Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Inhibition of human liver cytochrome P-450 by omeprazole.

Literature DB >> 3485990

Inhibition of human liver cytochrome P-450 by omeprazole.

Abstract

The effects of omeprazole on cytochrome P-450 mediated 7-ethoxycoumarin deethylation were studied in human liver microsomes. Omeprazole inhibited both the high and low affinity components of deethylation, with an estimated Ki of 0.03 mM for the high affinity component. The results are further evidence that the previously reported prolongation of the half-life of diazepam by omeprazole in vivo is due to inhibition of cytochrome P-450 monooxygenases.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 1986 PMID： 3485990 PMCID： PMC1400857 DOI： 10.1111/j.1365-2125.1986.tb05199.x

Source DB: PubMed Journal: Br J Clin Pharmacol ISSN： 0306-5251 Impact factor: 4.335

13 in total

1. THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE.

Authors: T OMURA; R SATO
Journal: J Biol Chem Date: 1964-07 Impact factor: 5.157

2. Drug metabolism in human liver in vitro: establishment of a human liver bank.

Authors: C von Bahr; C G Groth; H Jansson; G Lundgren; M Lind; H Glaumann
Journal: Clin Pharmacol Ther Date: 1980-06 Impact factor: 6.875

3. Delayed clearance of diazepam due to cimetidine.

Authors: U Klotz; I Reimann
Journal: N Engl J Med Date: 1980-05-01 Impact factor: 91.245

4. An improved assay of 7-ethoxycoumarin O-deethylase activity: induction of hepatic enzyme activity in C57BL/6J and DBA/2J mice by phenobarbital, 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Authors: W F Greenlee; A Poland
Journal: J Pharmacol Exp Ther Date: 1978-06 Impact factor: 4.030

5. Omeprazole in Zollinger-Ellison syndrome. Effects of a single dose and of long-term treatment in patients resistant to histamine H2-receptor antagonists.

Authors: C B Lambers; T Lind; S Moberg; J B Jansen; L Olbe
Journal: N Engl J Med Date: 1984-03-22 Impact factor: 91.245

6. Simultaneous high-performance liquid chromatographic analysis of omeprazole and its sulphone and sulphide metabolites in human plasma and urine.

Authors: G W Mihaly; P J Prichard; R A Smallwood; N D Yeomans; W J Louis
Journal: J Chromatogr Date: 1983-12-09

7. Inhibition of gastric acid secretion by omeprazole in the dog and rat.

Authors: H Larsson; E Carlsson; U Junggren; L Olbe; S E Sjöstrand; I Skånberg; G Sundell
Journal: Gastroenterology Date: 1983-10 Impact factor: 22.682

8. The effect of alcoholic cirrhosis on the two kinetic components (high and low affinity) of the microsomal 0-deethylation of 7-ethoxycoumarin in human liver.

Authors: K W Woodhouse; F M Williams; E Mutch; P Wright; O F James; M D Rawlins
Journal: Eur J Clin Pharmacol Date: 1984 Impact factor: 2.953

9. Elevation of steady-state diazepam levels by cimetidine.

Authors: U Klotz; I Reimann
Journal: Clin Pharmacol Ther Date: 1981-10 Impact factor: 6.875

10. Effect of omeprazole--a gastric proton pump inhibitor--on pentagastrin stimulated acid secretion in man.

Authors: T Lind; C Cederberg; G Ekenved; U Haglund; L Olbe
Journal: Gut Date: 1983-04 Impact factor: 23.059

14 in total

1. Endocrine adverse effects of omeprazole.

Authors: M Lindquist; I R Edwards
Journal: BMJ Date: 1992-08-22

Review 2. Clinical pharmacokinetics of drugs used in the treatment of gastrointestinal diseases (Part II).

Authors: K Lauritsen; L S Laursen; J Rask-Madsen
Journal: Clin Pharmacokinet Date: 1990-08 Impact factor: 6.447

3. Effect of single and repeated intravenous doses of omeprazole on pentagastrin stimulated gastric acid secretion and pharmacokinetics in man.

Authors: J B Jansen; P Lundborg; L C Baak; J Greve; M Ohman; C Stöver; K Röhss; C B Lamers
Journal: Gut Date: 1988-01 Impact factor: 23.059

4. Interaction study of lomefloxacin and ciprofloxacin with omeprazole and comparative pharmacokinetics.

Authors: H Stuht; H Lode; P Koeppe; K L Rost; T Schaberg
Journal: Antimicrob Agents Chemother Date: 1995-05 Impact factor: 5.191

5. Intravenous proton pump inhibitors for peptic ulcer bleeding: Clinical benefits and limits.

Authors: Hsiu-Chi Cheng; Bor-Shyang Sheu
Journal: World J Gastrointest Endosc Date: 2011-03-16

6. Human liver microsomal metabolism of the enantiomers of warfarin and acenocoumarol: P450 isozyme diversity determines the differences in their pharmacokinetics.

Authors: J J Hermans; H H Thijssen
Journal: Br J Pharmacol Date: 1993-09 Impact factor: 8.739