| Literature DB >> 30825464 |
Maofang Hei1, Peng Chen2, Shuzhong Wang1, Xuzhao Li1, Mingrui Xu1, Xiaoyan Zhu1, Yi Wang3, Jinyou Duan2, Yong Huang4, Shanting Zhao5.
Abstract
Chronic mild stress (CMS) model is most similar to the depression human suffered in daily life. Strong evidence proved the important role of hippocampal synaptic plasticity in the mechanism of depression. This study investigated the effect of CMS on synaptic plasticity in hippocampus. Our results showed that CMS impaired spatial memory and exploring ability, disturbed the release of neurotransmitters including 5-hydroxytryptamine (5-HT) and dopamine (DA), reduced the density of synaptic vesicle in inner molecular layer, increased the number of thin spines in inner and outer molecular layer, whereas did not affect the density of spine apparatus, the above mentioned were probably related to the reduction of astrocytes and activation of microglial cells.Entities:
Keywords: Chronic mild stress; Molecular layer; Spine; Synapse; Synaptic plasticity
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Year: 2019 PMID： 30825464 DOI： 10.1016/j.bbr.2019.02.044
Source DB: PubMed Journal: Behav Brain Res ISSN： 0166-4328 Impact factor: 3.332