AIMS: Although surgical aortic valve replacement (SAVR) is currently the recommended intervention for patients with native AR without aortic stenosis, a significant proportion of Asian patients undergo transcatheter aortic valve replacement (TAVR), which has not been studied fully for safety and outcomes. This systematic review aims to examine the characteristics and outcomes of Asian patients with pure native aortic regurgitation (AR) undergoing TAVR. METHODS AND RESULTS: PubMed, Embase, Scopus, Web of Science and Cochrane CENTRAL were systematically searched for randomised controlled trials, observational studies and case reports published from inception to 2 April 2020, involving patients of Asian ethnicity with pure native aortic regurgitation who had undergone TAVR. Our primary outcome was all-cause mortality, with secondary outcomes including all major complications. Five studies (n=274 patients) and eight case reports were included. Device success was reported in 94.9% of the patients, the all-cause mortality rate was 4.4%, 2.5% were converted to SAVR, 1.7% had post-operative paravalvular leak and 6.7% required permanent pacemaker implantation. CONCLUSIONS: TAVR has demonstrated acceptable safety and efficacy in Asian patients with pure AR displaying low mortality rates and few adverse outcomes.
AIMS: Although surgical aortic valve replacement (SAVR) is currently the recommended intervention for patients with native AR without aortic stenosis, a significant proportion of Asian patients undergo transcatheter aortic valve replacement (TAVR), which has not been studied fully for safety and outcomes. This systematic review aims to examine the characteristics and outcomes of Asian patients with pure native aortic regurgitation (AR) undergoing TAVR. METHODS AND RESULTS: PubMed, Embase, Scopus, Web of Science and Cochrane CENTRAL were systematically searched for randomised controlled trials, observational studies and case reports published from inception to 2 April 2020, involving patients of Asian ethnicity with pure native aortic regurgitation who had undergone TAVR. Our primary outcome was all-cause mortality, with secondary outcomes including all major complications. Five studies (n=274 patients) and eight case reports were included. Device success was reported in 94.9% of the patients, the all-cause mortality rate was 4.4%, 2.5% were converted to SAVR, 1.7% had post-operative paravalvular leak and 6.7% required permanent pacemaker implantation. CONCLUSIONS: TAVR has demonstrated acceptable safety and efficacy in Asian patients with pure AR displaying low mortality rates and few adverse outcomes.
Authors: Martin B Leon; Craig R Smith; Michael Mack; D Craig Miller; Jeffrey W Moses; Lars G Svensson; E Murat Tuzcu; John G Webb; Gregory P Fontana; Raj R Makkar; David L Brown; Peter C Block; Robert A Guyton; Augusto D Pichard; Joseph E Bavaria; Howard C Herrmann; Pamela S Douglas; John L Petersen; Jodi J Akin; William N Anderson; Duolao Wang; Stuart Pocock Journal: N Engl J Med Date: 2010-09-22 Impact factor: 91.245
Authors: Henrique B Ribeiro; John G Webb; Raj R Makkar; Mauricio G Cohen; Samir R Kapadia; Susheel Kodali; Corrado Tamburino; Marco Barbanti; Tarun Chakravarty; Hasan Jilaihawi; Jean-Michel Paradis; Fabio S de Brito; Sergio J Cánovas; Asim N Cheema; Peter P de Jaegere; Raquel del Valle; Paul T L Chiam; Raúl Moreno; Gonzalo Pradas; Marc Ruel; Jorge Salgado-Fernández; Rogerio Sarmento-Leite; Hadi D Toeg; James L Velianou; Alan Zajarias; Vasilis Babaliaros; Fernando Cura; Antonio E Dager; Ganesh Manoharan; Stamatios Lerakis; Augusto D Pichard; Sam Radhakrishnan; Marco Antonio Perin; Eric Dumont; Eric Larose; Sergio G Pasian; Luis Nombela-Franco; Marina Urena; E Murat Tuzcu; Martin B Leon; Ignacio J Amat-Santos; Jonathon Leipsic; Josep Rodés-Cabau Journal: J Am Coll Cardiol Date: 2013-08-14 Impact factor: 24.094
Authors: Samir R Kapadia; E Murat Tuzcu; Raj R Makkar; Lars G Svensson; Shikhar Agarwal; Susheel Kodali; Gregory P Fontana; John G Webb; Michael Mack; Vinod H Thourani; Vasilis C Babaliaros; Howard C Herrmann; Wilson Szeto; Augusto D Pichard; Mathew R Williams; William N Anderson; Jodi J Akin; D Craig Miller; Craig R Smith; Martin B Leon Journal: Circulation Date: 2014-09-09 Impact factor: 29.690