α (TNF-α)- and insulin resistance (IR) in overt (n = 40) and subclinic hypothyroid (n = 25) patients and compare our findings with sex and body mass index-matched healthy controls (n = 25). METHODS: Serum visfatin, leptin, and TNF-α levels were measured by enzyme-linked immunosorbent assay and C-reactive protein by immunoturbidimetry. Thyroid status (TSH, FT3, FT4) and lipid status (triglyceride, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol, total cholesterol) parameters were measured. IR was determined by homeostatic model assessment (HOMA-IR) and McAuley (McA) indices. RESULTS: HOMA-IR (p < 0.05) and McA indices (p < 0.01) revealed the presence of IR in overt hypothyroidpatients. C-reactive protein, TNF-α, leptin, and visfatin levels were significantly higher (p < 0.01, p < 0.01, p < 0.001, and p < 0.001) in overt hypothyroidpatients than euthyroid control group. Subclinic hypothyroidpatients were observed to have significantly higher leptin and visfatin levels (p < 0.05) than euthyroid control group. In overt hypothyroidpatients, we found plasma visfatin to be significantly positively correlated with HOMA-IR index (r = 0.336, p < 0.05) and body mass index (r = 0.445, p < 0.01) and negatively correlated with McA index (r = -0.574, p < 0.01). CONCLUSION: This study demonstrates the presence of IR in overt hypothyroidpatients by HOMA and McA indices. Increased levels of visfatin, leptin, and TNF-α in overt and subclinic hypothyroidpatients and the correlations among these adipokines highlighten their crucial role in the IR-associated disorders.
Authors: Š Sotak; Z Schroner; I Lazúrová; M Felšőci; I Jochmanová; D Petrášová; I Bertková; M Mitníková; B Nováková; H Wagnerová; O Bobelová Journal: Physiol Res Date: 2021-10-30 Impact factor: 1.881
Authors: Marjory Alana Marcello; Antonio Ramos Calixto; Jacqueline Fatima Martins de Almeida; Mariana Bonjiorno Martins; Lucas Leite Cunha; Camila Ayume Amano Cavalari; Elba C S Etchebehere; Ligia Vera Montalli da Assumpção; Bruno Geloneze; Andre Lopes Carvalho; Laura Sterian Ward Journal: Int J Endocrinol Date: 2015-02-25 Impact factor: 3.257