Lijuan Wu1, Yong Hu2, Xiangzhou Zhang3, Jia Zhang4, Mei Liu5. 1. Big Data Decision Institute, Jinan University, Guangzhou 510632, China; Guangdong Engineering Technology Research Center for Big Data Precision Healthcare, Guangzhou 510632, China. Electronic address: wulj1989@163.com. 2. Big Data Decision Institute, Jinan University, Guangzhou 510632, China; Guangdong Engineering Technology Research Center for Big Data Precision Healthcare, Guangzhou 510632, China. Electronic address: henryhu200211@163.com. 3. Big Data Decision Institute, Jinan University, Guangzhou 510632, China; Guangdong Engineering Technology Research Center for Big Data Precision Healthcare, Guangzhou 510632, China. 4. The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China. 5. Department of Internal Medicine, Division of Medical Informatics, University of Kansas Medical Center, Kansas City 66160, USA. Electronic address: meiliu@kumc.edu.
Abstract
OBJECTIVES: Acute kidney injury (AKI) risk increases with age and the underlying clinical predictors may be heterogeneous across age strata. This study aims to uncover the AKI risk factor heterogeneity among general inpatients across age groups using electronic medical records (EMR). METHODS: Patient data (n = 179,370 encounters) were collected from an academic hospital between 2007 and 2016, and were stratified into four age groups: 18-35, 36-55, 56-65, and > 65. Potential risk factors extracted for the cohort included demographics, vital signs, laboratory values, past medical diagnoses, medications and admission diagnoses. We developed a data driven knowledge mining approach consisting of a machine learning algorithm to identify AKI predictors across age strata and a statistical method to quantify the impact of those factors on AKI risk. Identified predictors were evaluated for their predictability of AKI in terms of area-under-the-receiver-operating-characteristic-curve (AUC) and validated against expert knowledge. RESULTS: Among the final analysis cohort of 76,957 hospital admissions, AKI prediction across age groups 18-35 (16.73%), 36-55 (32.74%), 56-65 (23.52%), and > 65 years (27.01%) achieved AUC of 0.85 (95% CI, 0.80-0.88), 0.86 (95% CI, 0.83-0.89), 0.87 (95% CI, 0.86-0.90), and 0.87 (95% CI, 0.86-0.90), respectively. Compared to expert knowledge, absolute consistency rates of the top-150 identified risk factors for each group were 78.4%, 77.2%, 81.3%, and 79.5%, respectively. Impact of many predictors on AKI varied across age groups; for example, high body mass index (BMI) was found to be associated with higher AKI risk in elderly patients, but low BMI was found to be associated with higher AKI risk in younger patients. CONCLUSIONS: We verified the effectiveness of the knowledge mining method from the perspectives of accuracy, stability and credibility, and used this approach to clarify the heterogeneity of AKI risk factors between age groups. Future decision support systems need to consider such heterogeneity to enhance personalized patient care.
OBJECTIVES: Acute kidney injury (AKI) risk increases with age and the underlying clinical predictors may be heterogeneous across age strata. This study aims to uncover the AKI risk factor heterogeneity among general inpatients across age groups using electronic medical records (EMR). METHODS: Patient data (n = 179,370 encounters) were collected from an academic hospital between 2007 and 2016, and were stratified into four age groups: 18-35, 36-55, 56-65, and > 65. Potential risk factors extracted for the cohort included demographics, vital signs, laboratory values, past medical diagnoses, medications and admission diagnoses. We developed a data driven knowledge mining approach consisting of a machine learning algorithm to identify AKI predictors across age strata and a statistical method to quantify the impact of those factors on AKI risk. Identified predictors were evaluated for their predictability of AKI in terms of area-under-the-receiver-operating-characteristic-curve (AUC) and validated against expert knowledge. RESULTS: Among the final analysis cohort of 76,957 hospital admissions, AKI prediction across age groups 18-35 (16.73%), 36-55 (32.74%), 56-65 (23.52%), and > 65 years (27.01%) achieved AUC of 0.85 (95% CI, 0.80-0.88), 0.86 (95% CI, 0.83-0.89), 0.87 (95% CI, 0.86-0.90), and 0.87 (95% CI, 0.86-0.90), respectively. Compared to expert knowledge, absolute consistency rates of the top-150 identified risk factors for each group were 78.4%, 77.2%, 81.3%, and 79.5%, respectively. Impact of many predictors on AKI varied across age groups; for example, high body mass index (BMI) was found to be associated with higher AKI risk in elderly patients, but low BMI was found to be associated with higher AKI risk in younger patients. CONCLUSIONS: We verified the effectiveness of the knowledge mining method from the perspectives of accuracy, stability and credibility, and used this approach to clarify the heterogeneity of AKI risk factors between age groups. Future decision support systems need to consider such heterogeneity to enhance personalized patient care.
Authors: Scott M Lundberg; Gabriel Erion; Hugh Chen; Alex DeGrave; Jordan M Prutkin; Bala Nair; Ronit Katz; Jonathan Himmelfarb; Nisha Bansal; Su-In Lee Journal: Nat Mach Intell Date: 2020-01-17
Authors: Eric A J Hoste; Sean M Bagshaw; Rinaldo Bellomo; Cynthia M Cely; Roos Colman; Dinna N Cruz; Kyriakos Edipidis; Lui G Forni; Charles D Gomersall; Deepak Govil; Patrick M Honoré; Olivier Joannes-Boyau; Michael Joannidis; Anna-Maija Korhonen; Athina Lavrentieva; Ravindra L Mehta; Paul Palevsky; Eric Roessler; Claudio Ronco; Shigehiko Uchino; Jorge A Vazquez; Erick Vidal Andrade; Steve Webb; John A Kellum Journal: Intensive Care Med Date: 2015-07-11 Impact factor: 17.440