Anni Lepola1,2, Otso Arponen3,4, Hidemi Okuma1,2, Kirsi Holli-Helenius4,5, Heikki Junkkari6,7, Mervi Könönen2, Päivi Auvinen8,9, Mazen Sudah1,2, Anna Sutela1,2, Ritva Vanninen1,2. 1. Institute of Clinical Medicine, School of Medicine, Clinical Radiology, University of Eastern Finland, Kuopio, Finland. 2. Department of Clinical Radiology, Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland. 3. Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. 4. Department of Radiology, Tampere University Hospital, Tampere, Finland. 5. Department of Medical Physics, Tampere University Hospital, Tampere, Finland. 6. Department of Oncology, Comprehensive Cancer Center, Helsinki University Hospital, Helsinki, Finland. 7. Faculty of Medicine, University of Helsinki, Helsinki, Finland. 8. Institute of Clinical Medicine, School of Medicine, Oncology, University of Eastern Finland, Kuopio, Finland. 9. Department of Oncology, Cancer Center, Kuopio University Hospital, Kuopio, Finland.
Abstract
OBJECTIVES: The aim of this exploratory study was to evaluate whether three-dimensional texture analysis (3D-TA) features of non-contrast-enhanced T1 weighted MRI associate with traditional prognostic factors and disease-free survival (DFS) of breast cancer. METHODS: 3D-T1 weighted images from 78 patients with 81 malignant histopathologically verified breast lesions were retrospectively analysed using standard-size volumes of interest. Grey-level co-occurrence matrix (GLCM)-based features were selected for statistical analysis. In statistics the Mann-Whitney U and the Kruskal-Wallis tests, the Cox proportional hazards model and the Kaplan-Meier method were used. RESULTS: Tumours with higher histological grade were significantly associated with higher contrast (1 voxel: p = 0.033, 2 voxels: p = 0.036). All the entropy parameters showed significant correlation with tumour grade (p = 0.015-0.050) but there were no statistically significant associations between other TA parameters and tumour grade. The Nottingham Prognostic Index (NPI) was correlated with contrast and sum entropy parameters. A higher sum variance TA parameter was a significant predictor of shorter DFS. CONCLUSION: Texture parameters, assessed by 3D-TA from non-enhanced T1 weighted images, indicate tumour heterogeneity but have limited independent prognostic value. However, they are associated with tumour grade, NPI, and DFS. These parameters could be used as an adjunct to contrast-enhanced TA parameters. ADVANCES IN KNOWLEDGE: 3D-TA of non-contrast enhanced T1 weighted breast MRI associates with tumour grade, NPI, and DFS. The use of non-contrast 3D-TA parameters in adjunct with contrast-enhanced 3D-TA parameters warrants further research.
OBJECTIVES: The aim of this exploratory study was to evaluate whether three-dimensional texture analysis (3D-TA) features of non-contrast-enhanced T1 weighted MRI associate with traditional prognostic factors and disease-free survival (DFS) of breast cancer. METHODS: 3D-T1 weighted images from 78 patients with 81 malignant histopathologically verified breast lesions were retrospectively analysed using standard-size volumes of interest. Grey-level co-occurrence matrix (GLCM)-based features were selected for statistical analysis. In statistics the Mann-Whitney U and the Kruskal-Wallis tests, the Cox proportional hazards model and the Kaplan-Meier method were used. RESULTS: Tumours with higher histological grade were significantly associated with higher contrast (1 voxel: p = 0.033, 2 voxels: p = 0.036). All the entropy parameters showed significant correlation with tumour grade (p = 0.015-0.050) but there were no statistically significant associations between other TA parameters and tumour grade. The Nottingham Prognostic Index (NPI) was correlated with contrast and sum entropy parameters. A higher sum variance TA parameter was a significant predictor of shorter DFS. CONCLUSION: Texture parameters, assessed by 3D-TA from non-enhanced T1 weighted images, indicate tumour heterogeneity but have limited independent prognostic value. However, they are associated with tumour grade, NPI, and DFS. These parameters could be used as an adjunct to contrast-enhanced TA parameters. ADVANCES IN KNOWLEDGE: 3D-TA of non-contrast enhanced T1 weighted breast MRI associates with tumour grade, NPI, and DFS. The use of non-contrast 3D-TA parameters in adjunct with contrast-enhanced 3D-TA parameters warrants further research.
Authors: Mahesh B Nagarajan; Markus B Huber; Thomas Schlossbauer; Gerda Leinsinger; Andrzej Krol; Axel Wismüller Journal: J Med Biol Eng Date: 2013-01-01 Impact factor: 1.553
Authors: Ján Remšík; Radek Fedr; Jiří Navrátil; Lucia Binó; Eva Slabáková; Pavel Fabian; Marek Svoboda; Karel Souček Journal: Br J Cancer Date: 2018-02-20 Impact factor: 7.640