Hesperidin Preserves Cognitive Functions and Hippocampus Histological Architecture in Albino Wistar Rats Subjected to Stress Through Enhancement of Brain-Derived Neurotrophic Factor.

Hesperidin (HSD) is a natural compound with antioxidant potential. On the other hand, chronic stress had been linked to impaired cognitive functions as it affects many neurotransmitters and brain regions such as the hippocampus. The current study was conducted to examine the effect of HSD on learning and memory after chronic mild stress. Albino Wistar rats were subjected to chronic mild stress with HSD administered as supplements. HSD was found to decrease hippocampal amyloid beta and malondialdehyde levels, in addition, to preserve cognitive functions together with preserving hippocampus histological architecture. In conclusion, the present study sheds the light on the potential of HSD to ameliorate the deleterious effects of chronic mild stress on cognitive functions through brain-derived neurotrophic factor enhancement and reduction in Aβ formation in addition to activation of the antioxidant pathway.